BLOOD BRAIN BARRIER IN RIGHT- AND LEFT-PAWED FEMALE RATS ASSESSED BY A NEW STAINING METHOD

The asymmetrical breakdown of the blood-brain barrier (BBB) was studied in female rats. Paw preference was assessed by a food reaching test. Adrenaline-induced hypertension was used to destroy the BBB, which was evaluated using triphenyltetrazolium (TTC) staining of the brain slices just after givin...

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Bibliographic Details
Published in:	International journal of neuroscience Vol. 112; no. 9; pp. 1037 - 1046
Main Authors:	KUTLU, NECIP, VATANSEVER, H. SEDA, BAYAZIT, T. ONUR, EKERBICER, NURAN, TAN, UNER
Format:	Journal Article
Language:	English
Published:	London Informa UK Ltd 01-09-2002 Taylor & Francis
Subjects:	Animals Biological and medical sciences Blood Brain Barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Brain Brain - anatomy & histology Brain - drug effects Brain - physiology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral Laterality Coloring Agents Epinephrine - pharmacology Feeding Behavior Female Forelimb - physiology Functional Laterality Fundamental and applied biological sciences. Psychology Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Paw Preference Rat Rats Rats, Wistar Staining and Labeling - methods Tetrazolium Salts Vertebrates: nervous system and sense organs Motor pathway Rodentia Central nervous system Rattus norvegicus Blood brain barrier Blood flow Handedness Vertebrata Mammalia Cerebral hemisphere Motor cortex Muridae Hemodynamics Laterality Brain (vertebrata)
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Summary:	The asymmetrical breakdown of the blood-brain barrier (BBB) was studied in female rats. Paw preference was assessed by a food reaching test. Adrenaline-induced hypertension was used to destroy the BBB, which was evaluated using triphenyltetrazolium (TTC) staining of the brain slices just after giving adrenaline for 30 s. In normal rats, the whole brain sections exhibited complete staining with TTC. After adrenaline infusion for 30 s, there were large unstained areas in the left brain in right-pawed animals, and vice versa in left-pawed animals. Similar results were obtained in seizure-induced breakdown of BBB. These results were explained by an asymmetric cerebral blood flow depending upon the paw preference in rats. It was suggested that this new method and the results are consistent with contralateral motor control that may be important in determining the dominant cerebral hemisphere in animals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7454 1563-5279 1543-5245
DOI:	10.1080/00207450290026030