Search Results - "BARR, Rick"

Beneficial Effects of Trimetazidine in Ex Vivo Working Ischemic Hearts Are Due to a Stimulation of Glucose Oxidation Secondary to Inhibition of Long-Chain 3-Ketoacyl Coenzyme A Thiolase by Lopaschuk, Gary D, Barr, Rick, Thomas, Panakkezhum D, Dyck, Jason R.B

“…ABSTRACT—High rates of fatty acid oxidation in the heart and subsequent inhibition of glucose oxidation contributes to the severity of myocardial ischemia…”
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Malonyl Coenzyme A Decarboxylase Inhibition Protects the Ischemic Heart by Inhibiting Fatty Acid Oxidation and Stimulating Glucose Oxidation by Dyck, Jason R.B, Cheng, Jie-Fei, Stanley, William C, Barr, Rick, Chandler, Margaret P, Brown, Steven, Wallace, David, Arrhenius, Thomas, Harmon, Charles, Yang, Guang, Nadzan, Alex M, Lopaschuk, Gary D

“…Abnormally high rates of fatty acid oxidation and low rates of glucose oxidation are important contributors to the severity of ischemic heart disease. Malonyl…”
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Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts by MCCORMACK, J. G, BARR, R. L, WOLFF, A. A, LOPASCHUK, G. D

“…Ranolazine is a novel antianginal agent that may reduce symptoms without affecting hemodynamics and has shown cardiac antiischemic effects in in vivo and in…”
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Discovery of Potent and Orally Available Malonyl-CoA Decarboxylase Inhibitors as Cardioprotective Agents by Cheng, Jie-Fei, Huang, Yujin, Penuliar, Richard, Nishimoto, Masahiro, Liu, Larry, Arrhenius, Thomas, Yang, Guang, O'Leary, Eoin, Barbosa, Miguel, Barr, Rick, Dyck, Jason R. B, Lopaschuk, Gary D, Nadzan, Alex M

“…Discovery of 5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamides as a new class of malonyl-coenzyme A decarboxylase (MCD)…”
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Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation by Dyck, J R, Barr, A J, Barr, R L, Kolattukudy, P E, Lopaschuk, G D

“…Malonyl-CoA is a potent inhibitor of fatty acid uptake into the mitochondria. Although the synthesis of malonyl-CoA in the heart by acetyl-CoA carboxylase…”
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Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart by Sakamoto, J, Barr, R L, Kavanagh, K M, Lopaschuk, G D

“…Myocardial glucose oxidation is markedly reduced in the uncontrolled diabetic. We determined whether this was due to direct biochemical changes in the heart or…”
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Regulation of myocardial fatty acid oxidation by substrate supply by Longnus, S L, Wambolt, R B, Barr, R L, Lopaschuk, G D, Allard, M F

“…We tested the hypothesis that myocardial substrate supply regulates fatty acid oxidation independent of changes in acetyl-CoA carboxylase (ACC) and…”
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Methodology for measuring in vitro/ex vivo cardiac energy metabolism by Barr, Rick L, Lopaschuk, Gary D

“…The high energy demands of the heart are met primarily by the metabolism of fatty acids and carbohydrates. These energy substrates are efficiently and rapidly…”
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Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism by DYCK, Jason R. B., BERTHIAUME, Luc G., THOMAS, Panakkezhum D., KANTOR, Paul F., BARR, Amy J., BARR, Rick, SINGH, Dyal, HOPKINS, Teresa A., VOILLEY, Nicolas, PRENTKI, Marc, LOPASCHUK, Gary D.

“…In the liver, malonyl-CoA is central to many cellular processes, including both fatty acid biosynthesis and oxidation. Malonyl-CoA decarboxylase (MCD) is…”
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Direct measurement of energy metabolism in the isolated working rat heart by Barr, Rick L., Lopaschuk, Gary D.

“…Fatty acids and carbohydrates are the two main energy substrates used by the heart. Studies involving the regulation of these pathways in the heart have…”
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High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase by Kudo, Naomi, Barr, Amy J., Barr, Rick L., Desai, Snehal, Lopaschuk, Gary D.

“…We determined whether high fatty acid oxidation rates during aerobic reperfusion of ischemic hearts could be explained by a decrease in malonyl-CoA levels,…”
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Synthesis and Structure−Activity Relationship of Small-Molecule Malonyl Coenzyme A Decarboxylase Inhibitors by Cheng, Jie-Fei, Chen, Mi, Wallace, David, Tith, Souvothy, Haramura, Masayuki, Liu, Bin, Mak, Chi Ching, Arrhenius, Thomas, Reily, Sean, Brown, Steven, Thorn, Vicki, Harmon, Charles, Barr, Rick, Dyck, Jason R. B, Lopaschuk, Gary D, Nadzan, Alex M

“…The discovery and structure−activity relationship of first-generation small-molecule malonyl-CoA decarboxylase (MCD; CoA = coenzyme A) inhibitors are reported…”
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Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors by Cheng, Jie-Fei, Mak, Chi Ching, Huang, Yujin, Penuliar, Richard, Nishimoto, Masahiro, Zhang, Lin, Chen, Mi, Wallace, David, Arrhenius, Thomas, Chu, Donald, Yang, Guang, Barbosa, Miguel, Barr, Rick, Dyck, Jason R.B., Lopaschuk, Gary D., Nadzan, Alex M.

“…A series of heteroaryl-substituted bis-trifluoromethyl carbinols 3 were prepared and evaluated as malonyl-CoA decarboxylase inhibitors. Several thiazole…”
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Characterization of rat liver malonyl-CoA decarboxylase and the study of its role in regulating fatty acid metabolism by Dyck, J R, Berthiaume, L G, Thomas, P D, Kantor, P F, Barr, A J, Barr, R, Singh, D, Hopkins, T A, Voilley, N, Prentki, M, Lopaschuk, G D

“…In the liver, malonyl-CoA is central to many cellular processes, including both fatty acid biosynthesis and oxidation. Malonyl-CoA decarboxylase (MCD) is…”
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Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart by Lopaschuk, G D, Witters, L A, Itoi, T, Barr, R, Barr, A

“…Fatty acid oxidation rapidly increases in the rabbit heart following birth. By inhibiting carnitine palmitoyltransferase 1 (CPT1), malonyl-CoA is a potent…”
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Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart by Lopaschuk, G.D, Barr, R.L

“…The isolated working rat heart is a useful experimental model which allows contractile function to be measured in hearts perfused at physiologically relevant…”
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Measurements of fatty acid and carbohydrate metabolism in te isolated working rat heart by Lopaschuk, Gary D, Barr, Rick L

“…The isolated working rat heart is a useful experimental model which allows contractile function to be measured in hearts perfused at physiologically relevant…”
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Oxidant stress and pulmonary hypertension in congenital heart surgery by Dyer, Karrie L., Barr, Rick, Summar, Marshall, Cunningham, Gary, Doyle, Thomas P., Graham, Thomas P., Christman, Brian W.

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Effects of ranolazine on oxidative substrate preference in epitrochlearis muscle by McCormack, J G, Baracos, V E, Barr, R, Lopaschuk, G D

“…Ranolazine is an novel investigational antianginal agent that stimulates glucose oxidation in isolated rat hearts. This study determined its effects on…”
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What happens to the box when big-box stores fold by Barr, Rick

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