Search Results - "BAPAT, Sharmila A"

Human ovarian cancer stem cells by Bapat, Sharmila A

“…The isolation and identification of stem-like cells in solid tumors or cancer stem cells (CSCs) have been exciting developments of the last decade, although…”
Get full text

Cancer stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy by Kusumbe, Anjali P, Bapat, Sharmila A

“…Tumor formation involves substantial cell division and genetic instability, but the relationship between quiescent cancer stem cells (CSC) and dividing…”
Get full text

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53‐Mediated Apoptosis and Acquiring a Stem‐Like Phenotype in Ovarian Cancer Cells by Kurrey, Nawneet K., Jalgaonkar, Swati P., Joglekar, Alok V., Ghanate, Avinash D., Chaskar, Prasad D., Doiphode, Rahul Y., Bapat, Sharmila A.

“…The transcriptional repressors Snail and Slug contribute to cancer progression by mediating epithelial‐mesenchymal transition (EMT), which results in tumor…”
Get full text

Migratory Metrics of Wound Healing: A Quantification Approach for in vitro Scratch Assays by Varankar, Sagar S, Bapat, Sharmila A

“…Metastatic dissemination generates an aggressive disease facilitated by enhanced migratory and invasive properties. Experimental approaches employ several and…”
Get full text

Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer by BAPAT, Sharmila A, MALI, Avinash M, KOPPIKAR, Chaitanyananda B, KURREY, Nawneet K

“…The cellular mechanisms underlying the increasing aggressiveness associated with ovarian cancer progression are poorly understood. Coupled with a lack of…”
Get full text

A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background by Narayanan, Aravindan, More, Ankita S, Talreja, Muskan, Mali, Avinash M, Vinay, Sannannagari Boya, Bapat, Sharmila A

“…Background Transcript variants and protein isoforms are central to unique tissue functions and maintenance of homeostasis, in addition to being associated with…”
Get full text

A monoclonal antibody against annexin A2 targets stem and progenitor cell fractions in tumors by Kalra, Rajkumar S., Soman, Gaurav S., Parab, Pradeep B., Mali, Avinash M., Varankar, Sagar S., Naik, Rutika R., Kamble, Swapnil C., Dhanjal, Jaspreet K., Bapat, Sharmila A.

“…•Development of a novel antibody (termed as mAb150) developed in our lab which targets annexin A2.•Although there are earlier reports of another monoclonal…”
Get full text

Discrete Molecular Classes of Ovarian Cancer Suggestive of Unique Mechanisms of Transformation and Metastases by GARDI, Nilesh L, DESHPANDE, Tejaswini U, KAMBLE, Swapnil C, BUDHE, Sagar R, BAPAT, Sharmila A

“…Tumor heterogeneity and subsistence of high-grade serous ovarian adenocarcinoma (HGSC) classes can be speculated from clinical incidences suggesting passive…”
Get full text

Expression proteomics predicts loss of RXR-γ during progression of epithelial ovarian cancer by Kalra, Rajkumar S, Bapat, Sharmila A

“…The process of cellular transformation involves cascades of molecular changes that are modulated through altered epigenetic, transcription, post-translational…”
Get full text

Pattern recognition in the landscape of seemingly random chimeric transcripts by Sridhar, Aksheetha, More, Ankita S., Jadhav, Amruta R., Patil, Komal, Mavlankar, Anuj, Dixit, Vaishnavi M., Bapat, Sharmila A.

“…The molecular and functional diversity generated by chimeric transcripts (CTs) that are derived from two genes is indicated to contribute to tumor cell…”
Get full text

Cell geometry distinguishes migration‐associated heterogeneity in two‐dimensional systems by Varankar, Sagar S, Hari, Kishore, Kartika, Sharon, Bapat, Sharmila A, Jolly, Mohit Kumar

“…In vitro migration assays are a cornerstone of cell biology and have found extensive utility in research. Over the past decade, several variations of the…”
Get full text

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas by Jolly, Mohit Kumar, Somarelli, Jason A., Sheth, Maya, Biddle, Adrian, Tripathi, Satyendra C., Armstrong, Andrew J., Hanash, Samir M., Bapat, Sharmila A., Rangarajan, Annapoorni, Levine, Herbert

“…Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and account for nearly all cancer-related deaths. Both metastasis and…”
Get full text

Enhanced levels of double-strand DNA break repair proteins protect ovarian cancer cells against genotoxic stress-induced apoptosis by Kalra, Rajkumar Singh, Bapat, Sharmila A

“…Earlier, proteomic profiling of a Serous Ovarian Carcinoma (SeOvCa) progression model in our lab had identified significantly enriched expression of three…”
Get full text

RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer by Shivalingappa, Pavan Kumar Mysuru, Sharma, Vaishali, Shiras, Anjali, Bapat, Sharmila A.

“…RNA-binding proteins (RBPs) are critical players in the post-transcriptional regulation of gene expression and are associated with each event in RNA…”
Get full text

Multivalent epigenetic marks confer microenvironment-responsive epigenetic plasticity to ovarian cancer cells by Bapat, Sharmila A., Jin, Victor, Berry, Nicholas, Balch, Curt, Sharma, Neeti, Kurrey, Nawneet, Zhang, Shu, Fang, Fang, Lan, Xun, Li, Meng, Kennedy, Brian, Bigsby, Robert M., Huang, Tim H-M, Nephew, Kenneth P.

“…"Epigenetic plasticity" refers to the capability of mammalian cells to alter their differentiation status via chromatin remodeling-associated alterations in…”
Get full text

CREBBP Re-arrangements affect protein function and lead to aberrant neuronal differentiation by Sharma, Neeti, Jadhav, Shweta P., Bapat, Sharmila A.

“…Biallelic inactivation of the CREB-binding protein ( CREBBP) a transcriptional co-activator produces an embryonic lethal phenotype in mice. In humans,…”
Get full text

Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype by Berry, Nicholas B, Bapat, Sharmila A

“…Aggressive epithelial ovarian cancer (EOC) is genetically and epigenetically distinct from normal ovarian surface epithelial cells (OSE) and early neoplasia…”
Get full text

Derivation of a fifteen gene prognostic panel for six cancers by Khirade, Mamata F., Lal, Girdhari, Bapat, Sharmila A.

“…The hallmarks of cancer deem biological pathways and molecules to be conserved. This approach may be useful for deriving a prognostic gene signature. Weighted…”
Get full text

Functional balance between Tcf21–Slug defines cellular plasticity and migratory modalities in high grade serous ovarian cancer cell lines by Varankar, Sagar S, More, Madhuri, Abraham, Ancy, Pansare, Kshama, Kumar, Brijesh, Narayanan, Nivedhitha J, Jolly, Mohit Kumar, Mali, Avinash M, Bapat, Sharmila A

“…Abstract Cellular plasticity and transitional phenotypes add to complexities of cancer metastasis that can be initiated by single cell epithelial to…”
Get full text

Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer by Singh, Anand Kamal, Chandra, Nishi, Bapat, Sharmila A

“…Resolution of aberrant epigenetic changes leading to altered gene expression during transformation and tumor progression is pertinent for mechanistic…”
Get full text