Search Results - "BARRETINA, Jordi"

The landscape of cancer cell line metabolism by Li, Haoxin, Ning, Shaoyang, Ghandi, Mahmoud, Kryukov, Gregory V., Gopal, Shuba, Deik, Amy, Souza, Amanda, Pierce, Kerry, Keskula, Paula, Hernandez, Desiree, Ann, Julie, Shkoza, Dojna, Apfel, Verena, Zou, Yilong, Vazquez, Francisca, Barretina, Jordi, Pagliarini, Raymond A., Galli, Giorgio G., Root, David E., Hahn, William C., Tsherniak, Aviad, Giannakis, Marios, Schreiber, Stuart L., Clish, Clary B., Garraway, Levi A., Sellers, William R.

“…Despite considerable efforts to identify cancer metabolic alterations that might unveil druggable vulnerabilities, systematic characterizations of metabolism…”
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Genomic Medicine Frontier in Human Solid Tumors: Prospects and Challenges by Dienstmann, Rodrigo, Rodon, Jordi, Barretina, Jordi, Tabernero, Josep

“…Recent discoveries of genomic alterations that underlie and promote the malignant phenotype, together with an expanded repertoire of targeted agents, have…”
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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer by Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.

“…Evolved resistance to tyrosine kinase inhibitor (TKI)-targeted therapies remains a major clinical challenge. In epidermal growth factor receptor ( EGFR )…”
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Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes by Ansari-Pour, Naser, Zheng, Yonglan, Yoshimatsu, Toshio F., Sanni, Ayodele, Ajani, Mustapha, Reynier, Jean-Baptiste, Tapinos, Avraam, Pitt, Jason J., Dentro, Stefan, Woodard, Anna, Rajagopal, Padma Sheila, Fitzgerald, Dominic, Gruber, Andreas J., Odetunde, Abayomi, Popoola, Abiodun, Falusi, Adeyinka G., Babalola, Chinedum Peace, Ogundiran, Temidayo, Ibrahim, Nasiru, Barretina, Jordi, Van Loo, Peter, Chen, Mengjie, White, Kevin P., Ojengbede, Oladosu, Obafunwa, John, Huo, Dezheng, Wedge, David C., Olopade, Olufunmilayo I.

“…Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white women of European ancestry. Although…”
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Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib by LACHENMAYER, Anja, ALSINET, Clara, BARRETINA, Jordi, THUNG, Swan, WARD, Stephen C, BRUIX, Jordi, MAZZAFERRO, Vincenzo, SCHWARTZ, Myron, FRIEDMAN, Scott L, LLOVET, Josep M, SAVIC, Radoslav, CABETLOS, Laia, TOFFANIN, Sara, HOSHIDA, Yujin, VILLANUEVA, Augusto, MINGUEZ, Beatriz, NEWELL, Philippa, TSAI, Hung-Wen

“…Hepatocellular carcinoma (HCC) is a heterogeneous cancer with active Wnt signaling. Underlying biologic mechanisms remain unclear and no drug targeting this…”
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Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis by DULAK, Austin M, SCHUMACHER, Steven E, TABERNERO, Josep, BARRETINA, Jordi, ENZINGER, Peter C, CORSO, Giovanni, ROVIELLO, Franco, LIN LIN, BANDLA, Santhoshi, LUKETICH, James D, PENNATHUR, Arjun, MEYERSON, Matthew, LIESHOUT, Jasper Van, OGINO, Shuji, SHIVDASANI, Ramesh A, BEER, David G, GODFREY, Tony E, BEROUKHIM, Rameen, BASS, Adam J, IMAMURA, Yu, FOX, Cameron, SHIM, Byoungyong, RAMOS, Alex H, SAKSENA, Gordon, BACA, Sylvan C, BASELGA, Jose

“…A more detailed understanding of the somatic genetic events that drive gastrointestinal adenocarcinomas is necessary to improve diagnosis and therapy. Using…”
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EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor by Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew J, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei-Ting, Pferdekamper, AnneMarie Culazzo, Lockerman, Elizabeth L, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, DiDonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, McNeill, Matthew, Epple, Robert, Marsilje, Thomas H, Pathan, Nuzhat, Engelman, Jeffrey A, Michellys, Pierre-Yves, McNamara, Peter, Harris, Jennifer, Bender, Steven, Kasibhatla, Shailaja

