Search Results - "BANGA, J. P."

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes by SCHLOSSER, M, BANGA, J. P, MADEC, A. M, BINDER, K. A, STREBELOW, M, RJASANOWSKI, I, WASSMUTH, R, GILLIAM, L. K, LUO, D, HAMPE, C. S

“…Progression to type 1 diabetes is associated with intramolecular epitope spreading to disease-specific antibody epitopes located in the middle region of…”
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Lessons from mouse models of Graves’ disease by Eckstein, A., Philipp, S., Goertz, G., Banga, J. P., Berchner-Pfannschmidt, U.

“…Graves’ disease (GD) is an autoimmune condition with the appearance of anti-TSH receptor (TSHR) autoantibodies in the serum. The consequence is the development…”
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Modeling Graves' Orbitopathy in Experimental Graves' Disease by Banga, J P, Moshkelgosha, S, Berchner-Pfannschmidt, U, Eckstein, A

“…Graves' orbitopathy (GO), also known as thyroid eye disease is an inflammatory disease of the orbital tissue of the eye that arises as a consequence of…”
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Autoimmune Thyroid Diseases by Banga, J P, Schott, M

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Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self‐tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathy by Schlüter, A., Horstmann, M., Diaz‐Cano, S., Plöhn, S., Stähr, K., Mattheis, S., Oeverhaus, M., Lang, S., Flögel, U., Berchner‐Pfannschmidt, U., Eckstein, A., Banga, J. P.

“…Summary Experimental models of Graves' hyperthyroid disease accompanied by Graves' orbitopathy (GO) can be induced efficiently in susceptible inbred strains of…”
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Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA‐DRB10301 (DR3) transgenic mice by FLYNN, J. C., GARDAS, A., WAN, Q., GORA, M., ALSHARABI, G., WEI, W. Z., GIRALDO, A. A., DAVID, C. S., KONG, Y. M., BANGA, J. P.

“…SUMMARY Murine experimental autoimmune thyroiditis (EAT), characterized by thyroid destruction after immunization with thyroglobulin (Tg), has long been a…”
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Graves’ hyperthyroidism and thyroiditis in HLA‐DRB10301 (DR3) transgenic mice after immunization with thyrotropin receptor DNA by FLYNN, J. C., RAO, P. V., GORA, M., ALSHARABI, G., WEI, W., GIRALDO, A. A., DAVID, C. S., BANGA, J. P., KONG, Y. M.

“…SUMMARY Familial and twin studies in Caucasians have established that the MHC class II allele HLA‐DRB1*0301 (DR3) is a strong susceptibility gene in Graves’…”
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Evaluation of conformational epitopes on thyroid peroxidase by antipeptide antibody binding and mutagenesis by GORA, M., GARDAS, A., WIKTOROWICZ, W., HOBBY, P., WATSON, P. F., WEETMAN, A. P., SUTTON, B. J., BANGA, J. P.

“…SUMMARY Autoantibodies to thyroid peroxidase (TPO) recognize predominantly conformational epitopes, which are restricted to two distinct determinants, termed…”
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Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles by Maruyama, T, Oak, S, Hall, T.R, Banga, J.P, Ortqvist, E, Ettinger, R.A, Endl, J, Hampe, C.S

“…Type 1 diabetes (T1D) is an autoimmune disease with a strong human leucocyte antigen (HLA) class II association. Depending on geographic locations, the…”
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Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient by BANGA, J. P., MOORE, J. K., DUHINDAN, N., MADEC, A. M., VAN ENDERT, P. M., ORGIAZZI, J., ENDL, J.

“…SUMMARY We used a GAD65‐specific human B–T cell line cognate system in vitro to investigate the modulation of GAD65 presentation by autoantibody, assessed in a…”
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Induction of hyperthyroidism in mice by intradermal immunization with DNA encoding the thyrotropin receptor by BARRETT, K., LIAKATA, E., RAO, P. V., WATSON, P. F., WEETMAN, A. P., LYMBERI, P., BANGA, J. P., CARAYANNIOTIS, G.

