Search Results - "BATHGATE, ROSS A.D."

Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin by Fernando, Shalinda J A, Wang, Qian, Hay, Debbie L, Bathgate, Ross A D, Shepherd, Peter R, Lee, Kate L

“…RXFP4 is a G protein-coupled receptor (GPCR) in the relaxin family. It has recently been recognised that this receptor and its cognate ligand INSL5 may have a…”
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Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats by Xu, Qi, Chakravorty, Arindam, Bathgate, Ross A.D, Dart, Anthony M, Du, Xiao-Jun

“…Hypertension and aging are associated with large artery structural remodeling and stiffening, which are known to increase cardiovascular risk. Relaxin is a…”
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Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats by Lekgabe, Edna D, Kiriazis, Helen, Zhao, Chongxin, Xu, Qi, Moore, Xiao Lei, Su, Yidan, Bathgate, Ross A.D, Du, Xiao-Jun, Samuel, Chrishan S

“…The antifibrotic effects of the peptide hormone relaxin on cardiac and renal fibrosis were studied in 9- to 10-month-old male spontaneously hypertensive rats…”
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The A-chain of Human Relaxin Family Peptides Has Distinct Roles in the Binding and Activation of the Different Relaxin Family Peptide Receptors by Hossain, Mohammed Akhter, Rosengren, K. Johan, Haugaard-Jönsson, Linda M., Zhang, Soude, Layfield, Sharon, Ferraro, Tania, Daly, Norelle L., Tregear, Geoffrey W., Wade, John D., Bathgate, Ross A.D.

“…The relaxin peptides are a family of hormones that share a structural fold characterized by two chains, A and B, that are cross-braced by three disulfide…”
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Expression of the Insulin-Like Peptide 3 (INSL3) Hormone-Receptor (LGR8) System in the Testis by Anand-Ivell, Ravinder J.K, Relan, Vandana, Balvers, Marga, Coiffec-Dorval, Isabelle, Fritsch, Martin, Bathgate, Ross A.D, Ivell, Richard

“…The new peptide hormone insulin-like peptide 3 (INSL3) is a member of the insulin-relaxin family, yet, unlike insulin, it signals through a new G-protein…”
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Solution Structure and Characterization of the LGR8 Receptor Binding Surface of Insulin-like Peptide 3 by Rosengren, K. Johan, Zhang, Suode, Lin, Feng, Daly, Norelle L., Scott, Daniel J., Hughes, Richard A., Bathgate, Ross A.D., Craik, David J., Wade, John D.

“…Insulin-like peptide 3 (INSL3), a member of the relaxin peptide family, is produced in testicular Leydig cells and ovarian thecal cells. Gene knock-out…”
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Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist by Haugaard-Jönsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A.D., Wade, John D., Craik, David J., Rosengren, K. Johan

“…The human relaxin family comprises seven peptide hormones with various biological functions mediated through interactions with G-protein-coupled receptors…”
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Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity by Muda, Marco, He, Chaomei, Martini, Paolo G.V., Ferraro, Tania, Layfield, Sharon, Taylor, Deanne, Chevrier, Colette, Schweickhardt, Rene, Kelton, Christie, Ryan, Peter L., Bathgate, Ross A.D.

“…LGR7 and LGR8 are G protein-coupled receptors that belong to the leucine-rich repeat-containing G-protein coupled receptor (LGR) family, including the…”
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The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting by Bathgate, Ross A.D., Kocan, Martina, Scott, Daniel J., Hossain, M. Akhter, Good, Sara V., Yegorov, Sergey, Bogerd, Jan, Gooley, Paul R.

