Search Results - "BARROW, W. W"

Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1 by Bourne, C R, Barrow, E W, Bunce, R A, Bourne, P C, Berlin, K D, Barrow, W W

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Neuroimaging of Intracerebral Hemorrhage by Rindler, Rima S, Allen, Jason W, Barrow, Jack W, Pradilla, Gustavo, Barrow, Daniel L

“…Abstract Intracerebral hemorrhage (ICH) accounts for 10% to 20% of strokes worldwide and is associated with high morbidity and mortality rates. Neuroimaging is…”
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Comprehensive review of imaging of intracranial aneurysms and angiographically negative subarachnoid hemorrhage by Howard, Brian M, Hu, Ranliang, Barrow, Jack W, Barrow, Daniel L

“…Intracranial aneurysms confer the risk of subarachnoid hemorrhage (SAH), a potentially devastating condition, though most aneurysms will remain asymptomatic…”
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John Rensenbrink, 1928-2022: In Memoriam by Barrow, Clyde W.

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Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti‐programmed cell death 1 therapy by Marano, A.L., Clarke, J.M., Morse, M.A., Shah, A., Barrow, W., Selim, M.A., Hall, R.P., Cardones, A.R.

“…Summary Programmed cell death 1 (PD‐1) blockade has rapidly emerged as an effective therapy for a wide variety of metastatic malignancies. It has been…”
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Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity by BOURNE, Christina R, BUNCE, Richard A, BOURNE, Philip C, DARRELL BERLIN, K, BARROW, Esther W, BARROW, William W

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Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex by Muddala, Nagendra Prasad, Nammalwar, Baskar, Selvaraju, Subhashini, Bourne, Christina R, Henry, Mary, Bunce, Richard A, Berlin, K Darrell, Barrow, Esther W, Barrow, William W

“…The synthesis and evaluation of ten new dihydrophthalazine-appended 2,4-diaminopyrimidines as potential drugs to treat Bacillus anthracis is reported. An…”
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Antimycobacterial Activities of 2,4-Diamino-5-Deazapteridine Derivatives and Effects on Mycobacterial Dihydrofolate Reductase by SULING, William J, SEITZ, Lainne E, PATHAK, Vibha, WESTBROOK, Louise, BARROW, Esther W, ZYWNO-VAN-GINKEL, Sabrina, REYNOLDS, Robert C, PIPER, J. Robert, BARROW, William W

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In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis by BARROW, Esther W, DREIER, Jürg, REINELT, Stefan, BOURNE, Philip C, BARROW, William W

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Identification of Novel Potential Antibiotics against Staphylococcus Using Structure-Based Drug Screening Targeting Dihydrofolate Reductase by Kobayashi, Maiko, Kinjo, Tomohiro, Koseki, Yuji, Bourne, Christina R, Barrow, William W, Aoki, Shunsuke

“…The emergence of multidrug-resistant Staphylococcus aureus (S. aureus) makes the treatment of infectious diseases in hospitals more difficult and increases the…”
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Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis by Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.

“…A series of substituted 2,4-diaminopyrimidines 1 has been prepared and evaluated for activity against Bacillus anthracis using previously reported…”
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SCLE and dermatomyositis in anti‐PD‐1 therapy by Marano, A.L., Clarke, J.M., Morse, M.A., Shah, A., Barrow, W., Selim, M.A., Hall, R.P., Cardones, A.R.

“…Summary PD‐1 inhibitors are a relatively new type of drug that are used to treat patients with metastatic (widespread) cancers. Examples include drugs called…”
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Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis by Nammalwar, Baskar, Muddala, N Prasad, Bourne, Christina R, Henry, Mary, Bourne, Philip C, Bunce, Richard A, Barrow, Esther W, Berlin, K Darrell, Barrow, William W

“…Due to the innate ability of bacteria to develop resistance to available antibiotics, there is a critical need to develop new agents to treat more resilient…”
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Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis-Infected Macrophages by BARROW, E. L. W, WINCHESTER, G. A, STAAS, J. K, QUENELLE, D. C, BARROW, W. W

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Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis by Nammalwar, Baskar, Bourne, Christina R., Wakeham, Nancy, Bourne, Philip C., Barrow, Esther W., Muddala, N. Prasad, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.

“…[Display omitted] The current Letter describes the synthesis and biological evaluation of dihydrophthalazine-appended 2,4-diaminopyrimidine (DAP) inhibitors…”
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Functional Cloning of Bacillus anthracis Dihydrofolate Reductase and Confirmation of Natural Resistance to Trimethoprim by BARROW, Esther W, BOURNE, Philip C, BARROW, William W

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Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase by Bourne, Christina R., Wakeham, Nancy, Nammalwar, Baskar, Tseitin, Vladimir, Bourne, Philip C., Barrow, Esther W., Mylvaganam, Shankari, Ramnarayan, Kal, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.

“…Background: Bacterial resistance to antibiotic therapies is increasing and new treatment options are badly needed. There is an overlap between these resistant…”
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Antimycobacterial activity of 2-methyl-adenosine by Barrow, Esther W., Westbrook, Louise, Bansal, Namita, Suling, William J., Maddry, Joseph A., Parker, William B., Barrow, William W.

“…Objectives: The aims of this study were to assess the in vitro activity of 2-methyl-adenosine against Mycobacterium tuberculosis and evaluate, and to…”
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Microsphere technology for chemotherapy of mycobacterial infections by Barrow, William W

“…The purpose of this review article is to examine the various studies that have evaluated microspheres for delivery of antimycobacterial drugs. Some of the…”
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Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines by Nammalwar, Baskar, Bourne, Christina R., Bunce, Richard A., Wakeham, Nancy, Bourne, Philip C., Ramnarayan, Kal, Mylvaganam, Shankari, Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.

“…(±)‐6‐Alkyl‐2,4‐diaminopyrimidine‐based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against…”
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