Search Results - "BARBARULO, Alessandro"
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Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells
Published in Frontiers in immunology (01-12-2022)“…The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of NF-κB activation. More recently, IKK has also been shown to repress RIPK1 dependent…”
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2
Hedgehog Signalling in the Embryonic Mouse Thymus
Published in Journal of developmental biology (16-07-2016)“…T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor…”
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Aspirin Extrusion From Human Platelets Through Multidrug Resistance Protein-4–Mediated Transport
Published in Journal of the American College of Cardiology (09-08-2011)“…Objectives In this study we investigate: 1) the role of multidrug resistance protein-4 (MRP4), an organic anion unidirectional transporter, in modulating…”
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NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells
Published in Cell death and differentiation (26-09-2024)“…IKK signalling is essential for survival of thymocytes by repressing RIPK1 induced cell death rather than its canonical function of activating NF-κB. The role…”
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5
IKK promotes naïve T cell survival by repressing RIPK1-dependent apoptosis and activating NF-κB
Published in Science signaling (27-06-2023)“…The inhibitor of κB kinase (IKK) complex regulates the activation of the nuclear factor κB (NF-κB) family of transcription factors. In addition, IKK represses…”
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Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB
Published in Immunity (Cambridge, Mass.) (19-02-2019)“…NF-κB (nuclear factor κB) signaling is considered critical for single positive (SP) thymocyte development because loss of upstream activators of NF-κB, such as…”
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The transcriptional repressor Bcl6 promotes pre-TCR-induced thymocyte differentiation and attenuates Notch1 activation
Published in Development (Cambridge) (07-10-2020)“…Pre-T-cell receptor (TCR) signal transduction is required for developing thymocytes to differentiate from CD4 CD8 double-negative (DN) cell to CD4 CD8…”
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IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
Published in European journal of immunology (01-01-2019)“…The interferon‐inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate…”
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9
The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity
Published in Journal of cell science (01-06-2015)“…Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory infiltrating immune cells. Hedgehog…”
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10
NVG-111, a novel ROR1xCD3 bispecific antibody for non-Hodgkin lymphoma
Published in Journal of clinical oncology (20-05-2021)“…Abstract only 7549 Background: Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is a type I transmembrane protein is highly expressed on an array of…”
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The transcriptional repressor Bcl6 promotes pre-TCR induced differentiation to CD4+CD8+ thymocyte and attenuates Notch1 activation
Published in Development (Cambridge) (01-01-2020)“…Pre-TCR signal transduction is required for developing thymocytes to differentiate from CD4-CD8- double negative (DN) to CD4+CD8+ double positive (DP) cell…”
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12
Aspirin Extrusion From Human Platelets Through Multidrug Resistance Protein-4―Mediated Transport: Evidence of a Reduced Drug Action in Patients After Coronary Artery Bypass Grafting
Published in Journal of the American College of Cardiology (09-08-2011)“…In this study we investigate: 1) the role of multidrug resistance protein-4 (MRP4), an organic anion unidirectional transporter, in modulating aspirin action…”
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13
The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus
Published in Oncotarget (11-04-2017)“…Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway activation through influencing structure of the primary cilium. Here we show…”
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14
Notch3 and Canonical NF-κB Signaling Pathways Cooperatively Regulate Foxp3 Transcription
Published in The Journal of immunology (1950) (01-06-2011)“…Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression…”
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15
A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation
Published in Oncotarget (06-10-2015)“…Developing thymocytes require pre-TCR signalling to differentiate from CD4-CD8- double negative to CD4+CD8+ double positive cell. Here we followed the…”
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16
Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription
Published in The Journal of immunology (1950) (01-06-2011)“…Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression…”
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