Search Results - "BARNES, M. N"

Phase-I clinical trial of IL-12 plasmid lipopolymer complexes for the treatment of recurrent ovarian cancer by Anwer, K, Barnes, M N, Fewell, J, Lewis, D H, Alvarez, R D

“…A phase-I trial to assess the safety and tolerability of human interleukin-12 (IL-12) plasmid (phIL-12) formulated with a synthetic lipopolymer,…”
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A review of central 5-HT receptors and their function by Barnes, Nicholas M., Sharp, Trevor

“…It is now nearly 5 years since the last of the currently recognised 5-HT receptors was identified in terms of its cDNA sequence. Over this period, much effort…”
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Epithelial ovarian cancer: prevention, diagnosis, and treatment by Partridge, E. E, Barnes, M. N

“…The leading cause of death from gynecologic malignancies in the United States is epithelial ovarian cancer. The significant risk factor for development of…”
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Preclinical evaluation of a class of infectivity-enhanced adenoviral vectors in ovarian cancer gene therapy by WU, H, HAN, T, LAM, J. T, LEATH, C. A, DMITRIEV, I, KASHENTSEVA, E, BARNES, M. N, ALVAREZ, R. D, CURIEL, D. T

“…Ovarian carcinoma cells are often infected inefficiently by adenoviruses (Ad) due to low expression of coxsackie-adenovirus receptors (CAR), hindering the…”
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5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge by Barnes, N M

“…There is growing evidence that 5-HT3 receptor blockade will benefit patients with fatigue. Further research is needed to determine the mechanism underlying…”
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A Cancer Gene Therapy Approach Utilizing an Anti-erbB-2 Single-Chain Antibody-encoding Adenovirus (AD21): A Phase I Trial by Alvarez, R D, Barnes, M N, Gomez-Navarro, J, Wang, M, Strong, T V, Arafat, W, Arani, R B, Johnson, M R, Roberts, B L, Siegal, G P, Curiel, D T

“…The purpose of this Phase I study was to determine the feasibility of using an anti-erbB-2-encoding adenovirus (Ad21) to treat erbB-2-overexpressing ovarian…”
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Is central hyperacusis a symptom of 5-hydroxytryptamine (5-HT) dysfunction? by Marriage, J, Barnes, N M

“…The subjective symptom of hyperacusis is described. The terms 'hyperacusis' and 'phonophobia' are considered to be synonymous as there is no recognized…”
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5‐HT4 receptor‐mediated modulation of 5‐HT release in the rat hippocampus in vivo by Ge, Jian, Barnes, Nicholas M.

“…1 In the present study, the ability of the 5‐hydroxytryptamine4 receptor (5‐HT4 receptor) to modulate the release of 5‐HT in the hippocampus of freely‐moving…”
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Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv by ARAFAT, W. O, GOMEZ-NAVARRO, J, SIEGAL, G. P, ALVAREZ, R. D, HEMMINKI, A, NETTELBECK, D. M, CURIEL, D. T, BUCHSBAUM, D. J, XIANG, J, WANG, M, CASADO, E, BARKER, S. D, MAHASRESHTI, P. J, HAISMA, H. J, BARNES, M. N

“…Single chain antibodies (scFv) represent powerful interventional agents for the achievement of targeted therapeutics. The practical utility of these agents…”
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Ability of angiotensin II to modulate striatal dopamine release via the AT1 receptor in vitro and in vivo by Brown, D. Charles, Steward, Lucinda J., Ge, Jian, Barnes, Nicholas M.

“…1 The ability of angiotensin II to modulate dopamine release from rat striatal slices in vitro and in the intact rat striatum in vivo was assessed by the…”
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5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue by BARNES, J. M, BARNES, N. M, COSTALL, B, NAYLOR, R. J, TYERS, M. B

“…The release of cerebral acetylcholine from terminals in the cerebral cortex has been shown to be regulated by 5-hydroxytryptamine (5-HT) but it is not known…”
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Generation of a selective 5-HT3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus by MONK, S. A, DESAI, K, BRADY, C. A, WILLIAMS, J. M, LIN, L, PRINCIVALLE, A, HOPE, A. G, BARNES, N. M

“…The present study generated a polyclonal antibody (AP86/3) that recognises a peptide sequence of the h5-HT(3B) receptor subunit. Western blot analysis of…”
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Discovery of novel anxiolytic agents — The trials and tribulations of pre-clinical models of anxiety by Andrews, N.A, Papakosta, M, Barnes, N.M

“…Abstract Anxiety disorders are the most common class of mental disorders present in the general population with an estimated lifetime prevalence of any anxiety…”
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Transcriptional Targeting for Ovarian Cancer Gene Therapy by Casado, E., Nettelbeck, D.M., Gomez-Navarro, J., Hemminki, A., Gonzalez Baron, M., Siegal, G.P., Barnes, M.N., Alvarez, R.D., Curiel, D.T.

“…Ovarian carcinoma is a leading cause of cancer death in women. Though advances in conventional therapies have been achieved, long-term survival rates for most…”
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Effect of Aversive Stimulation on 5-Hydroxytryptamine and Dopamine Metabolism in the Rat Brain by Ge, J, Barnes, N.M, Costall, B, Naylor, R.J

“…GE, J., N. M. BARNES, B. COSTALL AND R. J. NAYLOR. Effect of aversive stimulation on 5-hydroxytryptamine and dopamine metabolism in the rat brain. PHARMACOL…”
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Selective labelling of 5-HT7 receptor recognition sites in rat brain using [3H]5-carboxamidotryptamine by STOWE, R. L, BARNES, N. M

“…The aim of the present study was to establish a radioligand binding assay to selectively label the native 5-HT7 receptor expressed in rat brain. In rat whole…”
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Group I mGlu receptor modulation of dopamine release in the rat striatum in vivo by Bruton, Rachel K., Ge, Jian, Barnes, Nicholas M.

“…The present study investigated the ability of mGlu (metabotropic glutamate) receptor to modulate dopamine release in the striatum of freely moving rats…”
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Ability of 5‐HT4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo by Steward, Lucinda J., Ge, Jian, Stowe, Rebecca L., Brown, D. Charles, Bruton, Rachel K., Stokes, Paul R. A., Barnes, Nicholas M.

“…1 The ability of 5‐HT4 (5‐hydroxytryptamine4) receptor ligands to modify dopamine release from rat striatal slices in vitro and in the striatum of freely…”
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Lymphocytes transport serotonin and dopamine: agony or ecstasy? by Gordon, John, Barnes, Nicholas M.

“…Lymphocytes apparently carry active transport systems for the neurotransmitters serotonin and dopamine. Meanwhile, pharmacological substrates for the…”
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Characterisation and autoradiographic localisation of 5-HT3 receptor recognition sites identified with [3H]-(S)-zacopride in the forebrain of the rat by Barnes, J M, Barnes, N M, Champaneria, S, Costall, B, Naylor, R J

“…The pharmacological characterisation and topographical distribution of [3H]-(S)-zacopride recognition sites in the forebrain of the rat was studied using…”
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