Search Results - "BARTER, Z. E"

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling by BARTER, Z. E, CHOWDRY, J. E, HARLOW, J. R, SNAWDER, J. E, LIPSCOMB, J. C, ROSTAMI-HODJEGAN, A

“…Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed cytochrome P450 enzymes to predict human hepatic clearance requires…”
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Determination of a quantitative relationship between hepatic CYP3A51/3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations by Barter, Z. E., Perrett, H. F., Yeo, K. Rowland, Allorge, D., Lennard, M. S., Rostami-Hodjegan, A.

“…The creation of virtual populations allows the estimation of pharmacokinetic parameters, such as metabolic clearance in extreme individuals rather than the…”
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Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes by PERRETT, H. F, BARTER, Z. E, JONES, B. C, YAMAZAKI, H, TUCKER, G. T, ROSTAMI-HODJEGAN, A

“…An analysis of reported hepatic abundances of CYP3A4 and 3A5 indicated that values determined by immunoquantification using commercially available, unpurified…”
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Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors by Crewe, H. K., Barter, Z. E., Rowland Yeo, K., Rostami-Hodjegan, A.

“…ABSTRACT The ‘relative activity factor’ (RAF) compares the activity per unit of microsomal protein in recombinantly expressed cytochrome P450 enzymes (rhCYP)…”
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