Search Results - "BARNIDGE, David R"

The utility of MASS‐FIX to detect and monitor monoclonal proteins in the clinic by Milani, Paolo, Murray, David L., Barnidge, David R., Kohlhagen, Mindy C., Mills, John R., Merlini, Giampaolo, Dasari, Surendra, Dispenzieri, Angela

“…The detection and quantification of monoclonal‐proteins (M‐proteins) are necessary for the diagnosis and evaluation of response in plasma cell dyscrasias…”
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Mass Spectrometry Approaches for Identification and Quantitation of Therapeutic Monoclonal Antibodies in the Clinical Laboratory by Ladwig, Paula M, Barnidge, David R, Willrich, Maria A V

“…Therapeutic monoclonal antibodies (MAbs) are an important class of drugs used to treat diseases ranging from autoimmune disorders to B cell lymphomas to other…”
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Analysis of Monoclonal Antibodies in Human Serum as a Model for Clinical Monoclonal Gammopathy by Use of 21 Tesla FT-ICR Top-Down and Middle-Down MS/MS by He, Lidong, Anderson, Lissa C., Barnidge, David R., Murray, David L., Hendrickson, Christopher L., Marshall, Alan G.

“…With the rapid growth of therapeutic monoclonal antibodies (mAbs), stringent quality control is needed to ensure clinical safety and efficacy. Monoclonal…”
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Laboratory testing in monoclonal gammopathy of renal significance (MGRS) by Leung, Nelson, Barnidge, David R, Hutchison, Colin A

“…Recently, monoclonal gammopathy of renal significance (MGRS) reclassified all monoclonal (M) gammopathies that are associated with the development of a kidney…”
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Quantitation of infliximab using clonotypic peptides and selective reaction monitoring by LC–MS/MS by Willrich, Maria Alice V., Murray, David L., Barnidge, David R., Ladwig, Paula M., Snyder, Melissa R.

“…Although therapeutic concentrations of infliximab (chimeric IgG1 kappa) are associated with improved clinical prognosis, clinical laboratory methods for…”
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Quantification of the IgG2/4 kappa Monoclonal Therapeutic Eculizumab from Serum Using Isotype Specific Affinity Purification and Microflow LC-ESI-Q-TOF Mass Spectrometry by Ladwig, Paula M., Barnidge, David R., Willrich, Maria A.V.

“…As therapeutic monoclonal antibodies (mAbs) become more humanized, traditional tryptic peptide approaches used to measure biologics in serum become more…”
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Quantification of serum IgG subclasses by use of subclass-specific tryptic peptides and liquid chromatography--tandem mass spectrometry by Ladwig, Paula M, Barnidge, David R, Snyder, Melissa R, Katzmann, Jerry A, Murray, David L

“…Measurement of IgG subclasses is a useful tool for investigation of humoral immune deficiency in the presence of total IgG within reference intervals and…”
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Analysis of monoclonal immunoglobulins from bone marrow plasma cells using immunopurification and LC-MS by Barnidge, David R., Dispenzieri, Angela, Jevremovic, Dragan, Murray, David L.

“…•Procedure for isolating and characterizing M−proteins within the malignant plasma cells in the bone marrow.•Potential alternative to flow cytometry.•Changes…”
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Selected Reaction Monitoring-Mass Spectrometric Immunoassay Responsive to Parathyroid Hormone and Related Variants by Lopez, Mary F, Rezai, Taha, Sarracino, David A, Prakash, Amol, Krastins, Bryan, Athanas, Michael, Singh, Ravinder J, Barnidge, David R, Oran, Paul, Borges, Chad, Nelson, Randall W

“…Parathyroid hormone (PTH) assays able to distinguish between full-length PTH (PTH1-84) and N-terminally truncated PTH (PTH7-84) are of increasing significance…”
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Washing mineral oil reduces contaminants and embryotoxicity by Morbeck, Dean E., Ph.D, Khan, Zaraq, M.B.B.S, Barnidge, David R., Ph.D, Walker, David L., M.S

“…Objective To determine if washing improves the quality of mineral oil used for embryo culture. Design A 2 × 3 factorial experimental study. Setting University…”
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Absolute Quantification of the Model Biomarker Prostate-Specific Antigen in Serum by LC−MS/MS Using Protein Cleavage and Isotope Dilution Mass Spectrometry by Barnidge, David R, Goodmanson, Marcia K, Klee, George G, Muddiman, David C

