Search Results - "BAN AN KHAW"

Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis by Sukumaran, Abitha, Chang, JuOae, Han, Murui, Mintri, Shrutika, Khaw, Ban-An, Kim, Jonghan

“…Cardiac damage associated with iron overload is the most common cause of morbidity and mortality in patients with hereditary hemochromatosis, but the precise…”
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External magnet improves antitumor effect of vinblastine and the suppression of metastasis by Dandamudi, Suman, Patil, Vishwesh, Fowle, William, Khaw, Ban‐An, Campbell, Robert B.

“…The use of magnetic drug targeting (MDT) to selectively deliver chemotherapeutic drugs to tumor cells is a widely investigated approach; however, the notion of…”
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Palmitoyl Ascorbate Liposomes and Free Ascorbic Acid: Comparison of Anticancer Therapeutic Effects Upon Parenteral Administration by Sawant, Rupa R., Vaze, Onkar S., Wang, Tao, D’Souza, Gerard G. M., Rockwell, Karen, Gada, Keyur, Khaw, Ban-An, Torchilin, Vladimir P.

“…ABSTRACT Purpose To evaluate and compare anticancer therapeutic effect of palmitoyl ascorbate liposomes (PAL) and free ascorbic acid (AA). Methods Liposomes…”
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Apoptosis in Myocytes in End-Stage Heart Failure by Narula, Jagat, Haider, Nezam, Virmani, Renu, DiSalvo, Thomas G, Kolodgie, Frank D, Hajjar, Roger J, Schmidt, Ulrich, Semigran, Marc J, Dec, G. William, Khaw, Ban-An

“…Heart failure is estimated to affect over 3 million people in the United States. 1 Approximately 400,000 new cases of heart failure are diagnosed each year…”
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Imaging doxorubicin and polymer-drug conjugates of doxorubicin-induced cardiotoxicity with bispecific anti-myosin-anti-DTPA antibody and Tc-99m-labeled polymers by Panwar, Rajiv, Bhattarai, Prashant, Patil, Vishwesh, Gada, Keyur, Majewski, Stan, Khaw, Ban An

“…Radiolabeled anti-myosin imaging is well-established for imaging doxorubicin-induced cardiotoxicity. However, to enable imaging of drug-induced cardiotoxicity…”
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Design and In Vitro Evaluation of Bispecific Complexes and Drug Conjugates of Anticancer Peptide, LyP-1 in Human Breast Cancer by Timur, Selin Seda, Bhattarai, Prashant, Gürsoy, Reyhan Neslihan, Vural, İmran, Khaw, Ban-An

“…Purpose LyP-1, a nine-amino-acid tumor homing peptide, selectively binds to its cognate receptor, p32. Overexpression of p32 in certain tumors should allow use…”
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Bispecific antibody complex pre-targeting and targeted delivery of polymer drug conjugates for imaging and therapy in dual human mammary cancer xenografts: Targeted polymer drug conjugates for cancer diagnosis and therapy by Khaw, Ban-An, Gada, Keyur S., Patil, Vishwesh, Panwar, Rajiv, Mandapati, Savitri, Hatefi, Arash, Majewski, Stan, Weisenberger, Andrew

“…Introduction Doxorubicin, a frontline chemotherapeutic agent, limited by its cardiotoxicity and other tissue toxicities, was conjugated to N -terminal…”
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ATP-containing immunoliposomes specific for cardiac myosin by Liang, Wei, Levchenko, Tatyana, Khaw, Ban-An, Torchilin, Vladimir

“…The application of ATP-loaded liposomes has been shown effective against ischemic damage in several tissues. In this study, we have prepared ATP-containing…”
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Indium 111 antimyosin and Tc-99m glucaric acid for noninvasive identification of oncotic and apoptotic myocardial necrosis by Khaw, Ban-An, Silva, Jose Da, Petrov, Artiom, Hartner, William

