Search Results - "BDEIR, K"

Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination by Choi, E Y, Lim, J-H, Neuwirth, A, Economopoulou, M, Chatzigeorgiou, A, Chung, K-J, Bittner, S, Lee, S-H, Langer, H, Samus, M, Kim, H, Cho, G-S, Ziemssen, T, Bdeir, K, Chavakis, E, Koh, J-Y, Boon, L, Hosur, K, Bornstein, S R, Meuth, S G, Hajishengallis, G, Chavakis, T

“…Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS)…”
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Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore) by Pixley, R A, Espinola, R G, Ghebrehiwet, B, Joseph, K, Kao, A, Bdeir, K, Cines, D B, Colman, R W

“…The physiologic activation of the plasma kallikrein-kinin system requires the assembly of its constituents on a cell membrane. High- molecular-weight kininogen…”
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Urokinase mediates fibrinolysis in the pulmonary microvasculature by Bdeir, Khalil, Murciano, Juan-Carlos, Tomaszewski, John, Koniaris, Lauren, Martinez, Jose, Cines, Douglas B., Muzykantov, Vladimir R., Higazi, Abd Al-Roof

“…The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in fibrinolysis remains unsettled. The contribution of uPA may depend on the…”
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A Region in Domain II of the Urokinase Receptor Required for Urokinase Binding by Bdeir, K, Kuo, A, Mazar, A, Sachais, B S, Xiao, W, Gawlak, S, Harris, S, Higazi, A A, Cines, D B

“…The urokinase receptor is composed of three homologous domains based on disulfide spacing. The contribution of each domain to the binding and activation of…”
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Binding of urokinase plasminogen activator to gp130 via a putative urokinase-binding consensus sequence by Liang, Olin D, Chavakis, Triantafyllos, Linder, Monica, Bdeir, Khalil, Kuo, Alice, Preissner, Klaus T

“…Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are instrumental in cellular activities during inflammation, angiogenesis and tumor…”
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The α-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis by Higazi, Abd Al-Roof, Nassar, Taher, Ganz, Tomas, Rader, Daniel J., Udassin, Raphael, Bdeir, Khalil, Hiss, Edna, Sachais, Bruce S., Williams, Kevin Jon, Leitersdorf, Eran, Cines, Douglas B.

“…Inflammation may contribute to the pathogenesis of atherosclerosis. On the basis of previous reports that human atherosclerotic lesions contain α-defensins, a…”
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uPA Contributes To Initial Age Dependent Cerebrovascular Hyperemia After Brain Injury Through LRP and ERK MAPK by Armstead, WM, Cines, DB, Bdeir, K, Stein, SC, Higazi, AAR

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Novel Interactions between Urokinase and Its Receptor by Shliom, Ori, Huang, Mingdong, Sachais, Bruce, Kuo, Alice, Weisel, John W., Nagaswami, Chandrasekaran, Nassar, Taher, Bdeir, Khalil, Hiss, Edna, Gawlak, Susan, Harris, Scott, Mazar, Andrew, Higazi, Abd Al-Roof

“…Urokinase-type plasminogen activator (uPA) binds to its receptor (uPAR) with a Kd of about 1 nm. The catalytic activity of the complex is apparent at uPA…”
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The Structure of Lipoprotein(a) and Ligand-Induced Conformational Changes by Weisel, John W, Nagaswami, Chandrasekaran, Woodhead, John L, Higazi, Abd Al-Roof, Cain, William J, Marcovina, Santica M, Koschinsky, Marlys L, Cines, Douglas B, Bdeir, Khalil

“…Lipoprotein(a) is composed of low-density lipoprotein linked both covalently and noncovalently to apolipoprotein(a). The structure of lipoprotein(a) and the…”
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ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model by Ostertag, Eric M., Bdeir, Khalil, Kacir, Stephen, Thiboutot, Michelle, Gulendran, Gayathri, Yunk, Lenka, Hayes, Vincent M., Motto, David G., Poncz, Mortimer, Zheng, X. Long, Cines, Douglas B., Siegel, Don L.

