Search Results - "BARNETT, Gillian C"

Randomized Controlled Trial of Intensity-Modulated Radiotherapy for Early Breast Cancer: 5-Year Results Confirm Superior Overall Cosmesis by MUKESH, Mukesh B, BARNETT, Gillian C, WISHART, Gordon C, COLES, Charlotte E, WILKINSON, Jennifer S, MOODY, Anne M, WILSON, Charles, DORLING, Leila, CHAN WAH HAK, Charleen, WENDI QIAN, TWYMAN, Nicola, BURNET, Neil G

“…There are few randomized controlled trial data to confirm that improved homogeneity with simple intensity-modulated radiotherapy (IMRT) decreases late breast…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Genetics and genomics of radiotherapy toxicity: towards prediction by West, Catharine M, Barnett, Gillian C

“…Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority…”
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A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1 by Fachal, Laura, Gómez-Caamaño, Antonio, Barnett, Gillian C, Peleteiro, Paula, Carballo, Ana M, Calvo-Crespo, Patricia, Kerns, Sarah L, Sánchez-García, Manuel, Lobato-Busto, Ramón, Dorling, Leila, Elliott, Rebecca M, Dearnaley, David P, Sydes, Matthew R, Hall, Emma, Burnet, Neil G, Carracedo, Ángel, Rosenstein, Barry S, West, Catharine M L, Dunning, Alison M, Vega, Ana

“…Ana Vega and colleagues report the results of a three-stage genome-wide association study of radiotherapy toxicity following treatment for prostate cancer…”
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Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study by Barnett, Gillian C, Dr, Coles, Charlotte E, PhD, Elliott, Rebecca M, MRes, Baynes, Caroline, Luccarini, Craig, BSc, Conroy, Don, Wilkinson, Jennifer S, BSc, Tyrer, Jonathan, PhD, Misra, Vivek, MB BS, Platte, Radka, BSc, Gulliford, Sarah L, PhD, Sydes, Matthew R, MSc, Hall, Emma, PhD, Bentzen, Søren M, Prof, Dearnaley, David P, Prof, Burnet, Neil G, PhD, Pharoah, Paul DP, PhD, Dunning, Alison M, PhD, West, Catharine ML, Prof

“…Summary Background Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few…”
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Randomized Controlled Trial of Forward-Planned Intensity Modulated Radiotherapy for Early Breast Cancer: Interim Results at 2 Years by Barnett, Gillian C., B.M., B.Ch, Wilkinson, Jennifer S., B.Sc, Moody, Anne M., M.B., B.Chir, Wilson, Charles B., M.D, Twyman, Nicola, M.Sc, Wishart, Gordon C., M.D, Burnet, Neil G., M.D, Coles, Charlotte E., Ph.D

“…Purpose This single-center randomized trial was designed to investigate whether intensity-modulated radiotherapy (IMRT) reduces late toxicity in patients with…”
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Risk Factors for the Incidence of Breast Cancer: Do They Affect Survival From the Disease? by BARNETT, Gillian C, SHAH, Mitul, REDMAN, Karen, EASTON, Douglas F, PONDER, Bruce A. J, PHAROAH, Paul D. P

“…Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis. Data from 4,560 women with invasive breast cancer who had…”
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STROGAR – STrengthening the Reporting Of Genetic Association studies in Radiogenomics by Kerns, Sarah L, Ruysscher, Dirk de, Andreassen, Christian N, Azria, David, Barnett, Gillian C, Chang-Claude, Jenny, Davidson, Susan, Deasy, Joseph O, Dunning, Alison M, Ostrer, Harry, Rosenstein, Barry S, West, Catharine M.L, Bentzen, Søren M

“…Abstract Despite publication of numerous radiogenomics studies to date, positive single nucleotide polymorphism (SNP) associations have rarely been reproduced…”
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Radiogenomics: the search for genetic predictors of radiotherapy response by Kerns, Sarah L, West, Catharine M L, Andreassen, C Nicolaj, Barnett, Gillian C, Bentzen, Søren M, Burnet, Neil G, Dekker, Andre, De Ruysscher, Dirk, Dunning, Alison, Parliament, Matthew, Talbot, Chris, Vega, Ana, Rosenstein, Barry S

“…'Radiogenomics' is the study of genetic variation associated with response to radiotherapy. Radiogenomics aims to uncover the genes and biologic pathways…”
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The impact of neuroradiology collaboration in head and neck cancer radiotherapy peer review by Gatfield, Elinor R, Benson, Richard J, Jadon, Rashmi, Das, Tilak, Barnett, Gillian C

“…To quantify the impact of neuroradiologist presence on head and neck cancer (HNC) radiotherapy peer review (PR) changes. Prospective data were collected from…”
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Democratising artificial intelligence in healthcare: community-driven approaches for ethical solutions by Welsh, Ceilidh, Román García, Susana, Barnett, Gillian C., Jena, Raj

“…The rapid advancement and widespread adoption of artificial intelligence (AI) has ushered in a new era of possibilities in healthcare, ranging from clinical…”
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Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord by Noble, David J., Yeap, Ping-Lin, Seah, Shannon Y.K., Harrison, Karl, Shelley, Leila E.A., Romanchikova, Marina, Bates, Amy M., Zheng, Yaolin, Barnett, Gillian C., Benson, Richard J., Jefferies, Sarah J., Thomas, Simon J., Jena, Raj, Burnet, Neil G.

“…•A cohort of 133 head & neck cancer patients treated with TomoTherapy was examined.•Differences between planned and delivered maximum spinal cord dose were…”
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No Association Between Polygenic Risk Scores for Cancer and Development of Radiation Therapy Toxicity by Barnett, Gillian C., Kerns, Sarah L., Dorling, Leila, Fachal, Laura, Aguado-Barrera, Miguel E., Martínez-Calvo, Laura, Jandu, Harkeran K., Welsh, Ceilidh, Tyrer, Jonathan, Coles, Charlotte E., Haviland, Joanne S., Parker, Christopher, Gómez-Caamaño, Antonio, Calvo-Crespo, Patricia, Sosa-Fajardo, Paloma, Burnet, Neil G., Summersgill, Holly, Webb, Adam, De Ruysscher, Dirk, Seibold, Petra, Chang-Claude, Jenny, Talbot, Christopher J., Rattay, Tim, Parliament, Matthew, De Ruyck, Kim, Rosenstein, Barry S., Pharoah, Paul D.P., Dunning, Alison M., Vega, Ana, West, Catharine M.L.

“…Our aim was to test whether updated polygenic risk scores (PRS) for susceptibility to cancer affect risk of radiation therapy toxicity. Analyses included 9,717…”
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Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: Results from the Cambridge Breast IMRT trial by Mukesh, Mukesh B, Qian, Wendi, Wilkinson, Jennifer S, Dorling, Leila, Barnett, Gillian C, Moody, Anne M, Wilson, Charles, Twyman, Nicola, Burnet, Neil G, Wishart, Gordon C, Coles, Charlotte E

“…Abstract Background The use of intensity-modulated radiotherapy (IMRT) in breast cancer reduces clinician-assessed breast tissue toxicity including fibrosis,…”
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Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity by Dorling, Leila, Barnett, Gillian C, Michailidou, Kyriaki, Coles, Charlotte E, Burnet, Neil G, Yarnold, John, Elliott, Rebecca M, Dunning, Alison M, Pharoah, Paul D P, West, Catharine M

“…It has been hypothesized that increased predisposition to breast cancer may correlate with radiosensitivity, and thus increased risk of toxicity following…”
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A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: Baseline characteristics and dosimetry results by Barnett, Gillian C, Wilkinson, Jennifer, Moody, Anne M, Wilson, Charles B, Sharma, Ravi, Klager, Sabine, Hoole, Andrew C.F, Twyman, Nicola, Burnet, Neil G, Coles, Charlotte E

“…Abstract Background and purpose This large trial was designed to investigate whether correction of dose inhomogeneities using intensity-modulated radiotherapy…”
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Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer by Kerns, Sarah L., Dorling, Leila, Fachal, Laura, Bentzen, Søren, Pharoah, Paul D.P., Barnes, Daniel R., Gómez-Caamaño, Antonio, Carballo, Ana M., Dearnaley, David P., Peleteiro, Paula, Gulliford, Sarah L., Hall, Emma, Michailidou, Kyriaki, Carracedo, Ángel, Sia, Michael, Stock, Richard, Stone, Nelson N., Sydes, Matthew R., Tyrer, Jonathan P., Ahmed, Shahana, Parliament, Matthew, Ostrer, Harry, Rosenstein, Barry S., Vega, Ana, Burnet, Neil G., Dunning, Alison M., Barnett, Gillian C., West, Catharine M.L.

“…Nearly 50% of cancer patients undergo radiotherapy. Late radiotherapy toxicity affects quality-of-life in long-term cancer survivors and risk of side-effects…”
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Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity by Barnett, Gillian C, Elliott, Rebecca M, Alsner, Jan, Andreassen, Christian N, Abdelhay, Osama, Burnet, Neil G, Chang-Claude, Jenny, Coles, Charlotte E, Gutiérrez-Enríquez, Sara, Fuentes-Raspall, Maria J, Alonso-Muñoz, Maria C, Kerns, Sarah, Raabe, Annette, Symonds, R. Paul, Seibold, Petra, Talbot, Chris J, Wenz, Frederik, Wilkinson, Jennifer, Yarnold, John, Dunning, Alison M, Rosenstein, Barry S, West, Catharine M.L, Bentzen, Søren M

“…Abstract Background and purpose Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in…”
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No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: Results from the RAPPER study by Barnett, Gillian C, Coles, Charlotte E, Burnet, Neil G, Pharoah, Paul D.P, Wilkinson, Jennifer, West, Catharine M.L, Elliott, Rebecca M, Baynes, Caroline, Dunning, Alison M

“…Abstract Background and purpose Several small studies have reported associations between TGFB1 single nucleotide polymorphisms (SNPs), considered to increase…”
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Standardized Total Average Toxicity Score: A Scale- and Grade-Independent Measure of Late Radiotherapy Toxicity to Facilitate Pooling of Data From Different Studies by Barnett, Gillian C., B.M., B.Ch, West, Catharine M.L., Ph.D, Coles, Charlotte E., Ph.D, Pharoah, Paul D.P., Ph.D, Talbot, Christopher J., Ph.D, Elliott, Rebecca M., M.Res, Tanteles, George A., M.D, Symonds, R. Paul, M.D, Wilkinson, Jennifer S., B.Sc, Dunning, Alison M., Ph.D, Burnet, Neil G., M.D, Bentzen, Søren M., Ph.D

“…Purpose The search for clinical and biologic biomarkers associated with late radiotherapy toxicity is hindered by the use of multiple and different endpoints…”
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