“…Background. Noninvasive imaging techniques would be highly desirable to differentiate oncotic from apoptotic cell death. Indium 111 antimyosin and technetium…”
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Design of targeted cardiovascular molecular imaging probes by Anderson, Carolyn J, Bulte, Jeff W M, Chen, Kai, Chen, Xiaoyuan, Khaw, Ban-An, Shokeen, Monica, Wooley, Karen L, VanBrocklin, Henry F

“…Molecular imaging relies on the development of sensitive and specific probes coupled with imaging hardware and software to provide information about the…”
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In vitro demonstration of enhanced prostate cancer toxicity: pretargeting with Bombesin bispecific complexes and targeting with polymer-drug-conjugates by Patil, Vishwesh, Gada, Keyur, Panwar, Rajiv, Majewski, Stan, Tekabe, Yared, Varvarigou, Alexandra, Khaw, Ban-An

“…Abstract Background: Bombesin has been used to target Bombesin receptor, a growth receptor, which is over-expressed in many cancers, including prostate cancer…”
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Plug and seal: Prevention of hypoxic cardiocyte death by sealing membrane lesions with antimyosin-liposomes by Khaw, Ban-An, Torchilin, Vladimir P, Vural, Imran, Narula, Jagat

“…The hallmark of cell death is the development of cell membrane lesions. Such lesions in the myocardium are usually associated with acute myocardial infarction…”
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Imaging small human prostate cancer xenografts after pretargeting with bispecific bombesin-antibody complexes and targeting with high specific radioactivity labeled polymer-drug conjugates by Patil, Vishwesh, Gada, Keyur, Panwar, Rajiv, Varvarigou, Alexandra, Majewski, Stan, Weisenberger, Andrew, Ferris, Craig, Tekabe, Yared, Khaw, Ban-An

“…Purpose Pretargeting with bispecific monoclonal antibodies (bsMAb) for tumor imaging was developed to enhance target to background activity ratios…”
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Apoptosis and the heart by Narula, J, Kharbanda, S, Khaw, B A

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Cytoskeletal-antigen specific immunoliposome-targeted in vivo preservation of myocardial viability by Khaw, Ban-An, DaSilva, Jose, Hartner, William C.

“…Preservation of cell viability using Cytoskeletal-antigen Specific ImmunoLiposomes (antimyosin-CSIL) has been demonstrated in cell cultures. The current study…”
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Protective Effect of Butylated Hydroxyanisole on Adriamycin-induced Cardiotoxicity by Vora, Jayesh, Khaw, Ban-An, Narula, Jagat, Boroujerdi, Mehdi

“…Adriamycin has a wide spectrum of antitumour activity with dose‐related cardiotoxicity as a major side effect. This cardiotoxicity has been suggested to result…”
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Pretargeted gamma imaging of murine metastatic melanoma lung lesions with bispecific antibody and radiolabeled polymer drug conjugates by Gada, Keyur S, Patil, Vishwesh, Panwar, Rajiv, Majewski, Stan, Tekabe, Yared, Khaw, Ban-An

“…INTRODUCTIONBispecific monoclonal antibodies (bsMAbs) have been developed as a pretargeting tool to reduce background activity, thereby increasing target to…”
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Bispecific antibody complex pre-targeted delivery of polymer–drug conjugates for cancer therapy by Gada, Keyur S., Patil, Vishwesh, Panwar, Rajiv, Hatefi, Arash, Khaw, Ban-An

“…The pretargeting approach using bispecific affibody–antibody complex (BAAC) and targeting of chemotherapeutic drug loaded polymers have been used in breast…”
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Gamma imaging of atherosclerotic plaques by Khaw, Ban-An

“…Noninvasive gamma imaging of atherosclerotic plaques targets various metabolic aspects of atherogenesis. Vascular endothelial dysfunction or denudation…”
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Complementary roles of antibody affinity and specificity for in vivo diagnostic cardiovascular targeting: How specific is antimyosin for irreversible myocardial damage? by Khaw, Ban-An, Petrov, Artiom, Narula, Jagat

“…Background. Identification of irreversible myocyte injury with antimyosin antibody imaging depends on both antibody specificity and affinity. To characterize…”
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