Search Results - "BAVARI, Sina"

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses by Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

“…The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history with over 28,000 cases, resulting in >11,000 deaths including >500…”
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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines by Luban, Jeremy, Sattler, Rachel A., Mühlberger, Elke, Graci, Jason D., Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Colacino, Joseph M., Bavari, Sina, Strambio-De-Castillia, Caterina, Suder, Ellen L., Wang, Yetao, Soloveva, Veronica, Cintron-Lue, Katherine, Naryshkin, Nikolai A., Pykett, Mark, Welch, Ellen M., O’Keefe, Kylie, Kong, Ronald, Goodwin, Elizabeth, Jacobson, Allan, Paessler, Slobodan, Peltz, Stuart W.

“…•COVID-19 is typified by SARS-CoV-2 replication and an excessive inflammatory response.•PTC299 is a small orally bioavailable DHODH inhibitor that blocks…”
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BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease by Taylor, Raymond, Kotian, Pravin, Warren, Travis, Panchal, Rekha, Bavari, Sina, Julander, Justin, Dobo, Sylvia, Rose, Angela, El-Kattan, Yahya, Taubenheim, Brian, Babu, Yarlagadda, Sheridan, William P

“…Summary The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening…”
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Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication by Tsai, Yien Che, Kotiya, Archana, Kiris, Erkan, Yang, Mei, Bavari, Sina, Tessarollo, Lino, Oyler, George A., Weissman, Allan M.

“…Botulism is characterized by flaccid paralysis, which can be caused by intoxication with any of the seven known serotypes of botulinum neurotoxin (BoNT), all…”
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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus by Huang, I-Chueh, Bailey, Charles C, Weyer, Jessica L, Radoshitzky, Sheli R, Becker, Michelle M, Chiang, Jessica J, Brass, Abraham L, Ahmed, Asim A, Chi, Xiaoli, Dong, Lian, Longobardi, Lindsay E, Boltz, Dutch, Kuhn, Jens H, Elledge, Stephen J, Bavari, Sina, Denison, Mark R, Choe, Hyeryun, Farzan, Michael

“…Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by…”
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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon by Smith, Darci R, Hollidge, Bradley, Daye, Sharon, Zeng, Xiankun, Blancett, Candace, Kuszpit, Kyle, Bocan, Thomas, Koehler, Jeff W, Coyne, Susan, Minogue, Tim, Kenny, Tara, Chi, Xiaoli, Yim, Soojin, Miller, Lynn, Schmaljohn, Connie, Bavari, Sina, Golden, Joseph W

“…Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice…”
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The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus by Jasenosky, Luke D., Cadena, Cristhian, Mire, Chad E., Borisevich, Viktoriya, Haridas, Viraga, Ranjbar, Shahin, Nambu, Aya, Bavari, Sina, Soloveva, Veronica, Sadukhan, Supriya, Cassell, Gail H., Geisbert, Thomas W., Hur, Sun, Goldfeld, Anne E.

“…Here, we show that the US Food and Drug Administration-approved oral drug nitazoxanide (NTZ) broadly amplifies the host innate immune response to viruses and…”
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A systematic screen of FDA-approved drugs for inhibitors of biological threat agents by Madrid, Peter B, Chopra, Sidharth, Manger, Ian D, Gilfillan, Lynne, Keepers, Tiffany R, Shurtleff, Amy C, Green, Carol E, Iyer, Lalitha V, Dilks, Holli Hutcheson, Davey, Robert A, Kolokoltsov, Andrey A, Carrion, Jr, Ricardo, Patterson, Jean L, Bavari, Sina, Panchal, Rekha G, Warren, Travis K, Wells, Jay B, Moos, Walter H, Burke, Raelyn L, Tanga, Mary J

“…The rapid development of effective medical countermeasures against potential biological threat agents is vital. Repurposing existing drugs that may have…”
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Rational design of small molecules as vaccine adjuvants by Wu, Tom Y-H, Singh, Manmohan, Miller, Andrew T, De Gregorio, Ennio, Doro, Francesco, D'Oro, Ugo, Skibinski, David A G, Mbow, M Lamine, Bufali, Simone, Herman, Ann E, Cortez, Alex, Li, Yongkai, Nayak, Bishnu P, Tritto, Elaine, Filippi, Christophe M, Otten, Gillis R, Brito, Luis A, Monaci, Elisabetta, Li, Chun, Aprea, Susanna, Valentini, Sara, Calabrό, Samuele, Laera, Donatello, Brunelli, Brunella, Caproni, Elena, Malyala, Padma, Panchal, Rekha G, Warren, Travis K, Bavari, Sina, O'Hagan, Derek T, Cooke, Michael P, Valiante, Nicholas M

“…Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major…”
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Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway by Brahms, Ashwini, Mudhasani, Rajini, Pinkham, Chelsea, Kota, Krishna, Nasar, Farooq, Zamani, Rouzbeh, Bavari, Sina, Kehn-Hall, Kylene

“…There is an urgent need for therapeutic development to combat infections caused by Rift Valley fever virus (RVFV), which causes devastating disease in both…”
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HSPA5 is an essential host factor for Ebola virus infection by Patrick Reid, St, Shurtleff, Amy C., Costantino, Julie A., Tritsch, Sarah R., Retterer, Cary, Spurgers, Kevin B., Bavari, Sina

