Search Results - "BANKERT, R. B"

In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres : Induction of tumor regression and potent antitumor immunity by EGILMEZ, N. K, JONG, Y. S, SABEL, M. S, JACOB, J. S, MATHIOWITZ, E, BANKERT, R. B

“…An alternative technology for the local and sustained delivery of cytokines to tumors for cancer immunotherapy was evaluated and shown here to induce tumor…”
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Human–SCID mouse chimeric models for the evaluation of anti-cancer therapies by Bankert, Richard B, Egilmez, Nejat K, Hess, Stephen D

“…The ability to engraft human tumors and human immunocompetent cells successfully in severe combined immunodeficient (SCID) mice has spawned the development and…”
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THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS by Abra, R. M., Bankert, R. B., Chen, F., Egilmez, N. K., Huang, K., Saville, R., Slater, J. L., Sugano, M., Yokota, S. J.

“…ABSTRACT Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin…”
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CD40 expression on human lung cancer correlates with metastatic spread by SABEL, M. S, YAMADA, M, KAWAGUCHI, Y, CHEN, F.-A, TAKITA, H, BANKERT, R. B

“…The poor prognosis associated with lung cancer is related to the high incidence of regional and distant metastasis. There is a crucial need to identify…”
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Comparison of human lung cancer/SCID mouse tumor xenografts and cell culture growth with patient clinical outcomes by ANDERSON, T. M, HESS, S. D, EGILMEZ, N. K, NWOGU, C. E, LENOX, J. M, BANKERT, R. B

“…Leukemic cell growth in SCID mice has been reported as a predictor of disease relapse. However, there is a paucity of literature regarding xenograft growth and…”
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Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule by CHEN, F. A, REPASKY, E. A, BANKERT, R. B

“…A single chain glycoprotein with an estimated molecular mass of 160 kD (gp160) was previously identified as a human lung tumor-associated antigen. This tumor…”
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Translocation of Spectrin and Protein Kinase C to a Cytoplasmic Aggregate Upon Lymphocyte Activation by Gregorio, Carol C., Kubo, Ralph T., Bankert, Richard B., Repasky, Elizabeth A.

“…We have previously reported that mammalian tissue lymphocytes exhibit significant heterogeneity with respect to the subcellular distribution of spectrin and…”
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Antitumor immune response of human peripheral blood lymphocytes coengrafted with tumor into severe combined immunodeficient mice by IWANUMA, Y, CHEN, F.-A, EGILMEZ, N. K, TAKITA, H, BANKERT, R. B

“…Here, it is established that human peripheral blood lymphocytes (HuPBLs), injected s.c. with a human lung tumor into severe combined immunodeficient (SCID)…”
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In vivo cytokine gene therapy of human tumor xenografts in SCID mice by liposome-mediated DNA delivery by Egilmez, N K, Cuenca, R, Yokota, S J, Sorgi, F, Bankert, R B

“…The human interleukin-2 (IL-2) gene was successfully delivered into established human tumor xenografts in SCID (severe combined immunodeficient) mice by…”
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Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes by WILLIAMS, S. S, ALOSCO, T. R, MAYHEW, E, LASIC, D. D, MARTIN, F. J, BANKERT, R. B

“…Incorporation of polyethylene glycol-derivatized phospholipids into liposomes results in carriers that can enhance the therapeutic efficacy of encapsulated…”
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Doxorubicin encapsulated in sterically stabilized liposomes is superior to free drug or drug-containing conventional liposomes at suppressing growth and metastases of human lung tumor xenografts by SAKAKIBARA, T, CHEN, F.-A, KIDA, H, KUNIEDA, K, CUENCA, R. E, MARTIN, F. J, BANKERT, R. B

“…Liposomes containing polyethylene glycol-derivatized phospholipids are able to evade the reticuloendothelial system and thereby remain in circulation for…”
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Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model by EGILMEZ, N. K, JONG, Y. S, IWANUMA, Y, JACOB, J. S, SANTOS, C. A, CHEN, F.-A, MATHIOWITZ, E, BANKERT, R. B

“…A novel biodegradable poly(lactic acid) microsphere formulation was evaluated for in vivo cytokine immunotherapy of cancer in a human tumor xenograft/ severe…”
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Human lung tumor growth established in the lung and subcutaneous tissue of mice with severe combined immunodeficiency by REDDY, S, PICCIONE, D, TAKITA, H, BANKERT, R. B

“…We report here that a mouse mutant (C.B-17 scid) which lacks functional B- and T-lymphocytes can be used to propagate a human lung tumor. The…”
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Human inflammatory cells within the tumor microenvironment of lung tumor xenografts mediate tumor growth suppression in situ that depends on and is augmented by interleukin-12 by SUGIYAMA, Yasuyuki, KATO, Motohisa, CHEN, Fang-An, WILLIAMS, Scott S, KAWAGUCHI, Yoshihiro, MIYA, Kiichi, JONG, Yong S, MATHIOWITZ, Edith, EGILMEZ, Nejat K, BANKERT, Richard B

“…The human tumor microenvironment includes a mixture of tumor cells, inflammatory cells, fibroblasts, and endothelial cells, all of which are tethered to an…”
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Growth of human tumor xenografts in SCID mice quantified using an immunoassay for tumor marker protein in serum by Conway, Thomas F, Sabel, Michael S, Sugano, Masahiko, Frelinger, John G, Egilmez, Nejat K, Chen, Fang-An, Bankert, Richard B

“…The accurate measurement of the response of a tumor to a given treatment is critical to evaluating novel therapeutic modalities. An experimental design is…”
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Monoclonal antibodies directed against the T-cell activation molecule CD137 (interleukin-A or 4-1BB) block human lymphocyte-mediated suppression of tumor xenografts in severe combined immunodeficient mice by SABEL, M. S, CONWAY, T. F, CHEN, F.-A, BANKERT, R. B

“…A monoclonal antibody specific for the human analog of the murine T-cell activation molecule 4-1BB was generated and is shown here to react selectively with…”
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Heterogeneity in Lymphocyte Spectrin Distribution: Ultrastructural Identification of a New Spectrin-Rich Cytoplasmic Structure by Black, Jennifer D., Koury, Stephen T., Bankert, Richard B., Repasky, Elizabeth A.

“…Spectrin-like proteins are found in a wide variety of non-erythroid cells where they generally occur in the cell cortex near the plasma membrane. To determine…”
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Cytokines delivered by biodegradable microspheres promote effective suppression of human tumors by human peripheral blood lymphocytes in the SCID-winn model by EGILMEZ, N. K, JONG, Y. S, HESS, S. D, JACOB, J. S, MATHIOWITZ, E, BANKERT, R. B

“…A new technology for the local and sustained delivery of immunostimulatory molecules to the tumor environment for cancer immunotherapy was evaluated. The…”
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Engraftment of human tumor-infiltrating lymphocytes and the production of anti-tumor antibodies in SCID mice by Williams, SS, Chen, FA, Kida, H, Yokata, S, Miya, K, Kato, M, Barcos, MP, Wang, HQ, Alosco, T, Umemoto, T, Croy, BA, Repasky, EA, Bankert, RB

“…We report here the placement of nondisrupted 1-mm3 pieces of fresh human lung tumor biopsy tissue into the subcutis of severe combined immunodeficient (SCID)…”
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IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells by Broderick, Lori, Brooks, Stephen P., Takita, Hiroshi, Baer, Alan N., Bernstein, Joel M., Bankert, Richard B.

“…Memory T cells in human non-small cell lung cancer are unresponsive to progressing tumors. T cells were evaluated at the single cell level by imaging the…”
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