Search Results - "BARRETT, A. John"

The role of stem cell transplantation for chronic myelogenous leukemia in the 21st century by Barrett, A. John, Ito, Sawa

“…The introduction of tyrosine kinase inhibitors (TKIs), a treatment of chronic myelogenous leukemia (CML), has largely replaced curative strategies based on…”
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Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia by Stringaris, Kate, Sekine, Takuya, Khoder, Ahmad, Alsuliman, Abdullah, Razzaghi, Bonnie, Sargeant, Ruhena, Pavlu, Jiri, Brisley, Gill, de Lavallade, Hugues, Sarvaria, Anushruthi, Marin, David, Mielke, Stephan, Apperley, Jane F, Shpall, Elizabeth J, Barrett, A John, Rezvani, Katayoun

“…The majority of patients with acute myeloid leukemia will relapse, and older patients often fail to achieve remission with induction chemotherapy. We explored…”
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First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer by Barrett, John A, Coleman, R Edward, Goldsmith, Stanley J, Vallabhajosula, Shankar, Petry, Neil A, Cho, Steve, Armor, Thomas, Stubbs, James B, Maresca, Kevin P, Stabin, Michael G, Joyal, John L, Eckelman, William C, Babich, John W

“…This phase 1 study was performed to determine the pharmacokinetics and ability to visualize prostate cancer in bone, soft-tissue, and the prostate gland using…”
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Alemtuzumab Treatment of Intermediate-1 Myelodysplasia Patients Is Associated With Sustained Improvement in Blood Counts and Cytogenetic Remissions by SLOAND, Elaine M, OLNES, Matthew J, YOUNG, Neal S, SHENOY, Aarthie, WEINSTEIN, Barbara, BOSS, Carol, LOELIGER, Kelsey, WU, Colin O, MORE, Kenneth, BARRETT, A. John, SCHEINBERG, Phillip

“…Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and progression to leukemia. Clinical and experimental evidence suggests an…”
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Mitochondrial Metabolism Modulates Differentiation and Teratoma Formation Capacity in Mouse Embryonic Stem Cells by Schieke, Stefan M., Ma, Mingchao, Cao, Liu, McCoy, J. Philip, Liu, Chengyu, Hensel, Nancy F., Barrett, A. John, Boehm, Manfred, Finkel, Toren

“…Relatively little is known regarding the role of mitochondrial metabolism in stem cell biology. Here we demonstrate that mouse embryonic stem cells sorted for…”
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Graft-versus-leukemia reactions in allogeneic chimeras by Kolb, Hans-Jochem, Schmid, Christoph, Barrett, A. John, Schendel, Dolores J.

“…There is a strong graft-versus-leukemia (GVL) effect of allogeneic stem cell transplantation (SCT) due to elimination of tumor cells by alloimmune effector…”
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Acute myeloid leukaemia and the immune system: implications for immunotherapy by Barrett, A. John

“…Summary The recognition of the curative potential of the graft‐versus‐leukaemia effect for patients with acute myeloid leukaemia (AML) undergoing stem cell…”
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Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies by REZVANI, Katayoun, YONG, Agnes S. M, BARRETT, A. John, MIELKE, Stephan, JAFARPOUR, Behnam, SAVANI, Bipin N, LE, Robert Q, ENIAFE, Rhoda, MUSSE, Laura, BOSS, Carol, KURLANDER, Roger

“…We previously showed that vaccination with one dose of PR1 and WT1 peptides induces transient anti-leukemia immunity. We hypothesized that maintenance of a…”
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Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance by Barrett, A John, Sloand, Elaine

“…Accumulating evidence has shown that marrow failure in some patients with myelodysplastic syndrome is associated with autoimmunity, T-cell mediated…”
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Development of 17-Allylamino-17-Demethoxygeldanamycin Hydroquinone Hydrochloride (IPI-504), an Anti-Cancer Agent Directed against Hsp90 by Sydor, Jens R., Normant, Emmanuel, Pien, Christine S., Porter, James R., Ge, Jie, Grenier, Louis, Pak, Roger H., Ali, Janid A., Dembski, Marlene S., Hudak, Jebecka, Patterson, Jon, Penders, Courtney, Pink, Melissa, Read, Margaret A., Sang, Jim, Woodward, Caroline, Zhang, Yilong, Grayzel, David S., Wright, Jim, Barrett, John A., Palombella, Vito J., Adams, Julian, Tong, Jeffrey K.