“…The peptide relaxin was first identified as an important circulating hormone during pregnancy over 90 years ago. Research over many years defined the numerous…”
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Spawning induction of the high-value white teatfish sea cucumber, Holothuria fuscogilva, using recombinant relaxin-like gonad stimulating peptide (RGP) by Nocillado, Josephine, Duy, Nguyen Dinh Quang, Chieu, Hoang Dinh, Turner, Luke, Bathgate, Ross A.D., Wang, Tianfang, Hossain, Mohammed Akhter, Hung, Nguyen Van, Ninh, Nguyen Huu, Cummins, Scott F., Elizur, Abigail

“…We have previously shown in Holothuria leucospilota the maturation-inducing role of the neurohormone relaxin-like gonad-stimulating peptide (RGP). Here, we…”
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Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis by Chow, Bryna S Man, Kocan, Martina, Bosnyak, Sanja, Sarwar, Mohsin, Wigg, Belinda, Jones, Emma S, Widdop, Robert E, Summers, Roger J, Bathgate, Ross A D, Hewitson, Tim D, Samuel, Chrishan S

“…Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic…”
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A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY by Scott, Daniel J., Gunn, Natalie J., Yong, Kelvin J., Wimmer, Verena C., Veldhuis, Nicholas A., Challis, Leesa M., Haidar, Mouna, Petrou, Steven, Bathgate, Ross A. D., Griffin, Michael D. W.

“…Recent advances in thick tissue clearing are enabling high resolution, volumetric fluorescence imaging of complex cellular networks. Fluorescent proteins (FPs)…”
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Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1) by Bumbak, Fabian, Pons, Miquel, Inoue, Asuka, Paniagua, Juan Carlos, Yan, Fei, Wu, Hongwei, Robson, Scott A., Bathgate, Ross A.D., Scott, Daniel J., Gooley, Paul R., Ziarek, Joshua J.

“…Nuclear magnetic resonance (NMR) studies have revealed that fast methyl sidechain dynamics can report on entropically-driven allostery. Yet, NMR applications…”
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Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches by Wu, Feng-Jie, Williams, Lisa M., Abdul-Ridha, Alaa, Gunatilaka, Avanka, Vaid, Tasneem M., Kocan, Martina, Whitehead, Alice R., Griffin, Michael D.W., Bathgate, Ross A.D., Scott, Daniel J., Gooley, Paul R.

“…G protein–coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an allosteric network encompassing…”
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Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies by Bumbak, Fabian, Keen, Alastair C., Gunn, Natalie J., Gooley, Paul R., Bathgate, Ross A.D., Scott, Daniel J.

“…Neurotensin is a 13-residue peptide that acts as a neuromodulator of classical neurotransmitters such as dopamine and glutamate in the mammalian central…”
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Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation by Banerjee, Avantika, Shen, Pei-Juan, Ma, Sherie, Bathgate, Ross A D, Gundlach, Andrew L

“…Relaxin-3 (RLX3), a newly identified member of the relaxin peptide family, is distinguished by its enriched expression in GABA projection neurons of the…”
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The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy by Alam, Fariha, Gaspari, Tracey A., Kemp-Harper, Barbara K., Low, Edward, Aw, Aaron, Ferens, Dorota, Spizzo, Iresha, Jefferis, Ann-Maree, Praveen, Praveen, Widdop, Robert E., Bathgate, Ross A.D., Hossain, Mohammed Akhter, Samuel, Chrishan S.

“…The hormone, relaxin (RLX), exerts various organ-protective effects independently of etiology. However, its complex two-chain and three disulphide bonded…”
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Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1 by Shabanpoor, Fazel, Akhter Hossain, Mohammad, Ryan, Philip J, Belgi, Alessia, Layfield, Sharon, Kocan, Martina, Zhang, Suode, Samuel, Chrishan S, Gundlach, Andrew L, Bathgate, Ross A.D, Separovic, Frances, Wade, John D

“…Relaxin-3 is a neuropeptide that is implicated in the regulation of stress responses and memory. The elucidation of its precise physiological role­(s) has,…”
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Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain by Smith, Craig M., Shen, Pei-Juan, Banerjee, Avantika, Bonaventure, Pascal, Ma, Sherie, Bathgate, Ross A.D., Sutton, Steven W., Gundlach, Andrew L.

“…Relaxin‐3 (RLN3) and its native receptor, relaxin family peptide 3 receptor (RXFP3), constitute a newly identified neuropeptide system enriched in mammalian…”
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High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist by Lin, Guangyao, Feng, Yang, Cai, Xiaoqing, Zhou, Caihong, Shao, Lijun, Chen, Yan, Chen, Linhai, Liu, Qing, Zhou, Qingtong, Bathgate, Ross A D, Yang, Dehua, Wang, Ming-Wei

“…Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogenous ligand relaxin-3 are…”
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