Search Results - "BARRES, Ben A"

Microglia and macrophages in brain homeostasis and disease by Li, Qingyun, Barres, Ben A.

“…Key Points Microglia arise solely from yolk sac erythromyeloid precursors under normal conditions, although the precise nature of these precursors is…”
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Reactive Astrocytes: Production, Function, and Therapeutic Potential by Liddelow, Shane A., Barres, Ben A.

“…Astrocytes constitute approximately 30% of the cells in the mammalian central nervous system (CNS). They are integral to brain and spinal-cord physiology and…”
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Emerging roles of astrocytes in neural circuit development by Clarke, Laura E., Barres, Ben A.

“…Key Points Establishment of the correct number and type of synapses is essential for the formation of neural circuits and information processing in the brain…”
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Regulation of synaptic connectivity by glia by Eroglu, Cagla, Barres, Ben A

“…The human brain contains more than 100 trillion (10 14 ) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested…”
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Glia in mammalian development and disease by Zuchero, J Bradley, Barres, Ben A

“…Glia account for more than half of the cells in the mammalian nervous system, and the past few decades have witnessed a flood of studies that detail novel…”
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Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke by Knowland, Daniel, Arac, Ahmet, Sekiguchi, Kohei J., Hsu, Martin, Lutz, Sarah E., Perrino, John, Steinberg, Gary K., Barres, Ben A., Nimmerjahn, Axel, Agalliu, Dritan

“…Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne solutes via tight junctions (TJs) and scarce endocytotic vesicles…”
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Microglia: Scapegoat, Saboteur, or Something Else? by Aguzzi, Adriano, Barres, Ben A., Bennett, Mariko L.

“…Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases…”
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Normal aging induces A1-like astrocyte reactivity by Clarke, Laura E., Liddelow, Shane A., Chakraborty, Chandrani, Münch, Alexandra E., Heiman, Myriam, Barres, Ben A.

“…The decline of cognitive function occurs with aging, but the mechanisms responsible are unknown. Astrocytes instruct the formation, maturation, and elimination…”
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The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease by STEPHAN, Alexander H, BARRES, Ben A, STEVENS, Beth

“…An unexpected role for the classical complement cascade in the elimination of central nervous system (CNS) synapses has recently been discovered. Complement…”
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A Combination of Ontogeny and CNS Environment Establishes Microglial Identity by Bennett, F. Chris, Bennett, Mariko L., Yaqoob, Fazeela, Mulinyawe, Sara B., Grant, Gerald A., Hayden Gephart, Melanie, Plowey, Edward D., Barres, Ben A.

“…Microglia, the brain’s resident macrophages, are dynamic CNS custodians with surprising origins in the extra-embryonic yolk sac. The consequences of their…”
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Do glia drive synaptic and cognitive impairment in disease? by Chung, Won-Suk, Welsh, Christina A, Barres, Ben A, Stevens, Beth

“…There is growing realization that glia actively signal with neurons and influence synaptic development, transmission and plasticity through an array of…”
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner by Schafer, Dorothy P., Lehrman, Emily K., Kautzman, Amanda G., Koyama, Ryuta, Mardinly, Alan R., Yamasaki, Ryo, Ransohoff, Richard M., Greenberg, Michael E., Barres, Ben A., Stevens, Beth

“…Microglia are the resident CNS immune cells and active surveyors of the extracellular environment. While past work has focused on the role of these…”
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Neurotoxic reactive astrocytes induce cell death via saturated lipids by Guttenplan, Kevin A., Weigel, Maya K., Prakash, Priya, Wijewardhane, Prageeth R., Hasel, Philip, Rufen-Blanchette, Uriel, Münch, Alexandra E., Blum, Jacob A., Fine, Jonathan, Neal, Mikaela C., Bruce, Kimberley D., Gitler, Aaron D., Chopra, Gaurav, Liddelow, Shane A., Barres, Ben A.

“…Astrocytes regulate the response of the central nervous system to disease and injury and have been hypothesized to actively kill neurons in neurodegenerative…”
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Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing by Li, Qingyun, Cheng, Zuolin, Zhou, Lu, Darmanis, Spyros, Neff, Norma F., Okamoto, Jennifer, Gulati, Gunsagar, Bennett, Mariko L., Sun, Lu O., Clarke, Laura E., Marschallinger, Julia, Yu, Guoqiang, Quake, Stephen R., Wyss-Coray, Tony, Barres, Ben A.

“…Microglia are increasingly recognized for their major contributions during brain development and neurodegenerative disease. It is currently unknown whether…”
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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model by Guttenplan, Kevin A., Weigel, Maya K., Adler, Drew I., Couthouis, Julien, Liddelow, Shane A., Gitler, Aaron D., Barres, Ben A.

“…Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in…”
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Axon degeneration: molecular mechanisms of a self-destruction pathway by Wang, Jack T, Medress, Zachary A, Barres, Ben A

“…Axon degeneration is a characteristic event in many neurodegenerative conditions including stroke, glaucoma, and motor neuropathies. However, the molecular…”
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Complement and microglia mediate early synapse loss in Alzheimer mouse models by Hong, Soyon, Beja-Glasser, Victoria F., Nfonoyim, Bianca M., Frouin, Arnaud, Li, Shaomin, Ramakrishnan, Saranya, Merry, Katherine M., Shi, Qiaoqiao, Rosenthal, Arnon, Barres, Ben A., Lemere, Cynthia A., Selkoe, Dennis J., Stevens, Beth

“…Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to…”
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Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells by Sloan, Steven A., Darmanis, Spyros, Huber, Nina, Khan, Themasap A., Birey, Fikri, Caneda, Christine, Reimer, Richard, Quake, Stephen R., Barres, Ben A., Paşca, Sergiu P.

“…There is significant need to develop physiologically relevant models for investigating human astrocytes in health and disease. Here, we present an approach for…”
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survey of human brain transcriptome diversity at the single cell level by Darmanis, Spyros, Sloan, Steven A., Zhang, Ye, Enge, Martin, Caneda, Christine, Shuer, Lawrence M., Gephart, Melanie G. Hayden, Barres, Ben A., Quake, Stephen R.

“…Significance The brain comprises an immense number of cells and cellular connections. We describe the first, to our knowledge, single cell whole transcriptome…”
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Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity by Rodda, Lauren B., Lu, Erick, Bennett, Mariko L., Sokol, Caroline L., Wang, Xiaoming, Luther, Sanjiv A., Barres, Ben A., Luster, Andrew D., Ye, Chun Jimmie, Cyster, Jason G.

“…Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the immune response. However, the full diversity of lymph node (LN) SCs…”
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