Search Results - "BASRUR, Venkatesha"

Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors by Djomehri, Sabra I., Gonzalez, Maria E., da Veiga Leprevost, Felipe, Tekula, Shilpa R., Chang, Hui-Yin, White, Marissa J., Cimino-Mathews, Ashley, Burman, Boris, Basrur, Venkatesha, Argani, Pedram, Nesvizhskii, Alexey I., Kleer, Celina G.

“…Metaplastic breast carcinoma (MBC) is a highly aggressive form of triple-negative cancer (TNBC), defined by the presence of metaplastic components of spindle,…”
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Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation by Mukherjee, Sandip, Kumar, Ritesh, Tsakem Lenou, Elviche, Basrur, Venkatesha, Kontoyiannis, Dimitris L., Ioakeimidis, Fotis, Mosialos, George, Theiss, Arianne L., Flavell, Richard A., Venuprasad, K.

“…The inflammasome NLRP6 plays a crucial role in regulating inflammation and host defense against microorganisms in the intestine. However, the molecular…”
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Autoinhibited kinesin-1 adopts a hierarchical folding pattern by Tan, Zhenyu, Yue, Yang, Leprevost, Felipe, Haynes, Sarah, Basrur, Venkatesha, Nesvizhskii, Alexey I, Verhey, Kristen J, Cianfrocco, Michael A

“…Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of…”
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Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway by Boyer, Seth, Lee, Ho-Joon, Steele, Nina, Zhang, Li, Sajjakulnukit, Peter, Andren, Anthony, Ward, Matthew H, Singh, Rima, Basrur, Venkatesha, Zhang, Yaqing, Nesvizhskii, Alexey I, Pasca di Magliano, Marina, Halbrook, Christopher J, Lyssiotis, Costas A

“…The pancreatic ductal adenocarcinoma microenvironment is composed of a variety of cell types and marked by extensive fibrosis and inflammation…”
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p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis by Anwar, Talha, Arellano-Garcia, Caroline, Ropa, James, Chen, Yu-Chih, Kim, Hong Sun, Yoon, Euisik, Grigsby, Sierrah, Basrur, Venkatesha, Nesvizhskii, Alexey I., Muntean, Andrew, Gonzalez, Maria E., Kidwell, Kelley M., Nikolovska-Coleska, Zaneta, Kleer, Celina G.

“…Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes metastasis. EZH2 has been mainly studied as the catalytic component of the…”
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SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2 by Singh, Amir Kumar, Khare, Prashant, Obaid, Abeer, Conlon, Kevin P., Basrur, Venkatesha, DePinho, Ronald A., Venuprasad, K.

“…Dysregulated ROR-γt-mediated IL-17 transcription is central to the pathogenesis of several inflammatory disorders, yet the molecular mechanisms that govern the…”
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The Ewing Sarcoma Secretome and Its Response to Activation of Wnt/beta-catenin Signaling by Hawkins, Allegra G., Basrur, Venkatesha, da Veiga Leprevost, Felipe, Pedersen, Elisabeth, Sperring, Colin, Nesvizhskii, Alexey I., Lawlor, Elizabeth R.

“…Tumor: tumor microenvironment (TME) interactions are critical for tumor progression and the composition and structure of the local extracellular matrix (ECM)…”
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An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain by Cao, Fang, Chen, Yong, Cierpicki, Tomasz, Liu, Yifan, Basrur, Venkatesha, Lei, Ming, Dou, Yali

“…Histone H3 lysine 4 (K4) methylation is a prevalent mark associated with transcription activation and is mainly catalyzed by the MLL/SET1 family histone…”
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Abacus: A computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis by Fermin, Damian, Basrur, Venkatesha, Yocum, Anastasia K., Nesvizhskii, Alexey I.

“…We describe Abacus, a computational tool for extracting spectral counts from MS/MS data sets. The program aggregates data from multiple experiments, adjusts…”
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Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry by Korwar, Arvind M., Shay, Ashley E., Basrur, Venkatesha, Conlon, Kevin, Prabhu, K. Sandeep

“…Selenium (Se) functions as a cellular redox gatekeeper through its incorporation into proteins as the 21st amino acid, selenocysteine (Sec). Supplementation of…”
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Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents by Park, Sung-Soo, Ponce-Balbuena, Daniela, Kuick, Rork, Guerrero-Serna, Guadalupe, Yoon, Justin, Mellacheruvu, Dattatreya, Conlon, Kevin P., Basrur, Venkatesha, Nesvizhskii, Alexey I., Jalife, José, Rual, Jean-François

“…A comprehensive map of the Kir2.1 interactome was generated using the proximity-labeling approach BioID. The map encompasses 218 interactions, the vast…”
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Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes by Biswas, Debabrata, Milne, Thomas A, Basrur, Venkatesha, Kim, Jaehoon, Elenitoba-Johnson, Kojo S. J, Allis, C. David, Roeder, Robert G

