Search Results - "BASTACKY, Sheldon I"

Diabetic kidney diseases revisited: A new perspective for a new era by Fu, Haiyan, Liu, Silvia, Bastacky, Sheldon I., Wang, Xiaojie, Tian, Xiao-Jun, Zhou, Dong

“…Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a…”
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Early activation of fibroblasts is required for kidney repair and regeneration after injury by Zhou, Dong, Fu, Haiyan, Liu, Shijia, Zhang, Lu, Xiao, Liangxiang, Bastacky, Sheldon I., Liu, and Youhua

“…Acute kidney injury (AKI) is a devastating condition with high morbidity and mortality. AKI is characterized by tubular injury, inflammation, and vascular…”
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Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice by Rush, Brittney M, Bondi, Corry D, Stocker, Sean D, Barry, Kacie M, Small, Sarah A, Ong, Jason, Jobbagy, Soma, Stolz, Donna B, Bastacky, Sheldon I, Chartoumpekis, Dionysios V, Kensler, Thomas W, Tan, Roderick J

“…The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway upregulates key cellular defenses. Clinical trials are utilizing pharmacologic Nrf2 inducers…”
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Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity by Levack, Russell C., Newell, Krista L., Cabrera-Martinez, Berenice, Cox, Justin, Perl, Andras, Bastacky, Sheldon I., Winslow, Gary M.

“…CD11c + T-bet + B cells are recognized as an important component of humoral immunity and autoimmunity. These cells can be distinguished from other B cells by…”
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Urinary K+ promotes irritative voiding symptoms and pain in the face of urothelial barrier dysfunction by Montalbetti, Nicolas, Stocker, Sean D., Apodaca, Gerard, Bastacky, Sheldon I., Carattino, Marcelo D.

“…The internal surface of the bladder is lined by the urothelium, a stratified epithelium that forms an impermeable barrier to water and urine constituents…”
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Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model by Gordon, Rachael A, Tilstra, Jeremy S, Marinov, Anthony, Nickerson, Kevin M, Bastacky, Sheldon I, Shlomchik, Mark J

“…Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of…”
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Increased urothelial paracellular transport promotes cystitis by Montalbetti, Nicolas, Rued, Anna C, Clayton, Dennis R, Ruiz, Wily G, Bastacky, Sheldon I, Prakasam, H Sandeep, Eaton, Amity F, Kullmann, F Aura, Apodaca, Gerard, Carattino, Marcelo D

“…Changes in the urothelial barrier are observed in patients with cystitis, but whether this leads to inflammation or occurs in response to it is currently…”
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Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis by Gui, Yuan, Wang, Yuanyuan, Palanza, Zachary, Wang, Jack L., Gupta, Priya, Tao, Jianling, Qiao, Yi, Hargis, Geneva, Kreutzer, Donald L., Bastacky, Sheldon I., Yu, Yanbao, Wang, Yanlin, Liu, Silvia, Fu, Haiyan, Zhou, Dong

“…In the fibrotic kidneys, the extent of a formed deleterious microenvironment is determined by cellular mechanical forces. This process requires metabolism for…”
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Lupus and proliferative nephritis are PAD4 independent in murine models by Gordon, Rachael A, Herter, Jan M, Rosetti, Florencia, Campbell, Allison M, Nishi, Hiroshi, Kashgarian, Michael, Bastacky, Sheldon I, Marinov, Anthony, Nickerson, Kevin M, Mayadas, Tanya N, Shlomchik, Mark J

“…Though recent reports suggest that neutrophil extracellular traps (NETs) are a source of antigenic nucleic acids in systemic lupus erythematosus (SLE), we…”
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Calponin 2 regulates ketogenesis to mitigate acute kidney injury by Gui, Yuan, Palanza, Zachary, Gupta, Priya, Li, Hanwen, Pan, Yuchen, Wang, Yuanyuan, Hargis, Geneva, Kreutzer, Donald L, Wang, Yanlin, Bastacky, Sheldon I, Liu, Yansheng, Liu, Silvia, Zhou, Dong

“…Calponin 2 (CNN2) is a prominent actin stabilizer. It regulates fatty acid oxidation (FAO) by interacting with estrogen receptor 2 (ESR2) to determine kidney…”
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Muc1 is protective during kidney ischemia-reperfusion injury by Pastor-Soler, Núria M, Sutton, Timothy A, Mang, Henry E, Kinlough, Carol L, Gendler, Sandra J, Madsen, Cathy S, Bastacky, Sheldon I, Ho, Jacqueline, Al-Bataineh, Mohammad M, Hallows, Kenneth R, Singh, Sucha, Monga, Satdarshan P, Kobayashi, Hanako, Haase, Volker H, Hughey, Rebecca P