“…•Targeting HSPA5 chaperone activity inhibits EBOV.•EBOV transcript and protein production is impaired in the absence of HSPA5.•Targeting HSPA5 in vivo protects…”
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IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus by Mudhasani, Rajini, Tran, Julie P, Retterer, Cary, Radoshitzky, Sheli R, Kota, Krishna P, Altamura, Louis A, Smith, Jeffrey M, Packard, Beverly Z, Kuhn, Jens H, Costantino, Julie, Garrison, Aura R, Schmaljohn, Connie S, Huang, I-Chueh, Farzan, Michael, Bavari, Sina

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus by Haddow, Andrew D, Nalca, Aysegul, Rossi, Franco D, Miller, Lynn J, Wiley, Michael R, Perez-Sautu, Unai, Washington, Samuel C, Norris, Sarah L, Wollen-Roberts, Suzanne E, Shamblin, Joshua D, Kimmel, Adrienne E, Bloomfield, Holly A, Valdez, Stephanie M, Sprague, Thomas R, Principe, Lucia M, Bellanca, Stephanie A, Cinkovich, Stephanie S, Lugo-Roman, Luis, Cazares, Lisa H, Pratt, William D, Palacios, Gustavo F, Bavari, Sina, Pitt, M Louise, Nasar, Farooq

“…Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk…”
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Ebola virus uses clathrin-mediated endocytosis as an entry pathway by Bhattacharyya, Suchita, Warfield, Kelly L, Ruthel, Gordon, Bavari, Sina, Aman, M. Javad, Hope, Thomas J

“…Abstract Ebola virus (EBOV) infects several cell types and while viral entry is known to be pH-dependent, the exact entry pathway(s) remains unknown. To gain…”
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Ebolavirus Glycoprotein Fc Fusion Protein Protects Guinea Pigs against Lethal Challenge by Konduru, Krishnamurthy, Shurtleff, Amy C, Bradfute, Steven B, Nakamura, Siham, Bavari, Sina, Kaplan, Gerardo

“…Ebola virus (EBOV), a member of the Filoviridae that can cause severe hemorrhagic fever in humans and nonhuman primates, poses a significant threat to the…”
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Advanced antisense therapies for postexposure protection against lethal filovirus infections by Iversen, Patrick L, Bavari, Sina, Warren, Travis K, Warfield, Kelly L, Wells, Jay, Swenson, Dana L, Donner, Kelly S, Van Tongeren, Sean A, Garza, Nicole L, Dong, Lian, Mourich, Dan V, Crumley, Stacy, Nichols, Donald K

“…Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral…”
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African and Asian Zika Virus Isolates Display Phenotypic Differences Both In Vitro and In Vivo by Smith, Darci R, Sprague, Thomas R, Hollidge, Bradley S, Valdez, Stephanie M, Padilla, Susana L, Bellanca, Stephanie A, Golden, Joseph W, Coyne, Susan R, Kulesh, David A, Miller, Lynn Jean, Haddow, Andrew D, Koehler, Jeff W, Gromowski, Gregory D, Jarman, Richard G, Alera, Maria Theresa P, Yoon, In-Kyu, Buathong, Rome, Lowen, Robert G, Kane, Christopher D, Minogue, Timothy D, Bavari, Sina, Tesh, Robert B, Weaver, Scott C, Linthicum, Kenneth J, Pitt, Margaret L, Nasar, Farooq

“…Zika virus (ZIKV) is a mosquito-borne member of the genus that has emerged since 2007 to cause outbreaks in Africa, Asia, Oceania, and most recently, in the…”
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AVI-7288 for Marburg Virus in Nonhuman Primates and Humans by Heald, Alison E, Charleston, Jay S, Iversen, Patrick L, Warren, Travis K, Saoud, Jay B, Al-Ibrahim, Mohamed, Wells, Jay, Warfield, Kelly L, Swenson, Dana L, Welch, Lisa S, Sazani, Peter, Wong, Michael, Berry, Diane, Kaye, Edward M, Bavari, Sina

“…In this study, a potential therapy for Marburg virus infection was assessed by means of a lethal challenge in nonhuman primates, and key pharmacokinetic data…”
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3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells by Felts, Richard L., Narayan, Kedar, Estes, Jacob D., Shi, Dan, Trubey, Charles M., Fu, Jing, Hartnell, Lisa M., Ruthel, Gordon T., Schneider, Douglas K., Nagashima, Kunio, Bess, Julian W., Bavari, Sina, Lowekamp, Bradley C., Bliss, Donald, Lifson, Jeffrey D., Subramaniam, Sriram, Moss, Bernard

“…The efficiency of HIV infection is greatly enhanced when the virus is delivered at conjugates between CD4⁺ T cells and virus-bearing antigen-presenting cells…”
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Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus by Warren, Travis K., Kane, Christopher D., Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Steffens, Jesse, Gomba, Laura, Weidner, Jessica M., Norris, Sarah, Zeng, Xiankun, Bannister, Roy, Cihlar, Tomas, Bavari, Sina, Porter, Danielle P., Iversen, Patrick L.

“…Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular,…”
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