“…A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion partners that have been reported…”
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Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury by Park, Min-Jung, D’Alecy, Louis G., Anderson, Michelle A., Basrur, Venkatesha, Feng, Yongjia, Brady, Graham F., Kim, Dong-il, Wu, Jun, Nesvizhskii, Alexey I., Lahann, Joerg, Lukacs, Nicholas W., Fontana, Robert J., Omary, M. Bishr

“…Carbamoyl phosphate synthetase-1 (CPS1) is the major mitochondrial urea cycle enzyme in hepatocytes. It is released into mouse and human blood during acute…”
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RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control by Mohan, Harihar Milaganur, Trzeciakiewicz, Hanna, Pithadia, Amit, Crowley, Emily V., Pacitto, Regina, Safren, Nathaniel, Trotter, Bryce, Zhang, Chengxin, Zhou, Xiaogen, Zhang, Yang, Basrur, Venkatesha, Paulson, Henry L., Sharkey, Lisa M.

“…The brain-expressed ubiquilins (UBQLNs) 1, 2 and 4 are a family of ubiquitin adaptor proteins that participate broadly in protein quality control (PQC)…”
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RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation by Singh, Amir Kumar, Kumar, Ritesh, Yin, Jianyi, Brooks II, John F., Kathania, Mahesh, Mukherjee, Sandip, Kumar, Jitendra, Conlon, Kevin P., Basrur, Venkatesha, Chen, Zhe, Han, Xianlin, Hooper, Lora V., Burstein, Ezra, Venuprasad, K.

“…Th17 cells that produce Interleukin IL-17 are pathogenic in many human diseases, including inflammatory bowel disease, but are, paradoxically, essential for…”
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MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia by Crump, Nicholas T., Smith, Alastair L., Godfrey, Laura, Dopico-Fernandez, Ana M., Denny, Nicholas, Harman, Joe R., Hamley, Joseph C., Jackson, Nicole E., Chahrour, Catherine, Riva, Simone, Rice, Siobhan, Kim, Jaehoon, Basrur, Venkatesha, Fermin, Damian, Elenitoba-Johnson, Kojo, Roeder, Robert G., Allis, C. David, Roberts, Irene, Roy, Anindita, Geng, Huimin, Davies, James O. J., Milne, Thomas A.

“…Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome…”
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Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis by Milne, Thomas A., Kim, Jaehoon, Wang, Gang G., Stadler, Sonja C., Basrur, Venkatesha, Whitcomb, Sarah J., Wang, Zhanxin, Ruthenburg, Alexander J., Elenitoba-Johnson, Kojo S.J., Roeder, Robert G., Allis, C. David

“…MLL1 fusion proteins activate HoxA9 gene expression and cause aggressive leukemias that respond poorly to treatment, but how they recognize and stably bind to…”
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The mechanism of cancer drug addiction in ALK-positive T-Cell lymphoma by Rajan, Soumya S., Amin, Amit Dipak, Li, Lingxiao, Rolland, Delphine C., Li, Haiquan, Kwon, Deukwoo, Kweh, Mercedes F., Arumov, Artavazd, Roberts, Evan R., Yan, Aimin, Basrur, Venkatesha, Elenitoba-Johnson, Kojo S. J., Chen, Xi Steven, Puvvada, Soham D., Lussier, Yves A., Bilbao, Daniel, Lim, Megan S., Schatz, Jonathan H.

“…Rational new strategies are needed to treat tumors resistant to kinase inhibitors. Mechanistic studies of resistance provide fertile ground for development of…”
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KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation by Shukla, Shirish, Allam, Uday Sankar, Ahsan, Aarif, Chen, Guoan, Krishnamurthy, Pranathi Meda, Marsh, Katherine, Rumschlag, Matthew, Shankar, Sunita, Whitehead, Christopher, Schipper, Matthew, Basrur, Venkatesha, Southworth, Daniel R, Chinnaiyan, Arul M, Rehemtulla, Alnawaz, Beer, David G, Lawrence, Theodore S, Nyati, Mukesh K, Ray, Dipankar

“…Abstract Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of Smad ubiquitination regulatory factor 2 (SMURF2) and…”
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Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117 by Todi, Sokol V., Scaglione, K. Matthew, Blount, Jessica R., Basrur, Venkatesha, Conlon, Kevin P., Pastore, Annalisa, Elenitoba-Johnson, Kojo, Paulson, Henry L.

“…Deubiquitinating enzymes (DUbs) play important roles in many ubiquitin-dependent pathways, yet how DUbs themselves are regulated is not well understood. Here,…”
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