Search Results - "BAUER, Stefanie"
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Sir2 and Reb1 antagonistically regulate nucleosome occupancy in subtelomeric X-elements and repress TERRAs by distinct mechanisms
Published in PLoS genetics (22-09-2022)“…Telomere chromatin structure is pivotal for maintaining genome stability by regulating the binding of telomere-associated proteins and inhibiting the DNA…”
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Helicase/SUMO-targeted ubiquitin ligase Uls1 interacts with the Holliday junction resolvase Yen1
Published in PloS one (21-03-2019)“…Resolution of branched DNA structures is pivotal for repair of stalled replication forks and meiotic recombination intermediates. The Yen1 nuclease cleaves…”
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Structural basis of small-molecule inhibition of human multidrug transporter ABCG2
Published in Nature structural & molecular biology (01-04-2018)“…ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to…”
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The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture
Published in Particle and fibre toxicology (19-09-2024)“…The formation of secondary organic aerosols (SOA) by atmospheric oxidation reactions substantially contributes to the burden of fine particulate matter (PM ),…”
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Automated online safety margin (GLIOVIS) for glioma surgery model
Published in Frontiers in oncology (29-04-2024)“…Glioblastoma is the most common type of primary brain malignancy and has a poor prognosis. The standard treatment strategy is based on maximal safe surgical…”
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Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells
Published in Journal of Virology (01-12-2010)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V
Published in The Journal of biological chemistry (07-10-2011)“…The cold-sensitive single-residue mutation of glycine 680 in the reactive thiol region of Dictyostelium discoideum myosin-2 or the corresponding conserved…”
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Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air-Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs)
Published in Environmental health perspectives (01-02-2022)“…Secondary organic aerosols (SOAs) formed from anthropogenic or biogenic gaseous precursors in the atmosphere substantially contribute to the ambient fine…”
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Adenine derivatization for LC-MS/MS epigenetic DNA modifications studies on monocytic THP-1 cells exposed to reference particulate matter
Published in Analytical biochemistry (01-04-2021)“…The aim of this study was to explore the impact of three different standard reference particulate matter (ERM-CZ100, SRM-1649, and SRM-2975) on epigenetic DNA…”
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Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP)
Published in European journal of medicinal chemistry (01-04-2020)“…Tariquidar derivatives have been described as potent and selective ABCG2 inhibitors. However, their susceptibility to hydrolysis limits their applicability…”
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A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform
Published in Journal of virology (01-11-2015)“…In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of…”
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In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air–liquid interface in exposure concentrations relevant at workplaces
Published in Environmental and molecular mutagenesis (01-11-2021)“…The ubiquitous use of phthalates in various materials and the knowledge about their potential adverse effects is of great concern for human health. Several…”
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A comparative study of persistent DNA oxidation and chromosomal instability induced in vitro by oxidizers and reference airborne particles
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01-02-2022)“…•PM metal content increases lipid peroxidation induction.•Different reference airborne PM induce DNA oxidation in a similar extend.•PAHs derivatives augment…”
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Genotoxic and inflammatory effects of spruce and brown coal briquettes combustion aerosols on lung cells at the air-liquid interface
Published in The Science of the total environment (01-02-2022)“…Solid fuel usage in residential heating and cooking is one of the largest sources of ambient and indoor air particulate matter, which causes adverse effects on…”
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Is the particle deposition in a cell exposure facility comparable to the lungs? A computer model approach
Published in Aerosol science and technology (02-06-2020)“…Cell exposure experiments at the air-liquid interface (ALI) are used increasingly as indicators for health effects and for the impact of aerosols on the lung…”
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Air quality intervention during the Nanjing youth olympic games altered PM sources, chemical composition, and toxicological responses
Published in Environmental research (01-06-2020)“…Ambient particulate matter (PM) is a leading global environmental health risk. Current air quality regulations are based on airborne mass concentration…”
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Atmospheric aging increases the cytotoxicity of bare soot particles in BEAS-2B lung cells
Published in Aerosol science and technology (04-05-2023)“…Soot particles (SP) are ubiquitous components of atmospheric particulate matter and have been shown to cause various adverse health effects. In the atmosphere,…”
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Biological impact of sequential exposures to allergens and ultrafine particle‐rich combustion aerosol on human bronchial epithelial BEAS‐2B cells at the air liquid interface
Published in Journal of applied toxicology (01-08-2023)“…The prevalence of allergic diseases is constantly increasing since few decades. Anthropogenic ultrafine particles (UFPs) and allergenic aerosols is highly…”
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Processing of carbon-reinforced construction materials releases PM2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts
Published in Environmental toxicology and pharmacology (01-03-2023)“…Building demolition following domestic fires or abrasive processing after thermal recycling can release particles harmful for the environment and human health…”
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