Search Results - "BARTEL, David P"

lincRNAs: Genomics, Evolution, and Mechanisms by Ulitsky, Igor, Bartel, David P.

“…Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in mammalian genomes and might play widespread roles in gene regulation and…”
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RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria by Guo, Junjie U., Bartel, David P.

“…In vitro, some RNAs can form stable four-stranded structures known as G-quadruplexes. Although RNA G-quadruplexes have been implicated in posttranscriptional…”
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A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain by Kleaveland, Benjamin, Shi, Charlie Y., Stefano, Joanna, Bartel, David P.

“…Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles. Here, we describe a regulatory network centered on four ncRNAs—a long ncRNA, a…”
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MicroRNAs: Target Recognition and Regulatory Functions by Bartel, David P.

“…MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes…”
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Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance by Denzler, Rémy, Agarwal, Vikram, Stefano, Joanna, Bartel, David P., Stoffel, Markus

“…Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes…”
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Expanded identification and characterization of mammalian circular RNAs by Guo, Junjie U, Agarwal, Vikram, Guo, Huili, Bartel, David P

“…The recent reports of two circular RNAs (circRNAs) with strong potential to act as microRNA (miRNA) sponges suggest that circRNAs might play important roles in…”
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Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution by Ulitsky, Igor, Shkumatava, Alena, Jan, Calvin H., Sive, Hazel, Bartel, David P.

“…Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic…”
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The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes by Fang, Wenwen, Bartel, David P.

“…MicroRNAs (miRNAs) are small regulatory RNAs processed from stem-loop regions of primary transcripts (pri-miRNAs), with the choice of stem loops for initial…”
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Widespread Influence of 3′-End Structures on Mammalian mRNA Processing and Stability by Wu, Xuebing, Bartel, David P.

“…The physiological relevance of structures within mammalian mRNAs has been elusive, as these mRNAs are less folded in cells than in vitro and have predicted…”
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Principles of Long Noncoding RNA Evolution Derived from Direct Comparison of Transcriptomes in 17 Species by Hezroni, Hadas, Koppstein, David, Schwartz, Matthew G., Avrutin, Alexandra, Bartel, David P., Ulitsky, Igor

“…The inability to predict long noncoding RNAs from genomic sequence has impeded the use of comparative genomics for studying their biology. Here, we develop…”
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Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing by Auyeung, Vincent C., Ulitsky, Igor, McGeary, Sean E., Bartel, David P.

“…To use microRNAs to downregulate mRNA targets, cells must first process these ∼22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA…”
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The molecular basis of coupling between poly(A)-tail length and translational efficiency by Xiang, Kehui, Bartel, David P

“…In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between…”
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The biochemical basis of microRNA targeting efficacy by McGeary, Sean E, Lin, Kathy S, Shi, Charlie Y, Pham, Thy M, Bisaria, Namita, Kelley, Gina M, Bartel, David P

“…MicroRNAs (miRNAs) act within Argonaute proteins to guide repression of messenger RNA targets. Although various approaches have provided insight into target…”
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MicroRNA Clustering Assists Processing of Suboptimal MicroRNA Hairpins through the Action of the ERH Protein by Fang, Wenwen, Bartel, David P

“…Microprocessor initiates the processing of microRNAs (miRNAs) from the hairpin regions of primary transcripts (pri-miRNAs). Pri-miRNAs often contain multiple…”
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kpLogo: positional k-mer analysis reveals hidden specificity in biological sequences by Wu, Xuebing, Bartel, David P

“…Motifs of only 1-4 letters can play important roles when present at key locations within macromolecules. Because existing motif-discovery tools typically miss…”
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Predicting effective microRNA target sites in mammalian mRNAs by Agarwal, Vikram, Bell, George W, Nam, Jin-Wu, Bartel, David P

“…MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical…”
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Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression by Denzler, Rémy, McGeary, Sean E., Title, Alexandra C., Agarwal, Vikram, Bartel, David P., Stoffel, Markus

“…Expression changes of competing endogenous RNAs (ceRNAs) have been proposed to influence microRNA (miRNA) activity and thereby regulate other transcripts…”
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Excised linear introns regulate growth in yeast by Morgan, Jeffrey T., Fink, Gerald R., Bartel, David P.

“…Spliceosomal introns are ubiquitous non-coding RNAs that are typically destined for rapid debranching and degradation. Here we describe 34 excised introns in…”
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mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues by Eichhorn, Stephen W., Guo, Huili, McGeary, Sean E., Rodriguez-Mias, Ricard A., Shin, Chanseok, Baek, Daehyun, Hsu, Shu-hao, Ghoshal, Kalpana, Villén, Judit, Bartel, David P.

“…MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at…”
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Poly(A)-tail profiling reveals an embryonic switch in translational control by Subtelny, Alexander O., Eichhorn, Stephen W., Chen, Grace R., Sive, Hazel, Bartel, David P.

“…Poly(A) tails enhance the stability and translation of most eukaryotic messenger RNAs, but difficulties in globally measuring poly(A)-tail lengths have impeded…”
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