Search Results - "BARON, Udo"

DNA methylation controls Foxp3 gene expression by Polansky, Julia K, Kretschmer, Karsten, Freyer, Jennifer, Floess, Stefan, Garbe, Annette, Baron, Udo, Olek, Sven, Hamann, Alf, von Boehmer, Harald, Huehn, Jochen

“…Compelling evidence suggests that Foxp3-expressing CD25⁺CD4⁺ regulatory T cells (Treg) are generated within the thymus as a separate lineage. However,…”
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Epigenetic control of the foxp3 locus in regulatory T cells by Floess, Stefan, Freyer, Jennifer, Siewert, Christiane, Baron, Udo, Olek, Sven, Polansky, Julia, Schlawe, Kerstin, Chang, Hyun-Dong, Bopp, Tobias, Schmitt, Edgar, Klein-Hessling, Stefan, Serfling, Edgar, Hamann, Alf, Huehn, Jochen

“…Compelling evidence suggests that the transcription factor Foxp3 acts as a master switch governing the development and function of CD4(+) regulatory T cells…”
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Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration by Schlundt, Claudia, Reinke, Simon, Geissler, Sven, Bucher, Christian H, Giannini, Carolin, Märdian, Sven, Dahne, Michael, Kleber, Christian, Samans, Björn, Baron, Udo, Duda, Georg N, Volk, Hans-Dieter, Schmidt-Bleek, Katharina

“…There is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration appears to be impaired in case of local…”
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Age dependent differences in the kinetics of γδ T cells after influenza vaccination by Stervbo, Ulrik, Pohlmann, Dominika, Baron, Udo, Bozzetti, Cecilia, Jürchott, Karsten, Mälzer, Julia Nora, Nienen, Mikalai, Olek, Sven, Roch, Toralf, Schulz, Axel Ronald, Warth, Sarah, Neumann, Avidan, Thiel, Andreas, Grützkau, Andreas, Babel, Nina

“…Immunosenescence is a hallmark of the aging immune system and is considered the main cause of a reduced vaccine efficacy in the elderly. Although γδ T cells…”
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Exploring the Sequence Space for Tetracycline-Dependent Transcriptional Activators: Novel Mutations Yield Expanded Range and Sensitivity by Urlinger, Stefanie, Baron, Udo, Thellmann, Marion, Hasan, Mazahir T., Bujard, Hermann, Hillen, Wolfgang

“…Regulatory elements that control tetracycline resistance in Escherichia coli were previously converted into highly specific transcription regulation systems…”
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The Zinc Concentration in the Diet and the Length of the Feeding Period Affect the Methylation Status of the ZIP4 Zinc Transporter Gene in Piglets by Karweina, Diana, Kreuzer-Redmer, Susanne, Müller, Uwe, Franken, Tobias, Pieper, Robert, Baron, Udo, Olek, Sven, Zentek, Jürgen, Brockmann, Gudrun A

“…High doses of zinc oxide are commonly used in weaned pig diets to improve performance and health. Recent reports show that this may also lead to an imbalanced…”
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Epigenetic quantification of tumor-infiltrating T-lymphocytes by Sehouli, Jalid, Loddenkemper, Christoph, Cornu, Tatjana, Schwachula, Tim, Hoffmüller, Ulrich, Grützkau, Andreas, Lohneis, Philipp, Dickhaus, Thorsten, Gröne, Jörn, Kruschewski, Martin, Mustea, Alexander, Turbachova, Ivana, Baron, Udo, Olek, Sven

“…The immune system plays a pivotal role in tumor establishment. However, the role of T-lymphocytes within the tumor microenvironment as major cellular component…”
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Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer by Loddenkemper, Christoph, Hoffmann, Corinna, Stanke, Jonas, Nagorsen, Dirk, Baron, Udo, Olek, Sven, Huehn, Jochen, Ritz, Joerg‐Peter, Stein, Harald, Kaufmann, Andreas M., Schneider, Achim, Cichon, Günter

“…Regulatory (FOXP3+) T cells (Tregs) comprise a subpopulation of CD4+ T cells that suppress autoreactive immune cells, thereby protecting organs and tissues…”
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FOXP3 Epigenetic Signature To Distinguish Between Thymic- and Peripherally-Derived Regulatory T Cells During In Vivo Induction Of Immune Tolerance by Bégin, Philippe, Dr, Baron, Udo, Dr, Olek, Sven, Dr, Bacchetta, Rosa, Dr, Nadeau, Kari C., Dr

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Silencing and un-silencing of tetracycline-controlled genes in neurons by Zhu, Peixin, Aller, M Isabel, Baron, Udo, Cambridge, Sidney, Bausen, Melanie, Herb, Jan, Sawinski, Jürgen, Cetin, Ali, Osten, Pavel, Nelson, Mark L, Kügler, Sebastian, Seeburg, Peter H, Sprengel, Rolf, Hasan, Mazahir T