“…Non-small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to…”
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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia by Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

“…Frank Stegmeier, Levi Garraway and colleagues apply a targeted mass spectrometry approach that measures level of histone modifications and identify a recurrent…”
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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer by Cheung, Hiu Wing, Cowley, Glenn S, Weir, Barbara A, Boehm, Jesse S, Rusin, Scott, Scott, Justine A, East, Alexandra, Ali, Levi D, Lizotte, Patrick H, Wong, Terence C, Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H, Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Ren, Yin, Drapkin, Ronny, Bhatia, Sangeeta N, Mesirov, Jill P, Garraway, Levi A, Meyerson, Matthew, Lander, Eric S, Root, David E, Hahn, William C

“…A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts…”
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Focal gains of VEGFA and molecular classification of hepatocellular carcinoma by Chiang, Derek Y, Villanueva, Augusto, Hoshida, Yujin, Peix, Judit, Newell, Philippa, Minguez, Beatriz, LeBlanc, Amanda C, Donovan, Diana J, Thung, Swan N, Solé, Manel, Tovar, Victoria, Alsinet, Clara, Ramos, Alex H, Barretina, Jordi, Roayaie, Sasan, Schwartz, Myron, Waxman, Samuel, Bruix, Jordi, Mazzaferro, Vincenzo, Ligon, Azra H, Najfeld, Vesna, Friedman, Scott L, Sellers, William R, Meyerson, Matthew, Llovet, Josep M

“…Hepatocellular carcinomas represent the third leading cause of cancer-related deaths worldwide. The vast majority of cases arise in the context of chronic…”
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Biological insights in non-small cell lung cancer by Rosell, Rafael, Jain, Anisha, Codony-Servat, Jordi, Jantus-Lewintre, Eloisa, Morrison, Blake, Ginesta, Jordi Barretina, González-Cao, María

“…Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress. Several tumor types, including non-small cell lung cancer (NSCLC), upregulate…”
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Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma by Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C, Huang, Julie H, Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K, Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M, Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A, Garraway, Levi A, Nelson, Stan F, Liau, Linda, Mischel, Paul S, Cloughesy, Tim F, Meyerson, Matthew, Golub, Todd A, Lander, Eric S, Mellinghoff, Ingo K, Sellers, William R

“…Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics…”
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Nuclear factor I/B is an oncogene in small cell lung cancer by Dooley, Alison L, Winslow, Monte M, Chiang, Derek Y, Banerji, Shantanu, Stransky, Nicolas, Dayton, Talya L, Snyder, Eric L, Senna, Stephanie, Whittaker, Charles A, Bronson, Roderick T, Crowley, Denise, Barretina, Jordi, Garraway, Levi, Meyerson, Matthew, Jacks, Tyler

“…Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC…”
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Integrative analysis of the melanoma transcriptome by Berger, Michael F, Levin, Joshua Z, Vijayendran, Krishna, Sivachenko, Andrey, Adiconis, Xian, Maguire, Jared, Johnson, Laura A, Robinson, James, Verhaak, Roel G, Sougnez, Carrie, Onofrio, Robert C, Ziaugra, Liuda, Cibulskis, Kristian, Laine, Elisabeth, Barretina, Jordi, Winckler, Wendy, Fisher, David E, Getz, Gad, Meyerson, Matthew, Jaffe, David B, Gabriel, Stacey B, Lander, Eric S, Dummer, Reinhard, Gnirke, Andreas, Nusbaum, Chad, Garraway, Levi A

“…Global studies of transcript structure and abundance in cancer cells enable the systematic discovery of aberrations that contribute to carcinogenesis,…”
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E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor by García-Valverde, Alfonso, Rosell, Jordi, Sayols, Sergi, Gómez-Peregrina, David, Pilco-Janeta, Daniel F., Olivares-Rivas, Iván, de Álava, Enrique, Maurel, Joan, Rubió-Casadevall, Jordi, Esteve, Anna, Gut, Marta, Valverde, Claudia, Barretina, Jordi, Carles, Joan, Demetri, George D., Fletcher, Jonathan A., Arribas, Joaquín, Serrano, César

