Search Results - "BARBOSA, Arnoldo"

Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children by Ariff, Amir, Song, Yong, Aguilar, Ruth, Nhabomba, Augusto, Manaca, Maria Nelia, Khoo, Siew-Kim, Wiertsema, Selma, Bassat, Quique, Barbosa, Arnoldo, Quintó, Llorenç, Laing, Ingrid A, Guinovart, Caterina, Alonso, Pedro L, Dobaño, Carlota, Le Souëf, Peter, Zhang, Guicheng

“…Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic…”
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Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial by Aponte, John J, MD, Aide, Pedro, MD, Renom, Montse, MD, Mandomando, Inacio, VetMed, Bassat, Quique, MD, Sacarlal, Jahit, MD, Manaca, M Nelia, BSc, Lafuente, Sarah, MD, Barbosa, Arnoldo, MD, Leach, Amanda, MRCPCH, Lievens, Marc, MSc, Vekemans, Johan, MD, Sigauque, Betuel, MD, Dubois, Marie-Claude, MSc, Demoitié, Marie-Ange, MSc, Sillman, Marla, MSc, Savarese, Barbara, RN, McNeil, John G, MD, Macete, Eusebio, MD, Ballou, W Ripley, MD, Cohen, Joe, PhD, Alonso, Pedro L, MD

“…Summary Background Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of…”
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High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection by Dobaño, Carlota, Berthoud, Tamara, Manaca, Maria Nelia, Nhabomba, Augusto, Guinovart, Caterina, Aguilar, Ruth, Barbosa, Arnoldo, Groves, Penny, Rodríguez, Mauricio H, Jimenez, Alfons, Quimice, Lazaro M, Aponte, John J, Ordi, Jaume, Doolan, Denise L, Mayor, Alfredo, Alonso, Pedro L

“…Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the…”
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IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy by Mayor, Alfredo, Dobaño, Carlota, Nhabomba, Augusto, Guinovart, Caterina, Jiménez, Alfons, Manaca, Maria Nelia, Aguilar, Ruth, Barbosa, Arnoldo, Rodríguez, Mauricio H, Cisteró, Pau, Quimice, Lazaro M, Menéndez, Clara, Aponte, John J, Ordi, Jaume, Chitnis, Chetan E, Alonso, Pedro L

“…Difficulties to disentangle the protective versus exposure role of anti-malarial antibodies hamper the identification of clinically-relevant immune targets…”
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Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children by GUICHENG ZHANG, NELIA MANACA, Maria, QUINTO, Llorenç, CANDELARIA, Pierre, NEE SCHULTZ, En, HAYDEN, Catherine M, GOLDBLATT, Jack, GUINOVART, Caterina, ALONSO, Pedro L, LESOUËF, Peter N, DOBANO, Carlota, MCNAMARA-SMITH, Michelle, MAYOR, Alfredo, NHABOMBA, Augusto, KATHERINE BERTHOUD, Tamara, KHOO, Siew-Kim, WIERTSEMA, Selma, AGUILAR, Ruth, BARBOSA, Arnoldo

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The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial by Guinovart, Caterina, Dobaño, Carlota, Bassat, Quique, Nhabomba, Augusto, Quintó, Llorenç, Manaca, Maria Nélia, Aguilar, Ruth, Rodríguez, Mauricio H, Barbosa, Arnoldo, Aponte, John J, Mayor, Alfredo G, Renom, Montse, Moraleda, Cinta, Roberts, David J, Schwarzer, Evelin, Le Souëf, Peter N, Schofield, Louis, Chitnis, Chetan E, Doolan, Denise L, Alonso, Pedro L

“…The rate of acquisition of naturally acquired immunity (NAI) against malaria predominantly depends on transmission intensity and age, although disentangling…”
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Plasmodium falciparum-Specific Cellular Immune Responses after Immunization with the RTS,S/AS02D Candidate Malaria Vaccine in Infants Living in an Area of High Endemicity in Mozambique by Barbosa, Arnoldo, Naniche, Denise, Aponte, John J, Manaca, M. Nelia, Mandomando, Inacio, Aide, Pedro, Sacarlal, Jahit, Renom, Montse, Lafuente, Sarah, Ballou, W. Ripley, Alonso, Pedro L

“…Results from clinical trials in areas where malaria is endemic have shown that immunization with RTS,S/AS02A malaria vaccine candidate induces partial…”
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Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology by Berthoud, Tamara K, Manaca, Maria Nelia, Quelhas, Diana, Aguilar, Ruth, Guinovart, Caterina, Puyol, Laura, Barbosa, Arnoldo, Alonso, Pedro L, Dobaño, Carlota

“…Multiplex cytokine profiling systems are useful tools for investigating correlates of protective immunity. Several Luminex and flow cytometry methods are…”
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Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique by Nhabomba, Augusto J, Guinovart, Caterina, Jiménez, Alfons, Manaca, Maria N, Quintó, Llorenç, Cisteró, Pau, Aguilar, Ruth, Barbosa, Arnoldo, Rodríguez, Mauricio H, Bassat, Quique, Aponte, John J, Mayor, Alfredo, Chitnis, Chetan E, Alonso, Pedro L, Dobaño, Carlota

“…The impact of the age of first Plasmodium falciparum infection on the rate of acquisition of immunity to malaria and on the immune correlates of protection has…”
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Invasion-Inhibitory Antibodies Inhibit Proteolytic Processing of Apical Membrane Antigen 1 of Plasmodium falciparum Merozoites by Dutta, Sheetij, Haynes, J. David, Moch, J. Kathleen, Barbosa, Arnoldo, Lanar, David E.

