Search Results - "BARBUT, DENISE"

Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function by Alam, Md Masud, Yang, De, Li, Xiao-Qing, Liu, Jia, Back, Timothy Carrel, Trivett, Anna, Karim, Baktiar, Barbut, Denise, Zasloff, Michael, Oppenheim, Joost J.

“…Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD); however, its role in normal vertebrate physiology has remained unknown…”
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A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity by Stolzenberg, Ethan, Berry, Deborah, Yang, De, Lee, Ernest Y., Kroemer, Alexander, Kaufman, Stuart, Wong, Gerard C.L., Oppenheim, Joost J., Sen, Supti, Fishbein, Thomas, Bax, Ad, Harris, Brent, Barbut, Denise, Zasloff, Michael A.

“…Background: Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and…”
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Identification of SSRI-evoked antidepressant sensory signals by decoding vagus nerve activity by West, Christine L., McVey Neufeld, Karen-Anne, Mao, Yu-Kang, Stanisz, Andrew M., Forsythe, Paul, Bienenstock, John, Barbut, Denise, Zasloff, Michael, Kunze, Wolfgang A.

“…The vagus nerve relays mood-altering signals originating in the gut lumen to the brain. In mice, an intact vagus is required to mediate the behavioural effects…”
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Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres by McVey Neufeld, Karen-Anne, Mao, Yu-Kang, West, Christine L., Ahn, Matthew, Hameed, Hashim, Iwashita, Eiko, Stanisz, Andrew M., Forsythe, Paul, Barbut, Denise, Zasloff, Michael, Kunze, Wolfgang A.

“…Vagus nerve signaling is a key component of the gut-brain axis and regulates diverse physiological processes that decline with age. Gut to brain vagus firing…”
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Targeting neurons in the gastrointestinal tract to treat Parkinson's disease by Hauser, Robert A., Sutherland, Dean, Madrid, Juan A., Rol, Maria Angeles, Frucht, Steven, Isaacson, Stuart, Pagan, Fernando, Maddux, Brian N., Li, George, Tse, Winona, Walter, Benjamin L., Kumar, Rajeev, Kremens, Daniel, Lew, Mark F., Ellenbogen, Aaron, Oguh, Odinachi, Vasquez, Alberto, Kinney, William, Lowery, Matt, Resnick, Maria, Huff, Nicole, Posner, Jerry, Ballman, Karla V., Harvey, Brian E., Camilleri, Michael, Zasloff, Michael, Barbut, Denise

“…Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces…”
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Rapid Head Cooling Initiated Coincident With Cardiopulmonary Resuscitation Improves Success of Defibrillation and Post-Resuscitation Myocardial Function in a Porcine Model of Prolonged Cardiac Arrest by Tsai, Min-Shan, MD, Barbut, Denise, MD, MRCP, Tang, Wanchun, MD, FAHA, Wang, Hao, MD, Guan, Jun, MD, Wang, Tong, MD, Sun, Shijie, MD, Inderbitzen, Becky, Weil, Max Harry, MD, PhD, FAHA

“…[...]therapeutic hypothermia decreases metabolic demand in the myocardium at risk. Â Weight (kg) Blood pH Before CPR Blood pH After CPR Arterial PaO2 Before…”
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Impact of Embolization During Coronary Artery Bypass Grafting on Outcome and Length of Stay by Barbut, Denise, Lo, Yi-Wen, Gold, Jeffrey P, Trifiletti, Rosario R, Yao, F.S.Frank, Hager, David N, Hinton, Robert B, Isom, O.Wayne

“…Background. Transcranial Doppler ultrasonography detects emboli in most patients during coronary artery bypass grafting. However, the significance of these…”
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Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic by Limbocker, Ryan, Errico, Silvia, Barbut, Denise, Knowles, Tuomas P J, Vendruscolo, Michele, Chiti, Fabrizio, Zasloff, Michael

“…Covering: 1993 to 2021 (mainly 2017-2021)Alzheimer's and Parkinson's diseases are neurodegenerative conditions affecting over 50 million people worldwide…”
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Posterior Distribution of Infarcts in Strokes Related to Cardiac Operations by Barbut, Denise, Grassineau, Dominique, Lis, Eric, Heier, Linda, Hartman, Gregg S, Isom, O.Wayne

“…Background. Stroke complicates cardiac surgical procedures in a substantial number of patients. The mechanism of stroke is predominantly embolic, although…”
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Intranasal Perfluorochemical Spray for Preferential Brain Cooling in Sheep by Wolfson, Marla R., Malone, Daniel J., Wu, Jichuan, Hoffman, John, Rozenberg, Allan, Shaffer, Thomas H., Barbut, Denise

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Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol by Barletti, Beatrice, Lucchesi, Giacomo, Muscat, Stefano, Errico, Silvia, Barbut, Denise, Danani, Andrea, Zasloff, Michael, Grasso, Gianvito, Chiti, Fabrizio, Caminati, Gabriella

“…Trodusquemine is an amphipathic aminosterol that has recently shown therapeutic benefit in neurodegenerative diseases altering the binding of misfolded…”
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Local Brain Temperature Reduction Through Intranasal Cooling With the RhinoChill Device Preliminary Safety Data in Brain-Injured Patients by ABOU-CHEBL, Alex, SUNG, Gene, BARBUT, Denise, TORBEY, Michel

