Search Results - "BAYNES, John W"

Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications by NAGAI, Ryoji, MURRAY, David B, METZ, Thomas O, BAYNES, John W

“…This article outlines evidence that advanced glycation end product (AGE) inhibitors and breakers act primarily as chelators, inhibiting metal-catalyzed…”
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A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease by Zhang, Qibin, Ames, Jennifer M, Smith, Richard D, Baynes, John W, Metz, Thomas O

“…The Maillard reaction, starting from the glycation of protein and progressing to the formation of advanced glycation end-products (AGEs), is implicated in the…”
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The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse by White, James P, Baynes, John W, Welle, Stephen L, Kostek, Matthew C, Matesic, Lydia E, Sato, Shuichi, Carson, James A

“…Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+) mouse is a…”
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The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse by White, James P., Baynes, John W., Welle, Stephen L., Kostek, Matthew C., Matesic, Lydia E., Sato, Shuichi, Carson, James A.

“…Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The ApcMin/+ mouse is a…”
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Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity by Frizzell, Norma, Thomas, Sonia A, Carson, James A, Baynes, John W

“…2SC [S-(2-succino)-cysteine] is a chemical modification formed by a Michael addition reaction of fumarate with cysteine residues in proteins. Formation of 2SC,…”
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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status by Bardella, Chiara, El-Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth, Taylor, Jennifer, Giaslakiotis, Konstantinos, Macaulay, Valentine M, Harris, Adrian L, Chandra, Ashish, Lehtonen, Heli J, Launonen, Virpi, Aaltonen, Lauri A, Pugh, Christopher W, Mihai, Radu, Trudgian, David, Kessler, Benedikt, Baynes, John W, Ratcliffe, Peter J, Tomlinson, Ian P, Pollard, Patrick J

“…Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC)…”
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Muscle oxidative capacity during IL-6-dependent cancer cachexia by White, James P, Baltgalvis, Kristen A, Puppa, Melissa J, Sato, Shuichi, Baynes, John W, Carson, James A

“…Many diseases are associated with catabolic conditions that induce skeletal muscle wasting. These various catabolic states may have similar and distinct…”
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IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse by White, James P, Puppa, Melissa J, Sato, Shuichi, Gao, Song, Price, Robert L, Baynes, John W, Kostek, Matthew C, Matesic, Lydia E, Carson, James A

“…Muscle protein turnover regulation during cancer cachexia is being rapidly defined, and skeletal muscle mitochondria function appears coupled to processes…”
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Skin Autofluorescence Is a Strong Predictor of Cardiac Mortality in Diabetes by Meerwaldt, Robbert, Lutgers, Helen L, Links, Thera P, Graaff, Reindert, Baynes, John W, Gans, Rijk O.B, Smit, Andries J

“…OBJECTIVE:--Advanced glycation end products (AGEs) are biomarkers of metabolic stress and are thought to contribute to the increase of coronary heart disease…”
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The succinated proteome by Merkley, Eric D., Metz, Thomas O., Smith, Richard D., Baynes, John W., Frizzell, Norma

“…The post‐translational modifications (PTMs) of cysteine residues include oxidation, S‐glutathionylation, S‐nitrosylation, and succination, all of which modify…”
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Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats by Nagai, Ryoji, Nagai, Mime, Shimasaki, Satoko, Baynes, John W., Fujiwara, Yukio

“…Although many fruits such as lemon and orange contain citric acid, little is known about beneficial effects of citric acid on health. Here we measured the…”
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Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients by MEERWALDT, Robbert, HARTOG, Jasper W. L, SMIT, Andries J, GRAAFF, Reindert, HUISMAN, Roel J, LINKS, Thera P, DEN HOLLANDER, Nynke C, THORPE, Susan R, BAYNES, John W, NAVIS, Gerjan, GANS, Rijk O. B

“…Tissue advanced glycation end products (AGE) are a measure of cumulative metabolic stress and trigger cytokines driven inflammatory reactions. AGE are thought…”
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Glycoxidation and lipoxidation in atherogenesis by Baynes, John W, Thorpe, Suzanne R

“…Atherosclerosis may be viewed as an age-related disease initiated by nonenzymatic, chemical reactions in a biological system. The peroxidation of lipids in…”
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The Maillard Hypothesis on Aging: Time to Focus on DNA by BAYNES, JOHN W.

“…Aging is the outcome of the contest between chemistry and biology in living systems. Chronic, cumulative chemical modifications compromise the structure and…”
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Simple Noninvasive Measurement of Skin Autofluorescence by MEERWALDT, ROBBERT, LINKS, THERA, GRAAFF, REINDERT, THORPE, SUZANNNE R., BAYNES, JOHN W., HARTOG, JASPER, GANS, REINOLD, SMIT, ANDRIES

“…: Accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus and renal…”
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The anti-cancer drug, doxorubicin, causes oxidant stress-induced endothelial dysfunction by Wolf, Matthew B., Baynes, John W.

“…The anticancer drug doxorubicin (DOX) is toxic to target cells, but also causes endothelial dysfunction and edema, secondary to oxidative stress in the…”
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The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes by STITT, Alan, GARDINER, Thomas A, THORPE, Suzanne R, ANDERSON, Nathan L, CANNING, Paul, FRIZZELL, Norma, DUFFY, Noel, BOYLE, Cliona, JANUSZEWSKI, Andrzej S, CHACHICH, Mark, BAYNES, John W

“…The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes Alan Stitt 1 , Thomas A. Gardiner 1 , Nathan L. Anderson 2 , Paul…”
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Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat by Degenhardt, Thorsten P., Alderson, Nathan L., Arrington, David D., Beattie, Robert J., Basgen, John M., Steffes, Michael W., Thorpe, Suzanne R., Baynes, John W.

“…Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat. Nonenzymatic reactions between sugars or lipids and protein and…”
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Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications by Metz, Thomas O, Alderson, Nathan L, Thorpe, Suzanne R, Baynes, John W

“…Pyridoxamine (PM), originally described as a post-Amadori inhibitor of formation of advanced glycation end-products (AGEs), also inhibits the formation of…”
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Improved Methods for the Enrichment and Analysis of Glycated Peptides by Zhang, Qibin, Schepmoes, Athena A, Brock, Jonathan W. C, Wu, Si, Moore, Ronald J, Purvine, Samuel O, Baynes, John W, Smith, Richard D, Metz, Thomas O

“…Nonenzymatic glycation of tissue proteins has important implications in the development of complications of diabetes mellitus. Herein we report improved…”
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