“…Apical membrane antigen 1 (AMA-1) is a promising vaccine candidate for Plasmodium falciparum malaria. Antibodies against AMA-1 of P. falciparum (PfAMA-1)…”
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Process Development and Analysis of Liver-Stage Antigen 1, a Preerythrocyte-Stage Protein-Based Vaccine for Plasmodium falciparum by Hillier, Collette J, Ware, Lisa A, Barbosa, Arnoldo, Angov, Evelina, Lyon, Jeffrey A, Heppner, D. Gray, Lanar, David E

“…Plasmodium falciparum liver-stage antigen 1 (LSA-1) is expressed solely in infected hepatocytes and is thought to have a role in liver schizogony and merozoite…”
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Mode of Action of Invasion-Inhibitory Antibodies Directed against Apical Membrane Antigen 1 of Plasmodium falciparum by Dutta, Sheetij, Haynes, J. David, Barbosa, Arnoldo, Ware, Lisa A, Snavely, Jeffrey D, Moch, J. Kathleen, Thomas, Alan W, Lanar, David E

“…Antibodies against apical membrane antigen 1 (AMA-1) of Plasmodium falciparum inhibit merozoite invasion into erythrocytes. Invasion-inhibitory polyclonal…”
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Purification, Characterization, and Immunogenicity of the Refolded Ectodomain of the Plasmodium falciparum Apical Membrane Antigen 1 Expressed in Escherichia coli by DUTTA, Sheetij, LALITHA, P. V, HAYNES, J. David, LANAR, David E, WARE, Lisa A, BARBOSA, Arnoldo, MOCH, J. Kathleen, VASSELL, Meredith A, FILETA, Bader B, KITOV, Svetlana, KOLODNY, Nelly, HEPPNER, D. Gray

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Murine Immune Responses to Liver-Stage Antigen 1 Protein FMP011, a Malaria Vaccine Candidate, Delivered with Adjuvant AS01B or AS02A by Brando, Clara, Ware, Lisa A, Freyberger, Helen, Kathcart, April, Barbosa, Arnoldo, Cayphas, Sylvie, Demoitie, Marie-Ange, Mettens, Pascal, Heppner, D. Gray, Lanar, David E

“…Liver-stage antigen 1 (LSA1) is expressed by Plasmodium falciparum only during the intrahepatic cell stage of the parasite's development. Immunoepidemiological…”
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Production of the Subdomains of the Plasmodium falciparum Apical Membrane Antigen 1 Ectodomain and Analysis of the Immune Response by LALITHA, P. V, WARE, Lisa A, BARBOSA, Arnoldo, DUTTA, Sheetij, MOCH, J. Kathleen, HAYNES, J. David, FILETA, Bader B, WHITE, Charles E, LANAR, David E

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Measurement of Antibody Levels against Region II of the Erythrocyte-Binding Antigen 175 of Plasmodium falciparum in an Area of Malaria Holoendemicity in Western Kenya by OHAS, Eunita A, ADAMS, John H, WAITUMBI, John N, OTAGO, Alloys S. S, BARBOSA, Arnoldo, LANAR, David E, STOUTE, José A

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Purification, Characterization, and Immunogenicity of a Disulfide Cross-Linked Plasmodium vivax Vaccine Candidate Antigen, Merozoite Surface Protein 1, Expressed in Escherichia coli by DUTTA, Sheetij, WARE, Lisa A, BARBOSA, Arnoldo, OCKENHOUSE, Christian F, LANAR, David E

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Analysis of Human Antibodies to Erythrocyte Binding Antigen 175 of Plasmodium falciparum by OKENU, Daniel M. N, RILEY, Eleanor M, BICKLE, Quentin D, AGOMO, Philip U, BARBOSA, Arnoldo, DAUGHERTY, Jon R, LANAR, David E, CONWAY, David J

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A Balanced Proinflammatory and Regulatory Cytokine Signature in Young African Children Is Associated With Lower Risk of Clinical Malaria by Dobaño, Carlota, Nhabomba, Augusto J, Manaca, Maria N, Berthoud, Tamara, Aguilar, Ruth, Quintó, Llorenç, Barbosa, Arnoldo, Rodríguez, Mauricio H, Jiménez, Alfons, Groves, Penny L, Santano, Rebeca, Bassat, Quique, Aponte, John J, Guinovart, Caterina, Doolan, Denise L, Alonso, Pedro L

“…Abstract Background The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive…”
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A balanced pro-inflammatory and regulatory cytokine signature in young African children is associated with lower risk of clinical malaria by Dobaño, Carlota, 1969, Nhabomba, Augusto J, Manaca, Maria N, Berthoud, Tamara, Aguilar, Ruth, Quintó, Llorenç, Barbosa, Arnoldo, Rodriguez, Mauricio H, Jiménez, Alfons, Groves, Penny L, Santano, Rebeca, Bassat Orellana, Quique, Aponte, John J, Guinovart, Caterina, Doolan, Denise L, Alonso, Pedro

“…Background: The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine…”
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