Search Results - "BATRAKOVA, E. V"

Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion by BATRAKOVA, E. V, LI, S, ELMQUIST, W. F, MILLER, D. W, ALAKHOV, V. Y, KABANOV, A. V

“…This paper, for the first time, demonstrates that exposure of cells to the poly(ethylene oxide)-poly(propylene oxide) block copolymer, Pluronic P85, results in…”
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New technologies for drug delivery across the blood brain barrier by Kabanov, A V, Batrakova, E V

“…The blood-brain barrier (BBB) efficiently restricts penetration of therapeutic agents to the brain from the periphery. Therefore, discovery of new modalities…”
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Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers by BATRAKOVA, E. V, SHU LI, MILLER, D. W, KABANOV, A. V

“…Previous studies demonstrated that inhibition of P glycoprotein (P-gp) by Pluronic P85 (P85) block copolymer increases apical (AP) to basolateral (BL)…”
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Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles : in vivo evaluation of anti-cancer activity by BATRAKOVA, E. V, DORODNYCH, T. Y, KLINSKII, E. Y, KLIUSHNENKOVA, E. N, SHEMCHUKOVA, O. B, GONCHAROVA, O. N, ARJAKOV, S. A, ALAKHOV, V. Y, KABANOV, A. V

“…The chemosensitising effects of poly(ethylene oxide)-poly(propylene oxide)-poly-(ethylene oxide) (PEO-PPO-PEO) block copolymers (Pluronic) in…”
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Effects of Pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells by BATRAKOVA, E. V, HAN, H.-Y, MILLER, D. W, KABANOV, A. V

“…Using polarized bovine brain microvessel endothelial cells (BBMEC) monolayers as in vitro model of the blood brain barrier and Caco-2 monolayers as a model of…”
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Inhibition of multidrug resistance-associated protein (MRP) functional activity with Pluronic block copolymers by MILLER, D. W, BATRAKOVA, E. V, KABANOV, A. V

“…Using monolayers of human pancreatic adenocarcinoma cells (Panc-1) that express multidrug resistance-associated protein (MRP), the present work investigates…”
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Effects of Pluronic block copolymers on drug absorption in Caco-2 cell monolayers by BATRAKOVA, E. V, HAN, H.-Y, ALAKHOV, V. Yu, MILLER, D. W, KABANOV, A. V

“…The present work characterizes the effects of Pluronic copolymers on the transport of a P-gp-dependent probe, rhodamine 123 (R123) in Caco-2 cell monolayers…”
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Cell-mediated drug delivery to the brain by Batrakova, E.V., Kabanov, A.V.

“…The inability of most potent therapeutics to cross the blood–brain barrier following systemic administration necessitates the need to develop unconventional,…”
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The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: Micelles as microcontainers for drug targeting by Kabanov, A.V., Chekhonin, V.P., Alakhov, V.Yu, Batrakova, E.V., Lebedev, A.S., Melik-Nubarov, N.S., Arzhakov, S.A., Levashov, A.V., Morozov, G.V., Severin, E.S., Kabanov, V.A.

“…It has been suggested to use surfactant micelles as microcontainers for increasing the efficiency of neuroleptic targeting from blood flow into the brain. The…”
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An essential relationship between ATP depletion and chemosensitizing activity of Pluronic ® block copolymers by Kabanov, Alexander V., Batrakova, Elena V., Yu. Alakhov, Valery

“…Pluronic ® block copolymers are known to sensitize multidrug resistant (MDR) tumors with respect to various anticancer agents, particularly, anthracycline…”
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Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization by Batrakova, E V, Li, S, Vinogradov, S V, Alakhov, V Y, Miller, D W, Kabanov, A V

“…Pluronic block copolymer, P85, inhibits the P-glycoprotein (Pgp) drug efflux system and increases the permeability of a broad spectrum of drugs in the…”
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Relationship between Pluronic Block Copolymer Structure, Critical Micellization Concentration and Partitioning Coefficients of Low Molecular Mass Solutes by Kozlov, Mikhail Yu, Melik-Nubarov, Nikolai S, Batrakova, Elena V, Kabanov, Alexander V

“…Using pyrene and homologous alkyl derivatives of fluorescein as fluorescent probes, this work examines the partitioning coefficients of hydrophobic solutes in…”
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Distribution kinetics of a micelle-forming block copolymer Pluronic P85 by Batrakova, Elena V., Li, Shu, Li, Yili, Alakhov, Valery Yu, Elmquist, William F., Kabanov, Alexander V.

“…Pluronic block copolymers, micelle-forming polymeric surfactants, are currently being evaluated in chemotherapy clinical trials in combination with doxorubicin…”
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Nanogels for Oligonucleotide Delivery to the Brain by Vinogradov, Serguei V, Batrakova, Elena V, Kabanov, Alexander V

“…Systemic delivery of oligonucleotides (ODN) to the central nervous system is needed for development of therapeutic and diagnostic modalities for treatment of…”
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Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies by Batrakova, E V, Miller, D W, Li, S, Alakhov, V Y, Kabanov, A V, Elmquist, W F

“…Drug delivery across the blood-brain barrier is limited by several mechanisms. One important mechanism is drug efflux, mediated by several transport proteins,…”
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Polypeptide Point Modifications with Fatty Acid and Amphiphilic Block Copolymers for Enhanced Brain Delivery by Batrakova, Elena V, Vinogradov, Serguei V, Robinson, Sandra M, Niehoff, Michael L, Banks, William A, Kabanov, Alexander V

“…There is a tremendous need to enhance delivery of therapeutic polypeptides to the brain to treat disorders of the central nervous system (CNS). The brain…”
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Micelle Formation and Solubilization of Fluorescent Probes in Poly(oxyethylene-b-oxypropylene-b-oxyethylene) Solutions by Kabanov, Alexander V, Nazarova, Irina R, Astafieva, Irina V, Batrakova, Elena V, Alakhov, Valery Yu, Yaroslavov, Alexander A, Kabanov, Victor A

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Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer by Alakhov, Valery Yu, Moskaleva, Elizaveta Yu, Batrakova, Elena V, Kabanov, Alexander V

“…The chemosensitizing effects of Pluronic P85 block copolymer were studied using two human ovarian carcinoma sublines:  the glycoprotein P (P-gp) multidrug…”
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Mixed Polymer Micelles of Amphiphilic and Cationic Copolymers for Delivery of Antisense Oligonucleotides by Vinogradov, Serguei V., Batrakova, Elena V., Li, Shu, Kabanov, Alexander V.

“…Cationic copolymers were synthesized by conjugation of branched 2 kDa polyethylenimine (PEI) and Pluronic® block copolymers (F38, P85, P123). Compositions of…”
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Interactions of Pluronic Block Copolymers with Brain Microvessel Endothelial Cells:  Evidence of Two Potential Pathways for Drug Absorption by Miller, Donald W, Batrakova, Elena V, Waltner, Timothy O, Alakhov, Valery Yu, Kabanov, Alexander V

“…Pluronic block copolymers have been previously reported to increase the delivery of agents to the brain [Kabanov et al. (1992) J. Controlled Release 22,…”
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