“…To identify the underlying reason for the controversial performance of tetracycline (Tet)-controlled regulated gene expression in mammalian neurons, we…”
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Regulatory T-cells and associated pathways in metastatic renal cell carcinoma (mRCC) patients undergoing DC-vaccination and cytokine-therapy by Schwarzer, Adrian, Wolf, Benita, Fisher, Jan L, Schwaab, Thomas, Olek, Sven, Baron, Udo, Tomlinson, Craig R, Seigne, John D, Crosby, Nancy A, Gui, Jiang, Hampton, Thomas H, Fadul, Camilo E, Heaney, John A, Ernstoff, Marc S

“…To evaluate CD4(+)CD25(+)FOXP3(+) T regulatory cells (T(REG)) and associated immune-regulatory pathways in peripheral blood lymphocytes (PBL) of metastatic…”
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Co-regulation of two gene activities by tetracycline via a bidirectional promoter by Baron, Udo, Freundlieb, Sabine, Gossen, Manfred, Bujard, Hermann

“…Recently, we have described a regulatory system that allows the stringent control of individual gene activities in higher eukaryotic cell lines, in plants and…”
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DNA Methylation Analysis as a Tool for Cell Typing by Baron, Udo, Turbachova, Ivana, Hellwag, Alexander, Eckhardt, Florian, Berlin, Kurt, Hoffmüller, Ulrich, Gardina, Paul, Olek, Sven

“…Cell therapeutic approaches currently lack definitive quality control measures which guarantee safety in clinical applications and create consistent standards…”
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Generation of Conditional Mutants in Higher Eukaryotes by Switching between the Expression of Two Genes by Baron, Udo, Schnappinger, Dirk, Helbl, Vera, Gossen, Manfred, Hillen, Wolfgang, Bujard, Hermann

“…A regulatory system for the in-depth study of gene functions in higher eukaryotic cells has been developed. It is based on the tetracycline-controlled…”
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Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes by McClymont, Stephanie A, Putnam, Amy L, Lee, Michael R, Esensten, Jonathan H, Liu, Weihong, Hulme, Maigan A, Hoffmüller, Ulrich, Baron, Udo, Olek, Sven, Bluestone, Jeffrey A, Brusko, Todd M

“…Regulatory T cells (Tregs) constitute an attractive therapeutic target given their essential role in controlling autoimmunity. However, recent animal studies…”
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Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus by Toker, Aras, Engelbert, Dirk, Garg, Garima, Polansky, Julia K, Floess, Stefan, Miyao, Takahisa, Baron, Udo, Düber, Sandra, Geffers, Robert, Giehr, Pascal, Schallenberg, Sonja, Kretschmer, Karsten, Olek, Sven, Walter, Jörn, Weiss, Siegfried, Hori, Shohei, Hamann, Alf, Huehn, Jochen

“…Stable expression of Foxp3 in regulatory T cells (Tregs) depends on DNA demethylation at the Treg-specific demethylated region (TSDR), a conserved, CpG-rich…”
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DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3⁺ conventional T cells by Baron, Udo, Floess, Stefan, Wieczorek, Georg, Baumann, Katrin, Grützkau, Andreas, Dong, Jun, Thiel, Andreas, Boeld, Tina J, Hoffmann, Petra, Edinger, Matthias, Türbachova, Ivana, Hamann, Alf, Olek, Sven, Huehn, Jochen

“…The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg). Their number and functioning appears to be crucial in the…”
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FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency by Peiseler, Moritz, Sebode, Marcial, Franke, Björn, Wortmann, Frederike, Schwinge, Dorothee, Quaas, Alexander, Baron, Udo, Olek, Sven, Wiegard, Christiane, Lohse, Ansgar W, Weiler-Normann, Christina, Schramm, Christoph, Herkel, Johannes

“…Background & Aims The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional…”
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Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue by WIECZOREK, Georg, ASEMISSEN, Anne, HAMANN, Alf, LODDENKEMPER, Christoph, STEIN, Harald, DIETER VOLK, Hans, HOFFMÜLLER, Ulrich, GRÜTZKAU, Andreas, MUSTEA, Alexander, HUEHN, Jochen, SCHEIBENBOGEN, Carmen, OLEK, Sven, MODEL, Fabian, TURBACHOVA, Ivana, FLOES, Stefan, LIEBENBERG, Volker, BARON, Udo, STAUCH, Diana, KOTSCH, Katja, PRATSCHKE, Johann

“…Regulatory T-cells (Treg) have been the focus of immunologic research due to their role in establishing tolerance for harmless antigens versus allowing immune…”
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Abstract 1739: Detection of regulatory T cells, a comparison of flow cytometry and epigenetic qPCR immunophenotyping using healthy donor and oncology patient whole blood by Baron, Udo, Lozza, Laura, Bisconte, Angelina, Raschke, Eva, Phippard, Deborah, Olek, Sven

“…Abstract Human regulatory T cells (Tregs) are part of the adaptive immune response and play a pivotal role in suppressing both the immune and anti-tumor…”
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