Search Results - "BASSISSI, Firas"

Hexasodium fytate exposure-response correlations in a randomized, placebo-controlled study of patients on dialysis with cardiovascular calcification by Perelló, Joan, Alberti, Joan, Torres, Juan Vicente, Ferrer, Miguel D, Perez, M Mar, Bassissi, Firas, Gold, Alex, Raggi, Paolo, Chertow, Glenn M, Salcedo, Carolina

“…Patients receiving dialysis have high cardiovascular risk in part due to extensive vascular calcification. In the CaLIPSO study, infusion of hexasodium fytate…”
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GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition by Bestion, Eloïne, Jilkova, Zuzana Macek, Mège, Jean-Louis, Novello, Marie, Kurma, Keerthi, Pour, Seyedeh Tayebeh Ahmad, Lalmanach, Gilles, Vanderlynden, Lise, Fizanne, Lionel, Bassissi, Firas, Rachid, Madani, Tracz, Jennifer, Boursier, Jérôme, Courcambeck, Jérôme, Serdjebi, Cindy, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe, Brun, Sonia

“…Background: Hepatic fibrosis is the result of chronic liver injury that can progress to cirrhosis and lead to liver failure. Nevertheless, there are no…”
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Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves by Vercruysse, Jozef, Deprez, Piet, Everaert, Dries, Bassissi, Firas, Alvinerie, Michel

“…Belgian Blue (BB) cattle are very sensitive to mange caused by Psoroptes ovis and, in contrast to the case in Holstein cattle, single treatments with…”
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Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics by FIRAS BASSISSI, Mohamad, ALVINERIE, Michel, MARTIN, Pascal Guy Pierre, FERRET, Bertrand, LESPINE, Anne

“…We studied the influence of dyslipemia on the distribution of moxidectin, a potent antiparasitic drug of the macrocyclic lactone (ML) family, in plasma…”
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The FIPO23 trial: First-in-human phase I/II study of XON7 in advanced solids tumors by Bennouna, Jaafar, Shneiker, Françoise, BLAY, Jean Yves, Awada, Ahmad, Bassissi, Firas, Ratta, Raffaele, Delord, Jean-Pierre

“…TPS2673 Background: XON7 is a first-in-class glyco-humanized polyclonal antibody (GH-pAb) targeting selectively multiple tumor-associated antigens. XON7…”
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Macrocyclic lactones: distribution in plasma lipoproteins of several animal species including humans by Bassissi, Mohamad Firas, Alvinerie, Michel, Lespine, Anne

“…We studied the in vitro distribution of macrocyclic lactones (MLs), lipophilic anthelmintic drugs, in the plasma of several animal species including humans…”
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SNF472 Improves Limb Blood Perfusion and Walking Ability and Inhibits Progression of Calcification in Femoral Arteries in a Rat Model of Peripheral Artery Disease by Bassissi, Firas, Ferrer, Miguel D., Perez, M. Mar, Blasco, Marc, Perelló, Joan, Salcedo, Carolina

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FC 107SNF472 ATTENUATES THE PROGRESSION OF FEMORAL ARTERY CALCIFICATION AND RECOVERS LIMB BLOOD PERFUSION AND WALKING ABILITY IN A RAT MODEL OF PERIPHERAL ARTERY DISEASE by Bassissi, Firas, Ferrer Reynes, Miguel David, Pérez, M Mar, Blasco, Marc, Perelló, Joan, Salcedo, Carolina

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Abstract 2739: XON27, a novel and potent immunotherapy against hematologic malignancies by Ciron, Carine, Morice, Pierre, Shneiker, Françoise, Duvaux, Odile, Bassissi, Firas

“…Background: Over the past decades, intensive research has led to the development of innovative therapies (monoclonal and bispecific antibodies, CAR T cells)…”
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GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions by Brun, Sonia, Bestion, Eloïne, Raymond, Eric, Bassissi, Firas, Jilkova, Zuzana Macek, Mezouar, Soraya, Rachid, Madani, Novello, Marie, Tracz, Jennifer, Hamaï, Ahmed, Lalmanach, Gilles, Vanderlynden, Lise, Legouffe, Raphael, Stauber, Jonathan, Schubert, Thomas, Plach, Maximilian G., Courcambeck, Jérôme, Drouot, Cyrille, Jacquemot, Guillaume, Serdjebi, Cindy, Roth, Gael, Baudoin, Jean-Pierre, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe

