Search Results - "BAYLIN, S. B"

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer by Suzuki, H, Toyota, M, Caraway, H, Gabrielson, E, Ohmura, T, Fujikane, T, Nishikawa, N, Sogabe, Y, Nojima, M, Sonoda, T, Mori, M, Hirata, K, Imai, K, Shinomura, Y, Baylin, S B, Tokino, T

“…Although mutation of APC or CTNNB1 ( β -catenin) is rare in breast cancer, activation of Wnt signalling is nonetheless thought to play an important role in…”
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Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer by Baylin, S B, Esteller, M, Rountree, M R, Bachman, K E, Schuebel, K, Herman, J G

“…Gene function in cancer can be disrupted either through genetic alterations, which directly mutate or delete genes, or epigenetic alterations, which alter the…”
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The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes by Cai, Y, Geutjes, E-J, de Lint, K, Roepman, P, Bruurs, L, Yu, L-R, Wang, W, van Blijswijk, J, Mohammad, H, de Rink, I, Bernards, R, Baylin, S B

“…Many tumor suppressor genes (TSGs) are silenced through synergistic layers of epigenetic regulation including abnormal DNA hypermethylation of promoter CpG…”
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Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas by WEN, X.-Z, AKIYAMA, Y, BAYLIN, S. B, YUASA, Y

“…Recently, it was reported that exogenous bone morphogenetic protein (BMP)-2 acted as an antiproliferative agent in a variety of cell lines, including normal…”
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DNA hypermethylation in tumorigenesis: epigenetics joins genetics by Baylin, Stephen B, Herman, James G

“…Recently, the concept that epigenetic, as well as genetic, events might be central to the evolution of human cancer is re-emerging. Cancers often exhibit an…”
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Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1 c-Myc by Licchesi, J D F, Van Neste, L, Tiwari, V K, Cope, L, Lin, X, Baylin, S B, Herman, J G

“…The Wnt signaling pathway is capable of self-regulation through positive and negative feedback mechanisms. For example, the oncoprotein c-Myc, which is…”
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DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci by Rountree, Michael R, Bachman, Kurtis E, Baylin, Stephen B

“…DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain…”
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Predicting lung cancer by detecting aberrant promoter methylation in sputum by PALMISANO, William A, DIVINE, Kevin K, SACCOMANNO, Geno, GILLILAND, Frank D, BAYLIN, Stephen B, HERMAN, James G, BELINSKY, Steven A

“…Despite the promise of using DNA markers for the early detection of cancer, none has proven universally applicable to the most common and lethal forms of human…”
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Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors by Esteller, Manel, Silva, Jose Maria, Dominguez, Gemma, Bonilla, Felix, Matias-Guiu, Xavier, Lerma, Enrique, Bussaglia, Elena, Prat, Jaime, Harkes, I. Clara, Repasky, Elizabeth A., Gabrielson, Edward, Schutte, Mieke, Baylin, Stephen B., Herman, James G.

“…Background: Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However, somatic (acquired) mutations in…”
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Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients by ESTELLER, M, SANCHEZ-CESPEDES, M, ROSELL, R, SIDRANSKY, D, BAYLIN, S. B, HERMAN, J. G

“…Recent evidence suggests that tumor cells may release DNA into the circulation, which is enriched in the serum and plasma, allowing detection of ras and p53…”
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Aberrant Methylation of Gene Promoters in Cancer—Concepts, Misconcepts, and Promise by Baylin, Stephen B., Belinsky, Steven A., Herman, James G.

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DNA methylation, chromatin inheritance, and cancer by Rountree, M R, Bachman, K E, Herman, J G, Baylin, S B

“…Cancer is a process driven by the accumulation of abnormalities in gene function. While many of these changes are genetic, epigenetically mediated changes in…”
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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer by Baylin, Stephen B, Cameron, Elizabeth E, Bachman, Kurtis E, Myöhänen, Sanna, Herman, James G

“…Densely methylated DNA associates with transcriptionally repressive chromatin characterized by the presence of underacetylated histones. Recently, these two…”
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Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype by TOYOTA, M, AHUJA, N, SUZUKI, H, ITOH, F, OHE-TOYOTA, M, IMAI, K, BAYLIN, S. B, ISSA, J.-P. J

“…Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a…”
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Promoter-region hypermethylation and gene silencing in human cancer by Herman, J G, Baylin, S B

“…In summary, it is apparent that alterations in DNA methylation are a fundamental molecular change associated with the neoplastic process and have important…”
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A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1 by Zhang, W, Zeng, X, Briggs, K J, Beaty, R, Simons, B, Chiu Yen, R-W, Tyler, M A, Tsai, H-C, Ye, Y, Gesell, G S, Herman, J G, Baylin, S B, Watkins, D N

“…The tumor suppressor gene hypermethylated in cancer 1 ( HIC1 ), which encodes a transcriptional repressor, is epigenetically inactivated in various human…”
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Loss of a single Hic1 allele accelerates polyp formation in ApcΔ716 mice by Mohammad, H P, Zhang, W, Prevas, H S, Leadem, B R, Zhang, M, Herman, J G, Hooker, C M, Watkins, D N, Karim, B, Huso, D L, Baylin, S B

“…Adenomatous polyposis coli ( APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with…”
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Analysis of Adenomatous polyposis coli promoter hypermethylation in human cancer by ESTELLER, M, SPARKS, A, BAYLIN, S. B, HERMAN, J. G, TOYOTA, M, SANCHEZ-CESPEDES, M, CAPELLA, G, PEINADO, M. A, GONZALEZ, S, TARAFA, G, SIDRANSKY, D, MELTZER, S. J

“…Germ-line mutations in the tumor suppressor gene APC are associated with hereditary familial adenomatous polyposis (FAP), and somatic mutations are common in…”
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Methylation-Specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands by Herman, James G., Graff, Jeremy R., Myöhänen, Sanna, Nelkin, Barry D., Baylin, Stephen B.

“…Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes such as the regulation of…”
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Mlh1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas by ESTELLER, M, LEVINE, R, BAYLIN, S. B, ELLENSON, L. H, HERMAN, J. G

“…Microsatellite instability (MSI) has been detected in endometrial carcinomas occurring in women affected by hereditary nonpolyposis colorectal carcinoma…”
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