Search Results - "BARBARULO, Alessandro"

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  1. 1

    Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells by Blanchett, Sam, Dondelinger, Yves, Barbarulo, Alessandro, Bertrand, Mathieu J M, Seddon, Benedict

    Published in Frontiers in immunology (01-12-2022)
    “…The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of NF-κB activation. More recently, IKK has also been shown to repress RIPK1 dependent…”
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    Journal Article
  2. 2

    Hedgehog Signalling in the Embryonic Mouse Thymus by Barbarulo, Alessandro, Lau, Ching-In, Mengrelis, Konstantinos, Ross, Susan, Solanki, Anisha, Saldaña, José Ignacio, Crompton, Tessa

    Published in Journal of developmental biology (16-07-2016)
    “…T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor…”
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    NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells by Layzell, By Scott, Barbarulo, Alessandro, van Loo, Geert, Beyaert, Rudi, Seddon, Benedict

    Published in Cell death and differentiation (26-09-2024)
    “…IKK signalling is essential for survival of thymocytes by repressing RIPK1 induced cell death rather than its canonical function of activating NF-κB. The role…”
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  5. 5

    IKK promotes naïve T cell survival by repressing RIPK1-dependent apoptosis and activating NF-κB by Carty, Fiona, Layzell, Scott, Barbarulo, Alessandro, Islam, Farjana, Webb, Louise V, Seddon, Benedict

    Published in Science signaling (27-06-2023)
    “…The inhibitor of κB kinase (IKK) complex regulates the activation of the nuclear factor κB (NF-κB) family of transcription factors. In addition, IKK represses…”
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    Journal Article
  6. 6

    Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB by Webb, Louise V., Barbarulo, Alessandro, Huysentruyt, Jelle, Vanden Berghe, Tom, Takahashi, Nozomi, Ley, Steven, Vandenabeele, Peter, Seddon, Benedict

    Published in Immunity (Cambridge, Mass.) (19-02-2019)
    “…NF-κB (nuclear factor κB) signaling is considered critical for single positive (SP) thymocyte development because loss of upstream activators of NF-κB, such as…”
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  7. 7

    The transcriptional repressor Bcl6 promotes pre-TCR-induced thymocyte differentiation and attenuates Notch1 activation by Solanki, Anisha, Yánez, Diana C, Lau, Ching-In, Rowell, Jasmine, Barbarulo, Alessandro, Ross, Susan, Sahni, Hemant, Crompton, Tessa

    Published in Development (Cambridge) (07-10-2020)
    “…Pre-T-cell receptor (TCR) signal transduction is required for developing thymocytes to differentiate from CD4 CD8 double-negative (DN) cell to CD4 CD8…”
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    The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity by Furmanski, Anna L, Barbarulo, Alessandro, Solanki, Anisha, Lau, Ching-In, Sahni, Hemant, Saldana, Jose Ignacio, D'Acquisto, Fulvio, Crompton, Tessa

    Published in Journal of cell science (01-06-2015)
    “…Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory infiltrating immune cells. Hedgehog…”
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    Journal Article
  10. 10

    NVG-111, a novel ROR1xCD3 bispecific antibody for non-Hodgkin lymphoma by Granger, David, Gohil, Satyen, Barbarulo, Alessandro, Baccaro, Annalisa, Muczynski, Vincent, Chester, Kerry, Germaschewski, Fiona, Batten, Toby, Brown, Kathryn, Cook, Sarah, O'Donovan, Kieran, Jasani, Parag, Nathwani, Amit C., Phillips, Peter

    Published in Journal of clinical oncology (20-05-2021)
    “…Abstract only 7549 Background: Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is a type I transmembrane protein is highly expressed on an array of…”
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  11. 11

    The transcriptional repressor Bcl6 promotes pre-TCR induced differentiation to CD4+CD8+ thymocyte and attenuates Notch1 activation by Solanki, Anisha, Yánez, Diana C, Lau, Ching-In, Rowell, Jasmine, Barbarulo, Alessandro, Ross, Susan, Sahni, Hemant, Crompton, Tessa

    Published in Development (Cambridge) (01-01-2020)
    “…Pre-TCR signal transduction is required for developing thymocytes to differentiate from CD4-CD8- double negative (DN) to CD4+CD8+ double positive (DP) cell…”
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    Journal Article
  12. 12
  13. 13

    The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus by Lau, Ching-In, Barbarulo, Alessandro, Solanki, Anisha, Saldaña, José Ignacio, Crompton, Tessa

    Published in Oncotarget (11-04-2017)
    “…Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway activation through influencing structure of the primary cilium. Here we show…”
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  14. 14

    Notch3 and Canonical NF-κB Signaling Pathways Cooperatively Regulate Foxp3 Transcription by Barbarulo, Alessandro, Grazioli, Paola, Campese, Antonio F., Bellavia, Diana, Di Mario, Giuseppina, Pelullo, Maria, Ciuffetta, Ambra, Colantoni, Sara, Vacca, Alessandra, Frati, Luigi, Gulino, Alberto, Felli, Maria Pia, Screpanti, Isabella

    Published in The Journal of immunology (1950) (01-06-2011)
    “…Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression…”
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  15. 15

    A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation by Sahni, Hemant, Ross, Susan, Barbarulo, Alessandro, Solanki, Anisha, Lau, Ching-In, Furmanski, Anna, Saldaña, José Ignacio, Ono, Masahiro, Hubank, Mike, Barenco, Martino, Crompton, Tessa

    Published in Oncotarget (06-10-2015)
    “…Developing thymocytes require pre-TCR signalling to differentiate from CD4-CD8- double negative to CD4+CD8+ double positive cell. Here we followed the…”
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  16. 16

    Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription by Barbarulo, Alessandro, Grazioli, Paola, Campese, Antonio F, Bellavia, Diana, Di Mario, Giuseppina, Pelullo, Maria, Ciuffetta, Ambra, Colantoni, Sara, Vacca, Alessandra, Frati, Luigi, Gulino, Alberto, Felli, Maria Pia, Screpanti, Isabella

    Published in The Journal of immunology (1950) (01-06-2011)
    “…Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression…”
    Get full text
    Journal Article