“…Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective…”
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Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells by Ito, Sawa, Barrett, A. John, Dutra, Amalia, Pak, Evgenia, Miner, Samantha, Keyvanfar, Keyvan, Hensel, Nancy F., Rezvani, Katayoun, Muranski, Pawel, Liu, Paul, Melenhorst, J. Joseph, Larochelle, Andre

“…Mesenchymal stromal cells (MSCs) support the growth and differentiation of normal hematopoietic stem cells (HSCs). Here we studied the ability of MSCs to…”
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Second hematopoietic SCT for leukemia relapsing after myeloablative T cell-depleted transplants does not prolong survival by McIver, Z A, Yin, F, Hughes, T, Battiwalla, M, Ito, S, Koklanaris, E, Haggerty, J, Hensel, N F, John Barrett, A

“…Patients with leukemia relapsing after allogeneic hematopoietic SCT have a dismal prognosis. A second SCT offers a further opportunity for cure, but has a high…”
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British Journal of Haematology celebrates its 200th volume by Barrett, A. John

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Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain by Larochelle, Andre, Gillette, Jennifer M., Desmond, Ronan, Ichwan, Brian, Cantilena, Amy, Cerf, Alexandra, Barrett, A. John, Wayne, Alan S., Lippincott-Schwartz, Jennifer, Dunbar, Cynthia E.

“…Manipulation of hematopoietic stem/progenitor cells (HSPCs) ex vivo is of clinical importance for stem cell expansion and gene therapy applications. However,…”
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Identification of novel microRNA signatures linked to acquired aplastic anemia by Hosokawa, Kohei, Muranski, Pawel, Feng, Xingmin, Keyvanfar, Keyvan, Townsley, Danielle M, Dumitriu, Bogdan, Chen, Jichun, Kajigaya, Sachiko, Taylor, James G, Hourigan, Christopher S, Barrett, A John, Young, Neal S

“…Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated…”
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Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia by Scheinberg, Phillip, Fischer, Steven H., Li, Li, Nunez, Olga, Wu, Colin O., Sloand, Elaine M., Cohen, Jeffrey I., Young, Neal S., John Barrett, A.

“…The natural history of EBV and CMV reactivation and the potential for serious complications following antibody-based immunosuppressive treatment for bone…”
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Quantitative activation suppression assay to evaluate human bone marrow–derived mesenchymal stromal cell potency by Salem, Bahey, Miner, Samantha, Hensel, Nancy F, Battiwalla, Minoo, Keyvanfar, Keyvan, Stroncek, David F, Gee, Adrian P, Hanley, Patrick J, Bollard, Catherine M, Ito, Sawa, Barrett, A. John

“…Abstract Background aims With the increasing use of cell therapies involving immune modulatory cells, there is a need for a simple standardized method to…”
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HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome by Saunthararajah, Yogen, Nakamura, Ryotaro, Nam, Jun-Mo, Robyn, Jamie, Loberiza, Fausto, Maciejewski, Jaroslaw P., Simonis, Toni, Molldrem, Jeffrey, Young, Neal S., Barrett, A. John

“…The extent and importance of autoimmune mechanisms in myelodysplastic syndrome (MDS) and the role of immunosuppression in the treatment of this disease are not…”
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Immunomodulatory Treatment of Myelodysplastic Syndromes: Antithymocyte Globulin, Cyclosporine, and Alemtuzumab by Parikh, Ankur R, Olnes, Matthew J, Barrett, A. John

“…It is now well accepted that a subgroup of patients with myelodysplastic syndromes (MDS) can recover from pancytopenia following immunosuppressive treatment…”
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Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation by Childs, Richard, Chernoff, Allen, Contentin, Nathalie, Bahceci, Erkut, Schrump, David, Leitman, Susan, Read, Elizabeth J, Tisdale, John, Dunbar, Cynthia, Linehan, W. Marston, Young, Neal S, Clave, Emmanuel, Epperson, Diane, Mayo, Virginia, Barrett, A. John

“…Metastatic renal-cell carcinoma has an extremely poor prognosis, with a median survival of less than one year. 1 , 2 Systemic treatment with cytotoxic…”
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