Ivermectin : concentration-dependent effects on adenosine triphosphatases in adult worms of Onchocerca volvulus

The effect of increasing concentrations of ivermectin on adenosine triphosphatase (ATPase) activity was investigated in adult worms of Onchocerca volvulus. Mean Mg- and Na,K-ATPase activities decreased significantly (F ratio = 29.82, P < 0.01 and F ratio = 28.54, P < 0.01, respectively) with i...

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Bibliographic Details
Published in:	Acta tropica Vol. 74; no. 1; pp. 7 - 11
Main Authors:	SHU, E. N, OKONKWO, P. O, BATEY, W. O, ONYEANUSI, J
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier 05-01-2000
Subjects:	Adenosine Triphosphatases - drug effects Adenosine Triphosphatases - metabolism Adult Analysis of Variance Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiprotozoal Agents - pharmacology Biological and medical sciences Diseases caused by nematodes Dose-Response Relationship, Drug Female Filariases Helminthic diseases Humans Infectious diseases Ivermectin - pharmacology Male Medical sciences Nigeria Onchocerca volvulus - drug effects Onchocerca volvulus - enzymology Onchocercosis Parasitic diseases Pharmacology. Drug treatments Tropical medicine Nigeria Africa Human Skin disease Anthelmintic Enzyme Adenosinetriphosphatase Onchocerca volvulus Parasitosis Helminthiasis Onchocerciasis Biological activity Infection Eye disease Nematode disease Parasiticid Helmintha Hydrolases Nemathelminthia Filariosis Invertebrata Nematoda Ivermectin
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Summary:	The effect of increasing concentrations of ivermectin on adenosine triphosphatase (ATPase) activity was investigated in adult worms of Onchocerca volvulus. Mean Mg- and Na,K-ATPase activities decreased significantly (F ratio = 29.82, P < 0.01 and F ratio = 28.54, P < 0.01, respectively) with increasing concentrations of ivermectin (0-100 ng/ml) in the female worms. When male and female worms were mixed with equal amounts of proteins from each, only the Na,K-ATPase activity was significantly decreased (F ratio = 56.61, P < 0.01) over a similar range of ivermectin concentrations. Since ivermectin exhibits concentration-dependent effects on both ATPases in female adult worms, this might provide an insight into other effects of the drug. However, the adjustment of the dose of ivermectin to obtain a nodular concentration of at least 40 ng/ml is therefore recommended in the complete chemotherapy of onchocerciasis.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0001-706X 1873-6254
DOI:	10.1016/S0001-706X(99)00052-2