Search Results - "BARTELINK, H"
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A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade
Published in Scientific reports (02-08-2019)“…Over the past decade, several immunotherapies have been approved for the treatment of melanoma. The most prominent of these are the immune checkpoint…”
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SP-0192: Biomarkers and the prediction of outcome in breast conserving therapy
Published in Radiotherapy and oncology (01-03-2013)Get full text
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A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer
Published in The AAPS journal (24-06-2019)“…Immunotherapy and immune checkpoint blocking antibodies such as anti-PD-1 are approved and significantly improve the survival of advanced non-small cell lung…”
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SP-0137 AGAINST THE MOTION
Published in Radiotherapy and oncology (01-05-2012)Get full text
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Modelling mixed forest growth: a review of models for forest management
Published in Ecological modelling (15-04-2002)“…Most forests today are multi-specific and heterogeneous forests (‘mixed forests’). However, forest modelling has been focusing on mono-specific stands for a…”
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Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis
Published in The lancet oncology (01-05-2021)“…Randomised, controlled trials and meta-analyses have shown the survival benefit of concomitant chemoradiotherapy or hyperfractionated radiotherapy in the…”
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Battling the obesity epidemic with a school-based intervention: Long-term effects of a quasi-experimental study
Published in PloS one (27-09-2022)“…Background School-based health-promoting interventions are increasingly seen as an effective population strategy to improve health and prevent obesity…”
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Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis
Published in The Lancet. Haematology (01-11-2016)“…Summary Background Intravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell…”
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Busulfan target exposure attainment in children undergoing allogeneic hematopoietic cell transplantation: a single day versus a multiday therapeutic drug monitoring regimen
Published in Bone marrow transplantation (Basingstoke) (01-07-2023)“…Busulfan exposure has previously been linked to clinical outcomes, hence the need for therapeutic drug monitoring (TDM). Study objective was to evaluate the…”
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Population Pharmacokinetic Modeling of Thymoglobulin® in Children Receiving Allogeneic-Hematopoietic Cell Transplantation: Towards Improved Survival Through Individualized Dosing
Published in Clinical pharmacokinetics (01-04-2015)“…Background and Objectives To prevent graft-versus-host disease and rejection in hematopoietic cell transplantation (HCT), children receive Thymoglobulin ® , a…”
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Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial
Published in Critical care (London, England) (08-06-2023)“…A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase…”
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Highly Variable Plasma Concentrations of Voriconazole in Pediatric Hematopoietic Stem Cell Transplantation Patients
Published in Antimicrobial Agents and Chemotherapy (01-01-2013)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0-1 non-small cell lung cancer: the INCREASE trial
Published in BMC cancer (14-08-2020)“…The likelihood of a tumor recurrence in patients with T3-4N0-1 non-small cell lung cancer following multimodality treatment remains substantial, mainly due…”
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In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model
Published in Royal Society open science (01-05-2019)“…The low response rate of immune checkpoint blockade in breast cancer has highlighted the need for predictive biomarkers to identify responders. While a number…”
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Long-Term Risk of Cardiovascular Disease in 10-Year Survivors of Breast Cancer
Published in JNCI : Journal of the National Cancer Institute (07-03-2007)“…Background Radiotherapy for breast cancer as delivered in the 1970s has been associated with increased risk of cardiovascular disease, but recent studies of…”
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Very low local recurrence rates after breast-conserving therapy: analysis of 8485 patients treated over a 28-year period
Published in Breast cancer research and treatment (01-04-2016)“…The purpose of this study was to study the impact of changes in clinical practice on outcome in patients treated with breast-conserving therapy (BCT) over a…”
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SP-0060: Image and biological guided adaptive radiotherapy; results from the ARTFORCE project
Published in Radiotherapy and oncology (01-04-2015)Get full text
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Process evaluation of the healthy primary School of the Future: the key learning points
Published in BMC public health (06-06-2019)“…While schools have potential to contribute to children's health and healthy behaviour, embedding health promotion within complex school systems is challenging…”
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Optimizing Antiviral Dosing for HSV and CMV Treatment in Immunocompromised Patients
Published in Pharmaceutics (03-01-2023)“…Herpes simplex virus (HSV) and cytomegalovirus (CMV) are DNA viruses that are common among humans. Severely immunocompromised patients are at increased risk of…”
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Quantitative Characterization of CD8+ T Cell Clustering and Spatial Heterogeneity in Solid Tumors
Published in Frontiers in oncology (07-01-2019)“…Quantitative characterization of the tumor microenvironment, including its immuno-architecture, is important for developing quantitative diagnostic and…”
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