“…Ischemia-reperfusion injury (IRI) due to hypotension is a common cause of human acute kidney injury (AKI). Hypoxia-inducible transcription factors (HIFs)…”
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Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis by Gordon, Rachael A, Giannouli, Christina, Raparia, Chirag, Bastacky, Sheldon I, Marinov, Anthony, Hawse, William, Cattley, Richard, Tilstra, Jeremy S, Campbell, Allison M, Nickerson, Kevin M, Davidson, Anne, Shlomchik, Mark J

“…NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses…”
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Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis by Kullmann, F Aura, McDonnell, Bronagh M, Wolf-Johnston, Amanda S, Lynn, Andrew M, Giglio, Daniel, Getchell, Samuel E, Ruiz, Wily G, Zabbarova, Irina V, Ikeda, Youko, Kanai, Anthony J, Roppolo, James R, Bastacky, Sheldon I, Apodaca, Gerard, Buffington, C A Tony, Birder, Lori A

“…Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic disease of unknown etiology. A naturally occurring disease termed feline…”
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Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors by Monzon, Federico A, Hagenkord, Jill M, Lyons-Weiler, Maureen A, Balani, Jyoti P, Parwani, Anil V, Sciulli, Christin M, Li, Jia, Chandran, Uma R, Bastacky, Sheldon I, Dhir, Rajiv

“…Renal tumors with complex or unusual morphology require extensive workup for accurate classification. Chromosomal aberrations that define subtypes of renal…”
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Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis by Zhou, Dong, Fu, Haiyan, Zhang, Lu, Zhang, Ke, Min, Yali, Xiao, Liangxiang, Lin, Lin, Bastacky, Sheldon I, Liu, Youhua

“…Cell-cell communication Wnt ligands is necessary in regulating embryonic development and has been implicated in CKD. Because Wnt ligands are ubiquitously…”
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Renal Cell Neoplasms Contain Shared Tumor Type–Specific Copy Number Variations by Krill-Burger, John M, Lyons, Maureen A, Kelly, Lori A, Sciulli, Christin M, Petrosko, Patricia, Chandran, Uma R, Kubal, Michael D, Bastacky, Sheldon I, Parwani, Anil V, Dhir, Rajiv, LaFramboise, William A

“…Copy number variant (CNV) analysis was performed on renal cell carcinoma (RCC) specimens (chromophobe, clear cell, oncocytoma, papillary type 1, and papillary…”
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Evaluation of whole slide image immunohistochemistry interpretation in challenging prostate needle biopsies by Fine, Jeffrey L., MD, Grzybicki, Dana M., MD, PhD, Silowash, Russell, BS, Ho, Jonhan, MD, Gilbertson, John R., MD, Anthony, Leslie, MA, Wilson, Robb, MA, Parwani, Anil V., MD, PhD, Bastacky, Sheldon I., MD, Epstein, Jonathan I., MD, Jukic, Drazen M., MD, PhD

“…Summary Whole slide images (WSIs), also known as virtual slides, can support electronic distribution of immunohistochemistry (IHC) stains to pathologists that…”
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CHRONIC NORADRENALINE INCREASES RENAL EXPRESSION OF NHE-3, NBC-1, BSC-1 AND AQUAPORIN-2 by Sonalker, Prajakta A, Tofovic, Stevan P, Bastacky, Sheldon I, Jackson, Edwin K

“…SUMMARY 1 Because chronic activation of the renal sympathetic nervous system promotes sodium and water retention, it is conceivable that long‐term exposure of…”
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Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis by Zhou, Dong, Wang, Yuanyuan, Gui, Yuan, Fu, Haiyan, Zhou, Shanshan, Wang, Yanlin, Bastacky, Sheldon I, Stolz, Donna B, Liu, Youhua

“…Activation of canonical Wnt signaling has been implicated in podocyte injury and proteinuria. As Wnts are secreted proteins, whether Wnts derived from…”
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Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice by Nickerson, Kevin M, Smita, Shuchi, Hoehn, Kenneth B, Marinov, Anthony D, Thomas, Kayla B, Kos, Justin T, Yang, Yi, Bastacky, Sheldon I, Watson, Corey T, Kleinstein, Steven H, Shlomchik, Mark J

“…Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of memory B cell (MBC) expressing the transcription factor…”
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