“…Protein cleavage-isotope dilution mass spectrometry (PC-IDMS) can be used to quantify proteins, with an isotope-labeled analogue of the peptide fragment used…”
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Using Mass Spectrometry to Quantify Rituximab and Perform Individualized Immunoglobulin Phenotyping in ANCA-Associated Vasculitis by Mills, John R, Cornec, Divi, Dasari, Surendra, Ladwig, Paula M, Hummel, Amber M, Cheu, Melissa, Murray, David L, Willrich, Maria A, Snyder, Melissa R, Hoffman, Gary S, Kallenberg, Cees G. M, Langford, Carol A, Merkel, Peter A, Monach, Paul A, Seo, Philip, Spiera, Robert F, St. Clair, E. William, Stone, John H, Specks, Ulrich, Barnidge, David R

“…Therapeutic monoclonal immunoglobulins (mAbs) are used to treat patients with a wide range of disorders including autoimmune diseases. As pharmaceutical…”
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LC-MS/MS quantification of Zn-α2 glycoprotein : A potential serum biomarker for prostate cancer by BONDAR, Olga P, BARNIDGE, David R, KLEE, Eric W, DAVIS, Brian J, KLEE, George G

“…Abstract Background: Zn-α2 glycoprotein (ZAG) is a relatively abundant glycoprotein that has potential as a biomarker for prostate cancer. We present a…”
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Absolute Quantification of the G Protein-Coupled Receptor Rhodopsin by LC/MS/MS Using Proteolysis Product Peptides and Synthetic Peptide Standards by Barnidge, David R, Dratz, Edward A, Martin, Therese, Bonilla, Leo E, Moran, Liam B, Lindall, Arnold

“…Methods for the absolute quantification of a membrane protein are described using isotopically labeled or unlabeled synthetic peptides as standards. Synthetic…”
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Detecting monoclonal immunoglobulins in human serum using mass spectrometry by Mills, John R., Barnidge, David R., Murray, David L.

“…•Mass spectrometry is a viable approach to detect monoclonal proteins in human serum.•miRAMM provides superior sensitivity compared with current clinical…”
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Comprehensive Assessment of M-Proteins Using Nanobody Enrichment Coupled to MALDI-TOF Mass Spectrometry by Mills, John R, Kohlhagen, Mindy C, Dasari, Surendra, Vanderboom, Patrick M, Kyle, Robert A, Katzmann, Jerry A, Willrich, Maria A V, Barnidge, David R, Dispenzieri, Angela, Murray, David L

“…Electrophoretic separation of serum and urine proteins has played a central role in diagnosing and monitoring plasma cell disorders. Despite limitations in…”
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Using Mass Spectrometry to Monitor Monoclonal Immunoglobulins in Patients with a Monoclonal Gammopathy by Barnidge, David R, Dasari, Surendra, Botz, Chad M, Murray, Danelle H, Snyder, Melissa R, Katzmann, Jerry A, Dispenzieri, Angela, Murray, David L

“…A monoclonal gammopathy is defined by the detection a monoclonal immunoglobulin (M-protein). In clinical practice, the M-protein is detected by protein gel…”
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Classification of Plasma Cell Disorders by 21 Tesla Fourier Transform Ion Cyclotron Resonance Top-Down and Middle-Down MS/MS Analysis of Monoclonal Immunoglobulin Light Chains in Human Serum by He, Lidong, Anderson, Lissa C, Barnidge, David R, Murray, David L, Dasari, Surendra, Dispenzieri, Angela, Hendrickson, Christopher L, Marshall, Alan G

“…The current five-year survival rate for systemic AL amyloidosis or multiple myeloma is ∼51%, indicating the urgent need for better diagnosis methods and…”
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Clonotypic Light Chain Peptides Identified for Monitoring Minimal Residual Disease in Multiple Myeloma without Bone Marrow Aspiration by Bergen, 3rd, H Robert, Dasari, Surendra, Dispenzieri, Angela, Mills, John R, Ramirez-Alvarado, Marina, Tschumper, Renee C, Jelinek, Diane F, Barnidge, David R, Murray, David L

“…Analytically sensitive techniques for measuring minimal residual disease (MRD) in multiple myeloma (MM) currently require invasive and costly bone marrow…”
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Monitoring free light chains in serum using mass spectrometry by Barnidge, David R, Dispenzieri, Angela, Merlini, Giampaolo, Katzmann, Jerry A, Murray, David L

“…Serum immunoglobulin free light chains (FLC) are secreted into circulation by plasma cells as a by-product of immunoglobulin production. In a healthy…”
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