“…SUMMARY Intramuscular injection with plasmid DNA encoding the human thyrotropin receptor (TSHR) has been known to elicit symptoms of Graves’ disease (GD) in…”
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Multiplicity of the antibody response to GAD65 in Type I diabetes by GILLIAM, L. K., BINDER, K. A., BANGA, J. P., MADEC, A.‐M., ORTQVIST, E., KOCKUM, I., LUO, D., HAMPE, C. S.

“…SUMMARY Type I diabetes (TID) is an autoimmune disease characterized in part by the presence of autoantibodies directed against glutamic acid decarboxylase 65…”
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Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune disorders by POWERS, A. C, BAVIK, K, TREMBLE, J, DAW, K, SCHERBAUM, W. A, BANGA, J. P

“…Autoantibodies to GAD, an important marker of the autoimmune process in type I or insulin‐dependent diabetes mellitus (IDDM), are also found in non‐diabetic…”
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Two amino acids in glutamic acid decarboxylase act in concert for maintainance of conformational determinants recognised by Type I diabetic autoantibodies by TREE, T. I. M, MORGENTHALER, N. G, DUHINDAN, N, HICKS, K. E, MADEC, A.-M, SCHERBAUM, W. A, BANGA, J. P

“…Aims/hypothesis. Glutamic acid decarboxylase 65 is a major autoantigen in Type I (insulin-dependent) diabetes mellitus, autoimmune polyendocrine syndrome and…”
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Monoclonal antibodies to the human TSH receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells by Nicholson, L B, Vlase, H, Graves, P, Nilsson, M, Molne, J, Huang, G C, Morgenthaler, N G, Davies, T F, McGregor, A M, Banga, J P

“…We have characterized four murine monoclonal antibodies (mAbs) to the extracellular domain of the human TSH receptor (TSH-R.E), the target autoantigen of…”
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Human thyroid peroxidase (TPO) isoforms, TPO-1 and TPO-2: Analysis of protein expression in Graves' thyroid tissue by GARDAS, A, LEWARTOWSKA, A, SUTTON, B. J, PASIEKA, Z, MCGREGOR, A. M, BANGA, J. P

“…Thyroid peroxidase (TPO) is the key enzyme involved in the biosynthesis of thyroid hormones and is an important autoantigen in autoimmune thyroid disease…”
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Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease : A comparison with those present in type 1 diabetes by TREMBLE, J, MORGENTHALER, N. G, VLUG, A, POWERS, A. C, CHRISTIE, M. R, SCHERBAUM, W. A, BANGA, J. P

“…Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in a number of autoimmune disorders, such as insulin-dependent (type 1) diabetes mellitus…”
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Parathyroid hormone-related peptide in normal human fetal development by Moniz, C, Burton, P B, Malik, A N, Dixit, M, Banga, J P, Nicolaides, K, Quirke, P, Knight, D E, McGregor, A M

“…Parathyroid hormone-related peptide (PTHrP) has been detected in fetal serum and amniotic fluid. Using a combination of immunocytochemistry and molecular…”
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The thyrotrophin hormone receptor of Graves' disease: overexpression of the extracellular domain in insect cells using recombinant baculovirus, immunoaffinity purification and analysis of autoantibody binding by Huang, G C, Page, M J, Nicholson, L B, Collison, K S, McGregor, A M, Banga, J P

“…Since the cloning of the TSH receptor (TSH-R), the target autoantigen of Graves' disease, the receptor has been expressed in a variety of eukaryotic cells to…”
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Induction of thyroiditis in mice with thyrotropin receptor lacking serologically dominant regions by Wang, S. H., Carayanniotis, G., Zhang, Y., Gupta, M., Mcgregor, A. M., Banga, J. P.

“…Grave's disease (GD) is characterized by pathogenic autoantibodies to the human thyrotropin receptor (hTSH‐R), and is frequently associated with a lymphocytic…”
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