“…Hypothermia is neuroprotectant but currently available cooling methods are laborious, invasive, and require whole-body cooling. There is a need for less…”
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Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease : A Randomized Controlled Trial by Camilleri, Michael, Subramanian, Thyagarajan, Pagan, Fernando, Isaacson, Stuart, Gil, Ramon, Hauser, Robert A, Feldman, Mary, Goldstein, Mark, Kumar, Rajeev, Truong, Daniel, Chhabria, Nisha, Walter, Benjamin L, Eskenazi, Jonathan, Riesenberg, Robert, Burdick, Daniel, Tse, Winona, Molho, Eric, Robottom, Bradley, Bhatia, Perminder, Kadimi, Srinath, Klos, Kevin, Shprecher, David, Marquez-Mendoza, Otto, Hidalgo, Gonzalo, Grill, Stephen, Li, George, Mandell, Howard, Hughes, Mary, Stephenson, Sharisse, Vandersluis, Joel, Pfeffer, Michael, Duker, Andrew, Shivkumar, Vikram, Kinney, William, MacDougall, James, Zasloff, Michael, Barbut, Denise

“…Parkinson disease (PD) is associated with α-synuclein (αS) aggregation within enteric neurons. ENT-01 inhibits the formation of αS aggregates and improved…”
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854-P: ENT-03, a Centrally Acting Endogenous Spermine Bile Acid with PTP1B Inhibitory Activity, Has Potent Effects on Metabolism and Weight in a Mouse Model of Diet-Induced Obesity (DIO) by BARBUT, DENISE, BAUR, JOSEPH A., TITCHENELL, PAUL M., DAVIS, JAMES G., ZEMEL, MICHAEL B., ALEXANDER FLEMING, G., MOSES, ALAN C., ZASLOFF, MICHAEL

“…Background: We have discovered ENT-03, a spermine-bile acid of unprecedented structure in the brain of neonatal mice. ENT-03 appears postnatally at a time when…”
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Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine by Errico, Silvia, Lucchesi, Giacomo, Odino, Davide, Muscat, Stefano, Capitini, Claudia, Bugelli, Chiara, Canale, Claudio, Ferrando, Riccardo, Grasso, Gianvito, Barbut, Denise, Calamai, Martino, Danani, Andrea, Zasloff, Michael, Relini, Annalisa, Caminati, Gabriella, Vendruscolo, Michele, Chiti, Fabrizio

“…Trodusquemine is an aminosterol known to prevent the binding of misfolded protein oligomers to cell membranes and to reduce their toxicity in a wide range of…”
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Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine by Perni, Michele, Flagmeier, Patrick, Limbocker, Ryan, Cascella, Roberta, Aprile, Francesco A, Galvagnion, Céline, Heller, Gabriella T, Meisl, Georg, Chen, Serene W, Kumita, Janet R, Challa, Pavan K, Kirkegaard, Julius B, Cohen, Samuel I. A, Mannini, Benedetta, Barbut, Denise, Nollen, Ellen A. A, Cecchi, Cristina, Cremades, Nunilo, Knowles, Tuomas P. J, Chiti, Fabrizio, Zasloff, Michael, Vendruscolo, Michele, Dobson, Christopher M

“…The aggregation of α-synuclein, an intrinsically disordered protein that is highly abundant in neurons, is closely associated with the onset and progression of…”
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Asymmetric synthesis of ENT-03, the predicted mammalian ortholog of the dog fish shark aminosterol trodusquemine (MSI-1436) by Kinney, William A., Phillip Cox, D., Jones, Stephen R., Hessler, Edward J., Karnes, Harold A., Fevig, Thomas L., Hewitt, Bradley D., Sullivan, Ryan, Tseng, Nai-Wen, Pasion, Edward, Beale, Thomas, Rosner, Thorsten, Crouch, Ian T., D’Ambrosio, Stephen, Wade, Peter, Chen, Hui, Gao, Qi, Thompson, Andrew S., Muzzio, Miguel, Barbut, Denise, Zasloff, Michael A.

“…[Display omitted] ENT-03 was predicted to be the mammalian equivalent of trodusquemine, based on knowledge of the bile acids produced in mammals, such as…”
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Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes by Errico, Silvia, Lucchesi, Giacomo, Odino, Davide, Osman, Enass Youssef, Cascella, Roberta, Neri, Lorenzo, Capitini, Claudia, Calamai, Martino, Bemporad, Francesco, Cecchi, Cristina, Kinney, William A., Barbut, Denise, Relini, Annalisa, Canale, Claudio, Caminati, Gabriella, Limbocker, Ryan, Vendruscolo, Michele, Zasloff, Michael, Chiti, Fabrizio

“…Natural aminosterols are promising drug candidates against neurodegenerative diseases, like Alzheimer and Parkinson, and one relevant protective mechanism…”
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Intra-Arrest Transnasal Evaporative Cooling: A Randomized, Prehospital, Multicenter Study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness) by CASTREN, Maaret, NORDBERG, Per, STORM, Christian, PESENTI, Antonio, PACHL, Jan, GUERISSE, Fabien, ELSTE, Thomas, ROESSLER, Markus, FRITZ, Harald, DURNEZ, Pieterjan, BUSCH, Hans-Jörg, INDERBITZEN, Becky, SVENSSON, Leif, BARBUT, Denise, TACCONE, Fabio, VINCENT, Jean-Louise, DESRUELLES, Didier, EICHWEDE, Frank, MOLS, Pierre, SCHWAB, Tilmann, VERGNION, Michel

“…Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine. The aim of this study…”
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A novel, centrally acting mammalian aminosterol, ENT‐03, induces weight loss in obese and lean rodents by Barbut, Denise, Kinney, William A., Chen, Hsiao‐Huei, Stewart, Alexandre F. R., Hecksher‐Sørensen, Jacob, Zhang, Chen, Fleming, Alexander, Zemel, Michael, Zasloff, Michael

“…ENT‐03, a spermine bile acid we recently discovered in the brain of newborn mice acts centrally to regulate energy and metabolism. Obese, diabetic (ob/ob) mice…”
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