Search Results - "BAZZANI, Carla"
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Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats
Published in Critical care medicine (01-11-2005)“…OBJECTIVE:A vagus nerve–mediated, brain cholinergic protective mechanism activated by melanocortin peptides is operative in conditions of circulatory shock;…”
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Protective effect of melanocortin peptides in rat myocardial ischemia
Published in The Journal of pharmacology and experimental therapeutics (01-06-2001)“…The influence of the melanocortin peptide ACTH-(1-24) (adrenocorticotropin) on the consequences of short-term coronary ischemia (5 min) followed by…”
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Evidence that melanocortin 4 receptor mediates hemorrhagic shock reversal caused by melanocortin peptides
Published in The Journal of pharmacology and experimental therapeutics (01-12-1999)“…Melanocortin peptides are known to be extremely potent in causing the sustained reversal of different shock conditions, both in experimental animals and…”
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Adrenocorticotropin reverses vascular dysfunction and protects against splanchnic artery occlusion shock
Published in British journal of pharmacology (01-10-1999)“…Tumour necrosis factor (TNF‐α) is involved in the pathogenesis of splanchnic artery occlusion (SAO) shock. On the other hand, inhibition of TNF‐α is an…”
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Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway
Published in Cardiovascular research (01-08-2004)“…Several melanocortin peptides have a prompt and sustained resuscitating effect in conditions of hemorrhagic shock. The transcription nuclear factor kappaB…”
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Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins
Published in European journal of pharmacology (10-09-2007)“…In gerbils subjected to transient global cerebral ischemia, melanocortin peptides produce long-lasting protection with a broad time window, and through the…”
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Both Early and Delayed Treatment with Melanocortin 4 Receptor-Stimulating Melanocortins Produces Neuroprotection in Cerebral Ischemia
Published in Endocrinology (Philadelphia) (01-03-2006)“…Ischemic stroke is one of the main causes of death and disability. We investigated whether melanocortin peptides, which have protective effects in severe…”
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Broad therapeutic treatment window of [Nle 4, D-Phe 7]α-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils
Published in European journal of pharmacology (24-05-2006)“…Melanocortin peptides have been shown to produce neuroprotection in experimental ischemic stroke. The aim of the present investigation was to identify the…”
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Melanocortins and the cholinergic anti-inflammatory pathway
Published in Advances in experimental medicine and biology (2010)“…Experimental evidence indicates that small concentrations of inflammatory molecules produced by damaged tissues activate afferent signals through ascending…”
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Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors
Published in European journal of pharmacology (23-09-2003)“…In rats subjected to myocardial ischemia/reperfusion, melanocortin peptides, including gamma(1)-melanocyte-stimulating hormone (gamma(1)-MSH), are able to…”
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Oxidative stress causes nuclear factor-κB activation in acute hypovolemic hemorrhagic shock
Published in Free radical biology & medicine (15-05-2001)“…Nuclear Factor κB (NFκB) is an ubiquitous rapid response transcription factor involved in inflammatory reactions and exerts its action by expressing cytokines,…”
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Involvement of the central nervous system in the protective effect of melanocortins in myocardial ischaemia/reperfusion injury
Published in Resuscitation (2002)“…Melanocortin peptides exert, in rats, a protective effect in myocardial ischaemia followed by reperfusion, or permanent occlusion of a coronary artery…”
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Resuscitating effect of melanocortin peptides after prolonged respiratory arrest
Published in British journal of pharmacology (01-08-1997)“…The resuscitating activity of melanocortin peptides (MSH‐ACTH peptides) was tested in an experimental model of prolonged respiratory arrest. Anaesthetized,…”
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Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock
Published in Shock (Augusta, Ga.) (01-05-2006)“…The cholinergic anti-inflammatory pathway has not yet been studied in splanchnic artery occlusion (SAO) shock. We investigated whether electrical stimulation…”
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Evidence for a role of nuclear factor-κB in acute hypovolemic hemorrhagic shock
Published in Surgery (01-01-2002)“…Background. In acute hypovolemic shock, a rapid systemic release of the inflammatory cytokine tumor necrosis factor (TNF-α) contributes to vascular failure…”
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Cannabinoid CB1 receptor blockade enhances the protective effect of melanocortins in hemorrhagic shock in the rat
Published in European journal of pharmacology (19-04-2002)Get full text
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Cannabinoid CB(1) receptor blockade enhances the protective effect of melanocortins in hemorrhagic shock in the rat
Published in European journal of pharmacology (19-04-2002)“…Activation of peripheral cannabinoid CB(1) receptors contributes to hemorrhagic hypotension, and endocannabinoids produced by macrophages and platelets may be…”
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