“…Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date,…”
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Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration by Bassissi, Firas, Lespine, Anne, Alvinerie, Michel

“…Ivermectin is a member of the macrocyclic lactone family widely used in livestock, pets, and humans as a potent parasiticide. Slight differences in formulation…”
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Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs by Lespine, Anne, Chanoit, Guillaume, Bousquet-Melou, Alain, Lallemand, Elodie, Bassissi, Firas Mohamad, Alvinerie, Michel, Toutain, Pierre-Louis

“…Moxidectin, a macrocyclic lactone (ML), is a potent parasiticide widely used in veterinary medicine and currently under development for use in humans. The…”
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P1234SNF472 IMPROVES LIMB BLOOD PERFUSION AND WALKING ABILITY IN A PERIPHERAL ARTERY DISEASE VASCULAR CALCIFICATION RAT MODEL by Bassissi, Firas, Ferrer Reynes, Miguel David, Pérez, M Mar, Perelló, Joan, Salcedo, Carolina

“…Abstract Background and Aims Peripheral Artery disease (PAD) is a common vascular disease associated with functional impairment and increased risk of…”
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P0884MYO-INOSITOL HEXAPHOSPHATE PEGYLATION IMPROVES BIOAVAILABILITY BUT REDUCES ITS ANTI-VASCULAR CALCIFICATION EFFECT IN RATS by Pérez, M Mar, Ferrer Reynes, Miguel David, Ortega-Castro, Joaquín, Bassissi, Firas, Perelló, Joan, Salcedo, Carolina

“…Abstract Background and Aims Vascular calcification (VC) is a major contributor to increased morbidity and mortality in End Stage Kidney Disease (ESKD)…”
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Pharmacokinetics, Pharmacodynamics (PK-PD), and Exposure-Efficacy Evaluation from CaLIPSO, a Phase 2B Study to Assess the Effect of SNF472 on Progression of Cardiovascular Calcification in Patients on Hemodialysis: PO1142 by Perelló, Joan, Alberti, Joan J., Martin, Juan Vicente Torres, del mar Perez, Maria, Ferrer, Miquel D., Bassissi, Firas, Salcedo, Carolina

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Assessment of Vascular Calcification Using Micro-CT Quantification in a Vitamin D Rat Model: PO0527 by Bassissi, Firas, Sabador, David, Ferrer, Marc Blasco, Perez, Guillermo Garaulet, Perez, Maria del mar, Ferrer, Miquel D., Mulero, Francisca, Salcedo, Carolina

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GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma by Brun, Sonia, Bassissi, Firas, Serdjebi, Cindy, Novello, Marie, Tracz, Jennifer, Autelitano, François, Guillemot, Marie, Fabre, Philippe, Courcambeck, Jérôme, Ansaldi, Christelle, Raymond, Eric, Halfon, Philipe

“…Summary Among the acquired modifications in cancer cells, changes in lysosomal phenotype and functions are well described, making lysosomes a potential target…”
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Clinical significance of high expression of a specific solute carrier transporter in HCC by Gifu, Patricia, Brun, Sonia, Wang, Guanxiong, Bassissi, Firas, Caron de Fromentel, Claude, Merle, Philippe, Halfon, Philippe

“…Abstract only 303 Background: Hepatocellular carcinoma (HCC) is the third cause of cancer-related death. GNS561 (Genoscience Pharma, France) is a small…”
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Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration by FIRAS BASSISSI, Mohamad, LESPINE, Anne, ALVINERIE, Michel

“…Moxidectin is a member of the macrocyclic lactone family of drugs widely used for the control of internal and external parasites. Because moxidectin is highly…”
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Abstract 2737: LIS22, a first in class polyclonal antibody immunotherapy in T cell blood cancers by Ciron, Carine, Shneiker, Francoise, Dauphouy, Ophélie, Rousse, Juliette, Royer, Pierre-Joseph, Evanno, Gwenaelle, Duvaux, Odile, Bassissi, Firas

“…Background: Several approaches such as antibody drug conjugate (ADC), chimeric antigen receptor T cells (CAR-T) and recently bispecific antibodies are being…”
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