“…KIT/PDGFRA oncogenic tyrosine kinase signaling is the central oncogenic event in most gastrointestinal stromal tumors (GIST), which are human malignant…”
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Functional copy-number alterations in cancer by Taylor, Barry S, Barretina, Jordi, Socci, Nicholas D, Decarolis, Penelope, Ladanyi, Marc, Meyerson, Matthew, Singer, Samuel, Sander, Chris

“…Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about…”
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CDYL Bridges REST and Histone Methyltransferases for Gene Repression and Suppression of Cellular Transformation by Mulligan, Peter, Westbrook, Thomas F., Ottinger, Matthias, Pavlova, Natalya, Chang, Bin, Macia, Eric, Shi, Yu-Jiang, Barretina, Jordi, Liu, Jinsong, Howley, Peter M., Elledge, Stephen J., Shi, Yang

“…The neuronal gene repressor REST/NRSF recruits corepressors, including CoREST, to modify histones and repress transcription. REST also functions as a tumor…”
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Author Correction: Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features by Pitt, Jason J., Riester, Markus, Zheng, Yonglan, Yoshimatsu, Toshio F., Sanni, Ayodele, Oluwasola, Olayiwola, Veloso, Artur, Labrot, Emma, Wang, Shengfeng, Odetunde, Abayomi, Ademola, Adeyinka, Okedere, Babajide, Mahan, Scott, Leary, Rebecca, Macomber, Maura, Ajani, Mustapha, Johnson, Ryan S., Fitzgerald, Dominic, Grundstad, A. Jason, Tuteja, Jigyasa H., Khramtsova, Galina, Zhang, Jing, Sveen, Elisabeth, Hwang, Bryce, Clayton, Wendy, Nkwodimmah, Chibuzor, Famooto, Bisola, Obasi, Esther, Aderoju, Victor, Oludara, Mobolaji, Omodele, Folusho, Akinyele, Odunayo, Adeoye, Adewunmi, Ogundiran, Temidayo, Babalola, Chinedum, MacIsaac, Kenzie, Popoola, Abiodun, Morrissey, Michael P., Chen, Lin S., Wang, Jiebiao, Olopade, Christopher O., Falusi, Adeyinka G., Winckler, Wendy, Haase, Kerstin, Van Loo, Peter, Obafunwa, John, Papoutsakis, Dimitris, Ojengbede, Oladosu, Weber, Barbara, Ibrahim, Nasiru, White, Kevin P., Huo, Dezheng, Olopade, Olufunmilayo I., Barretina, Jordi

“…The original version of this Article contained an error in the author affiliations. The affiliation of Kevin P. White with Tempus Labs, Inc. Chicago, IL, USA…”
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Amplification of chromosomal segment 4q12 in non-small cell lung cancer by Ramos, Alex H., Dutt, Amit, Mermel, Craig, Perner, Sven, Cho, Jeonghee, LaFargue, Christopher J., Johnson, Laura A., Stiedl, Ann-Cathrin, Tanaka, Kumiko E., Bass, Adam, Barretina, Jordi, Weir, Barbara A., Beroukhim, Rameen, Thomas, Roman K., Minna, John D., Chirieac, Lucian R., Lindeman, Neal I., Giordano, Thomas J., Beer, David G., Wagner, Patrick, Wistuba, Ignacio, Rubin, Mark A., Meyerson, Matthew

“…In cancer, proto-oncogenes are often altered by genomic amplification.  Here we report recurrent focal amplifications of chromosomal segment 4q12 overlapping…”
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Identification of ALK gene alterations in urothelial carcinoma by Bellmunt, Joaquim, Selvarajah, Shamini, Rodig, Scott, Salido, Marta, de Muga, Silvia, Costa, Irmgard, Bellosillo, Beatriz, Werner, Lillian, Mullane, Stephanie, Fay, André P, O'Brien, Robert, Barretina, Jordi, Minoche, André E, Signoretti, Sabina, Montagut, Clara, Himmelbauer, Heinz, Berman, David M, Kantoff, Philip, Choueiri, Toni K, Rosenberg, Jonathan E

“…Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers…”
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