Search Results - "BARTUS, R. T"

On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis by Bartus, Raymond T.

“…Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its topographic possibilities… while science is the compass that keeps…”
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Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies by Bartus, R.T, Kordower, J.H, Johnson, E.M, Brown, L, Kruegel, B.R, Chu, Y, Baumann, T.L, Lang, A.E, Olanow, C.W, Herzog, C.D

“…Abstract Substantial interest persists for developing neurotrophic factors to treat neurodegenerative diseases. At the same time, significant progress has been…”
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Enhanced delivery of carboplatin into brain tumours with intravenous Cereport (RMP-7): dramatic differences and insight gained from dosing parameters by EMERICH, D. F, SNODGRASS, P, DEAN, R, AGOSTINO, M, HASLER, B, PINK, M, XIONG, H, KIM, B. S, BARTUS, R. T

“…Cereport (RMP-7) is a selective bradykinin B2 receptor agonist which increases the permeability of the 'blood-brain tumour barrier' (BBTB) to increase delivery…”
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The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier from concept to clinical evaluation by EMERICH, Dwaine F, DEAN, Reginald L, OSBORN, Chester, BARTUS, Raymond T

“…Labradimil (Cereport; also formerly referred to as RMP-7) is a 9-amino-acid peptide designed for selectivity for the bradykinin B2 receptor and a longer plasma…”
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Controlled Modulation of BBB Permeability Using the Bradykinin Agonist, RMP-7 by Bartus, R.T., Elliott, P.J., Dean, R.L., Hayward, N.J., Nagle, T.L., Huff, M.R., Snodgrass, P.A., Blunt, D.G.

“…Previous studies have shown that the bradykinin agonist, RMP-7, can safely permeabilize the blood brain barrier (BBB) by activation of constitutive B2…”
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Calpain Inhibitor AK295 Attenuates Motor and Cognitive Deficits Following Experimental Brain Injury in the Rat by Saatman, Kathryn E., Murai, Hisayuki, Bartus, Raymond T., Smith, Douglas H., Hayward, Neil J., Perri, Brian R., McIntosh, Tracy K.

“…Marked increases in intracellular calcium may play a role in mediating cellular dysfunction and death following central nervous system trauma, in part through…”
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Sustained Delivery of Proteins for Novel Therapeutic Products by Bartus, Raymond T., Tracy, Mark A., Emerich, Dwaine F., Zale, Stephen E.

“…New protein therapies have been developed for many conditions, including hepatitis C, multiple sclerosis and various cancers…”
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Injectable chemotherapeutic microspheres and glioma. II : Enhanced survival following implantation into deep inoperable tumors by EMERICH, D. F, WINN, S. R, SNODGRASS, P, LAFRENIERE, D, AGOSTINO, M, WIENS, T, HUA XIONG, BARTUS, R. T

“…Delivery of chemotherapeutics using implantable, biodegradable polymers provides a potentially powerful method of treating brain tumors. The present studies…”
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Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors by ELLIOTT, P. J, HAYWARD, N. J, DEAN, R. L, BLUNT, D, BARTUS, R. T

“…Rats implanted with RG-2 gliomas were administered i.v. RMP-7 and [14C]carboplatin. Changes in the permeability of the blood-brain barrier to carboplatin were…”
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Injectable chemotherapeutic microspheres and glioma. I : Enhanced survival following implantation into the cavity wall of debulked tumors by EMERICH, D. F, WINN, S. R, YUNHUA HU, MARSH, J, SNODGRASS, P, LAFRENIERE, D, WIENS, T, HASLER, B. P, BARTUS, R. T

“…Implantation of biodegradable polymers provides a powerful method to deliver high, sustained concentrations of chemotherapeutics to brain tumors. The present…”
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Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors by Inamura, T, Nomura, T, Bartus, R T, Black, K L

“…The bradykinin analog, RMP-7, was investigated for its ability to selectively increase uptake of molecular tracers in RG2 glial tumors. When infused in low…”
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Behavioral Efficacy of Posttraumatic Calpain Inhibition Is Not Accompanied by Reduced Spectrin Proteolysis, Cortical Lesion, or Apoptosis by Saatman, Kathryn E., Zhang, Chen, Bartus, Raymond T., McIntosh, Tracy K.

“…Administration of the selective calpain inhibitor AK295 has been shown to attenuate motor and cognitive dysfunction after brain trauma in rats. To explore…”
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Pathway across blood-brain barrier opened by the bradykinin agonist, RMP-7 by Sanovich, Elena, Bartus, Raymond T., Friden, Phillip M., Dean, Reginald L., Le, Harrison Q., Brightman, Milton W.

“…The route taken by lanthanum (MW 139) across cerebral endothelium was delineated when the blood-brain barrier was opened by RMP-7, a novel bradykinin agonist…”
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Unlocking the Blood–Brain Barrier: A Role for RMP-7 in Brain Tumor Therapy by Elliott, Peter J., Hayward, Neil J., Huff, Michael R., Nagle, Tricia L., Black, Keith L., Bartus, Raymond T.

“…The effect and mechanism of the blood–brain barrier-permeabilizing agent, RMP-7, was investigated in a series of studies employing a rat RG2 glioma model…”
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Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage by Bartus, R T, Baker, K L, Heiser, A D, Sawyer, S D, Dean, R L, Elliott, P J, Straub, J A

“…Experiments were conducted to determine whether a potent, reversible calpain inhibitor could reduce the cortical ischemic brain damage associated with focal…”
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Central analgesic actions of loperamide following transient permeation of the blood brain barrier with Cereport™ (RMP-7) by Emerich, Dwaine F, Snodgrass, Pamela, Pink, Melissa, Bloom, Floyd, Bartus, Raymond T

“…The bradykinin analog, Cereport™ (RMP-7), was designed to increase permeability of the blood brain barrier (BBB). Over the past several years it has been…”
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Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain by Bartus, R T, Dean, R L, Cavanaugh, K, Eveleth, D, Carriero, D L, Lynch, G

“…Changes in neocortex and striatum were characterized over time following focal ischemia to the brain. Rats were subjected to permanent middle cerebral artery…”
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Suppression of alcohol intake by chronic naloxone treatment in P rats : Tolerance development and elevation of opiate receptor binding by OVERSTREET, D. H, KAMPOV-POLEVOY, A. B, REZVANI, A. H, BRAUN, C, BARTUS, R. T, CREWS, F. T

“…This study was planned to determine the feasibility of using a slow release naloxone preparation to treat alcoholism, because compliance with medication is a…”
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Intravenous Administration of a Transferrin Receptor Antibody-Nerve Growth Factor Conjugate Prevents the Degeneration of Cholinergic Striatal Neurons in a Model of Huntington Disease by Kordower, Jeffrey H., Charles, Vinod, Bayer, Robert, Bartus, Raymond T., Putney, Scott, Walus, Lee R., Friden, Phillip M.

“…Intrastriatal injections of quinolinic acid induce a pattern of neuronal degeneration similar to that seen in Huntington disease. In the present study, nerve…”
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Temporal ordering of pathogenic events following transient global ischemia by Bartus, Raymond T., Dean, Reginald L., Mennerick, Steve, Eveleth, David, Lynch, Gary

“…Rats were subjected to transient global ischemia (four vessel occlusion) and time-related changes in the selectively vulnerable hippocampal field CA1 were…”
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