“…BACKGROUND Acquired thrombotic thrombocytopenic purpura (TTP) is a potentially fatal disease in which ultralarge von Willebrand factor (UL‐VWF) multimers…”
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B96 HIGHLIGHTS IN PULMONARY REHABILITATION: 2013: Outcomes Evaluation Of A Maintenance 3-Year Follow-Up Pulmonary Rehabilitation Program by Cejudo, P, Galdiz, B, Puy, C, Indart, L Martinez, Ortega, F, Vazquez-Sanchez, R, Trigo, G Rodriguez, Bdeir, K, Morante, F, Santamaria, E Lopez, Regueiro, M, Guell, R

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Inhibition of ADAMTS13 Activity By Human Neutrophil Peptide 1 (HNP-1): Potential Link Between Inflammation, Onset of Thrombotic Thrombocytopenic Purpura, and Other Thrombosis by Bao, Jialing, Bdeir, Khalil, Siegel, Don L., Cines, Douglas B., Zheng, X. Long

“…Thrombotic thrombocytopenic purpura (TTP) is a potentially fatal syndrome associated with severe deficiency of plasma ADAMTS13 activity resulting from either…”
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Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-κB–dependent manner by Yu, Guangyao, Rux, Ann H., Ma, Peihong, Bdeir, Khalil, Sachais, Bruce S.

“…The involvement of platelets in the pathogenesis of atherosclerosis has recently gained much attention. Platelet factor 4 (PF4), a platelet-specific chemokine…”
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Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac‐1 integrin by Sotiriou, Sotirios N., Orlova, Valeria V., Al‐Fakhri, Nadia, Ihanus, Eveliina, Economopoulou, Matina, Isermann, Berend, Bdeir, Khalil, Nawroth, Peter P., Preissner, Klaus T., Gahmberg, Carl G., Koschinsky, Marlys L., Chavakis, Triantafyllos

“…Lipoprotein(a) [Lp(a)], consisting of LDL and the unique constituent apolipoprotein(a) [apo(a)], which contains multiple repeats resembling plasminogen kringle…”
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Regulation of neovascularization by human neutrophil peptides (α‐defensins): a link between inflammation and angiogenesis by Chavakis, Triantafyllos, Cines, Douglas B., Rhee, Joong-Sup, Liang, Olin D., Schubert, Uwe, Hammes, Hans-Peter, Higazi, Abd Al-Roof, Nawroth, Peter P., Preissner, Klaus T., Bdeir, Khalil

“…ABSTRACT Angiogenesis, the growth of new blood vessels, is a complex biological process that is orchestrated by several growth factors and components of the…”
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Inhibition of pathologic retinal neovascularization by α-defensins by Economopoulou, Matina, Bdeir, Khalil, Cines, Douglas B., Fogt, Franz, Bdeir, Yasmina, Lubkowski, Jacek, Lu, Wuyuan, Preissner, Klaus T., Hammes, Hans-Peter, Chavakis, Triantafyllos

“…Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is…”
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In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone by Nassar, Taher, Akkawi, Sa’ed, Shina, Ahuva, Haj-Yehia, Abdullah, Bdeir, Khalil, Tarshis, Mark, Heyman, Samuel N., Higazi, Abd Al-Roof

“…Tissue type plasminogen activator (tPA) is a key enzyme in the fibrinolytic cascade. In this paper we report that tPA contains 2 independent epitopes that…”
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Blood clearance and activity of erythrocyte-coupled fibrinolytics by Ganguly, Kumkum, Krasik, Tatiana, Medinilla, Sandra, Bdeir, Khalil, Cines, Douglas B, Muzykantov, Vladimir R, Murciano, Juan Carlos

“…Conjugating tissue-type plasminogen activator (tPA) to red blood cells (RBCs) endows it with features useful for thromboprophylaxis. However, the optimal…”
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Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation by Tarui, Takehiko, Akakura, Nobuaki, Majumdar, Mousumi, Andronicos, Nicholas, Takagi, Junichi, Mazar, Andrew P, Bdeir, Khalil, Kuo, Alice, Yarovoi, Serge V, Cines, Douglas B, Takada, Yoshikazu

“…It has been questioned whether there are receptors for urokinase-type plasminogen activator (uPA) that facilitate plasminogen activation other than the high…”
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Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance by Paulin, Nicole, Döring, Yvonne, Kooijman, Sander, Blanchet, Xavier, Viola, Joana R., de Jong, Renske, Mandl, Manuela, Hendrikse, Jeffrey, Schiener, Maximilian, von Hundelshausen, Philipp, Vogt, Anja, Weber, Christian, Bdeir, Khalil, Hofmann, Susanna M., Rensen, Patrick C.N., Drechsler, Maik, Soehnlein, Oliver

“…Increases in plasma LDL-cholesterol have unequivocally been established as a causal risk factor for atherosclerosis. Hence, strategies for lowering of…”
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