Search Results - "BALAZS, Alejandro B"

Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids by Huang, Qin, Chan, Ken Y, Tobey, Isabelle G, Chan, Yujia Alina, Poterba, Tim, Boutros, Christine L, Balazs, Alejandro B, Daneman, Richard, Bloom, Jonathan M, Seed, Cotton, Deverman, Benjamin E

“…The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application…”
Get full text

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant by Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.

“…Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of…”
Get full text

Antibody-based protection against HIV infection by vectored immunoprophylaxis by Balazs, Alejandro B., Chen, Joyce, Hong, Christin M., Rao, Dinesh S., Yang, Lili, Baltimore, David

“…A single injection of a viral vector that encodes antibodies able to neutralize most HIV strains protects humanized mice from HIV infection. Anti-HIV…”
Get full text

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy by Sigal, Alex, Kim, Jocelyn T., Balazs, Alejandro B., Dekel, Erez, Mayo, Avi, Milo, Ron, Baltimore, David

“…HIV persists through continued transmission Antiretroviral therapy suppresses, but does not eradicate, HIV infection. Low-level viraemia continues for life…”
Get full text

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
Get full text

Adeno-associated virus gene delivery of broadly neutralizing antibodies as prevention and therapy against HIV-1 by Lin, Allen, Balazs, Alejandro B

“…Vectored gene delivery of HIV-1 broadly neutralizing antibodies (bNAbs) using recombinant adeno-associated virus (rAAV) is a promising alternative to…”
Get full text

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission by Balazs, Alejandro B, Ouyang, Yong, Hong, Christin M, Chen, Joyce, Nguyen, Steven M, Rao, Dinesh S, An, Dong Sung, Baltimore, David

“…Delivery of HIV-specific neutralizing antibodies by adeno-associated virus vectors—termed vectored immunoprophylaxis (VIP)—has been shown to protect mice or…”
Get full text

Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Naive Nursing Home Residents by Canaday, David H, Carias, Lenore, Oyebanji, Oladayo A, Keresztesy, Debbie, Wilk, Dennis, Payne, Michael, Aung, Htin, St. Denis, Kerri, Lam, Evan C, Rowley, Christopher F, Berry, Sarah D, Cameron, Cheryl M, Cameron, Mark J, Wilson, Brigid, Balazs, Alejandro B, Gravenstein, Stefan, King, Christopher L

“…Abstract After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing…”
Get full text

Broad protection against influenza infection by vectored immunoprophylaxis in mice by Balazs, Alejandro B, Bloom, Jesse D, Hong, Christin M, Rao, Dinesh S, Baltimore, David

“…Gene therapy encoding a single influenza broadly neutralizing antibody durably protects even immunocompromised mice from illness caused by diverse influenza…”
Get full text

Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms by Atyeo, Caroline G., Shook, Lydia L., Brigida, Sara, De Guzman, Rose M., Demidkin, Stepan, Muir, Cordelia, Akinwunmi, Babatunde, Baez, Arantxa Medina, Sheehan, Maegan L., McSweeney, Erin, Burns, Madeleine D., Nayak, Ruhi, Kumar, Maya K., Patel, Chinmay D., Fialkowski, Allison, Cvrk, Dana, Goldfarb, Ilona T., Yonker, Lael M., Fasano, Alessio, Balazs, Alejandro B., Elovitz, Michal A., Gray, Kathryn J., Alter, Galit, Edlow, Andrea G.

“…The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing of…”
Get full text

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output by O'Connell, Ryan M., Chaudhuri, Aadel A., Rao, Dinesh S., Gibson, William S. J., Balazs, Alejandro B., Baltimore, David

“…The production of blood cells depends on a rare hematopoietic stem-cell (HSC) population, but the molecular mechanisms underlying HSC biology remain…”
Get full text

Broadly neutralizing antibodies abrogate established hepatitis C virus infection by de Jong, Ype P, Dorner, Marcus, Mommersteeg, Michiel C, Xiao, Jing W, Balazs, Alejandro B, Robbins, Justin B, Winer, Benjamin Y, Gerges, Sherif, Vega, Kevin, Labitt, Rachael N, Donovan, Bridget M, Giang, Erick, Krishnan, Anuradha, Chiriboga, Luis, Charlton, Michael R, Burton, Dennis R, Baltimore, David, Law, Mansun, Rice, Charles M, Ploss, Alexander

“…In most exposed individuals, hepatitis C virus (HCV) establishes a chronic infection; this long-term infection in turn contributes to the development of liver…”
Get more information

Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice by Deal, Cailin, Balazs, Alejandro B., Espinosa, Diego A., Zavala, Fidel, Baltimore, David, Ketner, Gary

“…Malaria caused by Plasmodium falciparum kills nearly one million children each year and imposes crippling economic burdens on families and nations worldwide…”
Get full text

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St, Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display…”
Get full text

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection by Saunders, Kevin O, Wang, Lingshu, Joyce, M Gordon, Yang, Zhi-Yong, Balazs, Alejandro B, Cheng, Cheng, Ko, Sung-Youl, Kong, Wing-Pui, Rudicell, Rebecca S, Georgiev, Ivelin S, Duan, Lijie, Foulds, Kathryn E, Donaldson, Mitzi, Xu, Ling, Schmidt, Stephen D, Todd, John-Paul, Baltimore, David, Roederer, Mario, Haase, