Search Results - "BARNES, S. Whitney"

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis by Tahlan, Kapil, Wilson, Regina, Kastrinsky, David B, Arora, Kriti, Nair, Vinod, Fischer, Elizabeth, Barnes, S. Whitney, Walker, John R, Alland, David, Barry, Clifton E., III, Boshoff, Helena I

“…SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we…”
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Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery by Meister, Stephan, Plouffe, David M., Kuhen, Kelli L., Bonamy, Ghislain M. C., Wu, Tao, Barnes, S. Whitney, Bopp, Selina E., Borboa, Rachel, Bright, A. Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V., Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus C. S., McNamara, Case W., Fidock, David A., Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J., Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G., Tuntland, Tove, Walker, John R., Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T., Winzeler, Elizabeth A.

“…Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against…”
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Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells by Ting, Pamela Y., Parker, Albert E., Lee, J. Scott, Trussell, Chris, Sharif, Orzala, Luna, Fabio, Federe, Glenn, Barnes, S. Whitney, Walker, John R., Vance, Julie, Gao, Mu-Yun, Klock, Heath E., Clarkson, Scott, Russ, Carsten, Miraglia, Loren J., Cooke, Michael P., Boitano, Anthony E., McNamara, Peter, Lamb, John, Schmedt, Christian, Snead, Jennifer L.

“…CRISPR–Cas9 screening allows genome-wide interrogation of gene function. Currently, to achieve the high and uniform Cas9 expression desirable for screening,…”
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A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening by Beri, Pranjali, Woo, Young Jae, Schierenbeck, Katie, Chen, Kaisheng, Barnes, S Whitney, Ross, Olivia, Krutil, Douglas, Quackenbush, Doug, Fang, Bin, Walker, John, Barnes, William, Toyama, Erin Quan

“…Cigarette smoking (CS) is the leading cause of COPD, and identifying the pathways that are driving pathogenesis in the airway due to CS exposure can aid in the…”
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In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin by Leeds, Jennifer A, Sachdeva, Meena, Mullin, Steve, Barnes, S Whitney, Ruzin, Alexey

“…Current treatments for Clostridium difficile infection include vancomycin, metronidazole and fidaxomicin. LFF571 is an experimental agent undergoing evaluation…”
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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction by Ting, Pamela Y, Borikar, Sneha, Kerrigan, John Ryan, Thomsen, Noel M, Aghania, Eamon, Hinman, Amelia E, Reyes, Alejandro, Pizzato, Nicolas, Fodor, Barna D, Wu, Fabian, Belew, Muluken S, Mao, Xiaohong, Wang, Jian, Chitnis, Shripad, Niu, Wei, Hachey, Amanda, Cobb, Jennifer S, Savage, Nikolas A, Burke, Ashley, Paulk, Joshiawa, Dovala, Dustin, Lin, James, Clifton, Matthew C, Ornelas, Elizabeth, Ma, Xiaolei, Ware, Nathaniel F, Sanchez, Carina C, Taraszka, John, Terranova, Remi, Knehr, Judith, Altorfer, Marc, Barnes, S Whitney, Beckwith, Rohan E J, Solomon, Jonathan M, Dales, Natalie A, Patterson, Andrew W, Wagner, Jürgen, Bouwmeester, Tewis, Dranoff, Glenn, Stevenson, Susan C, Bradner, James E

“…Sickle cell disease (SCD) is a prevalent, life-threatening condition attributable to a heritable mutation in β-hemoglobin. Therapeutic induction of fetal…”
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"3D, human renal proximal tubule (RPTEC-TERT1) organoids 'tubuloids' for translatable evaluation of nephrotoxins in high-throughput" by Vidal Yucha, Sarah E, Quackenbush, Doug, Chu, Tiffany, Lo, Frederick, Sutherland, Jeffrey J, Kuzu, Guray, Roberts, Christopher, Luna, Fabio, Barnes, S Whitney, Walker, John, Kuss, Pia

“…The importance of human cell-based in vitro tools to drug development that are robust, accurate, and predictive cannot be understated. There has been…”
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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy by Pethe, Kevin, Sequeira, Patricia C, Agarwalla, Sanjay, Rhee, Kyu, Kuhen, Kelli, Phong, Wai Yee, Patel, Viral, Beer, David, Walker, John R, Duraiswamy, Jeyaraj, Jiricek, Jan, Keller, Thomas H, Chatterjee, Arnab, Tan, Mai Ping, Ujjini, Manjunatha, Rao, Srinivasa P.S, Camacho, Luis, Bifani, Pablo, Mak, Puiying A, Ma, Ida, Barnes, S. Whitney, Chen, Zhong, Plouffe, David, Thayalan, Pamela, Ng, Seow Hwee, Au, Melvin, Lee, Boon Heng, Tan, Bee Huat, Ravindran, Sindhu, Nanjundappa, Mahesh, Lin, Xiuhua, Goh, Anne, Lakshminarayana, Suresh B, Shoen, Carolyn, Cynamon, Michael, Kreiswirth, Barry, Dartois, Veronique, Peters, Eric C, Glynne, Richard, Brenner, Sydney, Dick, Thomas

“…Candidate antibacterials are usually identified on the basis of their in vitro activity. However, the apparent inhibitory activity of new leads can be…”
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Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms by Jones, Adriana K, Caughlan, Ruth E, Woods, Angela L, Uehara, Kyoko, Xie, Lili, Barnes, S Whitney, Walker, John R, Thompson, Katherine V, Ranjitkar, Srijan, Lee, Patrick S, Dean, Charles R

“…Upregulated expression of efflux pumps, target mutations, LpxC protein overexpression, and mutations in were previously shown to mediate single-step resistance…”
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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease by Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek

“…Unbiased phenotypic screens enable identification of small molecules that inhibit pathogen growth by unanticipated mechanisms. These small molecules can be…”
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Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes by Dharia, Neekesh V., Bright, A. Taylor, Westenberger, Scott J., Barnes, S. Whitney, Batalov, Serge, Kuhen, Kelli, Borboa, Rachel, Federe, Glenn C., McClean, Colleen M., Vinetz, Joseph M., Neyra, Victor, Llanos-Cuentas, Alejandro, Barnwell, John W., Walker, John R., Winzeler, Elizabeth A., James, Anthony A.

“…Plasmodium vivax causes 25-40% of malaria cases worldwide, yet research on this human malaria parasite has been neglected. Nevertheless, the recent publication…”
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Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies by Daley, Stephen R, Coakley, Kristen M, Hu, Daniel Y, Randall, Katrina L, Jenne, Craig N, Limnander, Andre, Myers, Darienne R, Polakos, Noelle K, Enders, Anselm, Roots, Carla, Balakishnan, Bhavani, Miosge, Lisa A, Sjollema, Geoff, Bertram, Edward M, Field, Matthew A, Shao, Yunli, Andrews, T Daniel, Whittle, Belinda, Barnes, S Whitney, Walker, John R, Cyster, Jason G, Goodnow, Christopher C, Roose, Jeroen P

“…Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1(Anaef), with an ENU-mutated EF hand in…”
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Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression by Ranjitkar, Srijan, Jones, Adriana K, Mostafavi, Mina, Zwirko, Zachary, Iartchouk, Oleg, Barnes, S Whitney, Walker, John R, Willis, Thomas W, Lee, Patrick S, Dean, Charles R

“…Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance…”
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Genome-Wide Single-Nucleotide Polymorphism Analysis Defines Haplotype Patterns in Mouse by Wiltshire, Tim, Pletcher, Mathew T., Batalov, Serge, Barnes, S. Whitney, Tarantino, Lisa M., Cooke, Michael P., Wu, Hua, Smylie, Kevin, Santrosyan, Andrey, Copeland, Neal G., Jenkins, Nancy A., Kalush, Francis, Mural, Richard J., Glynne, Richard J., Kay, Steve A., Adams, Mark D., Fletcher, Colin F.

“…The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated…”
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Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis by VILCHEZE, Catherine, AV-GAY, Yossef, WHITNEY BARNES, S, LARSEN, Michelle H, WALKER, John R, GLYNNE, Richard J, JACOBS, William R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A high throughput cell stretch device for investigating mechanobiology in vitro by Pratt, Stephen J. P., Plunkett, Christopher M., Kuzu, Guray, Trinh, Ton, Barbara, Joshua, Choconta, Paula, Quackenbush, Doug, Huynh, Truc, Smith, Anders, Barnes, S. Whitney, New, Joel, Pierce, James, Walker, John R., Mainquist, James, King, Frederick J., Elliott, Jimmy, Hammack, Scott, Decker, Rebekah S.

“…Mechanobiology is a rapidly advancing field, with growing evidence that mechanical signaling plays key roles in health and disease. To accelerate…”
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A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma by Beri, Pranjali, Plunkett, Christopher, Barbara, Joshua, Shih, Chien-Cheng, Barnes, S. Whitney, Ross, Olivia, Choconta, Paula, Trinh, Ton, Gomez, Datzael, Litvin, Bella, Walker, John, Qiu, Minhua, Hammack, Scott, Toyama, Erin Quan

“…Asthma is often characterized by tissue-level mechanical phenotypes that include remodeling of the airway and an increase in airway tightening, driven by the…”
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Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse by Pletcher, Mathew T, McClurg, Philip, Batalov, Serge, Su, Andrew I, Barnes, S Whitney, Lagler, Erica, Korstanje, Ron, Wang, Xiaosong, Nusskern, Deborah, Bogue, Molly A, Mural, Richard J, Paigen, Beverly, Wiltshire, Tim

“…Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the…”
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Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa by CAUGHLAN, Ruth E, JONES, Adriana K, DEAN, Charles R, DELUCIA, Angela M, WOODS, Angela L, LILI XIE, BING MA, BARNES, S. Whitney, WALKER, John R, SPRAGUE, Elizabeth R, XIA YANG

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of elongation factor G as the conserved cellular target of argyrin B by Nyfeler, Beat, Hoepfner, Dominic, Palestrant, Deborah, Kirby, Christina A, Whitehead, Lewis, Yu, Robert, Deng, Gejing, Caughlan, Ruth E, Woods, Angela L, Jones, Adriana K, Barnes, S Whitney, Walker, John R, Gaulis, Swann, Hauy, Ervan, Brachmann, Saskia M, Krastel, Philipp, Studer, Christian, Riedl, Ralph, Estoppey, David, Aust, Thomas, Movva, N Rao, Wang, Zuncai, Salcius, Michael, Michaud, Gregory A, McAllister, Gregory, Murphy, Leon O, Tallarico, John A, Wilson, Christopher J, Dean, Charles R

“…Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G…”
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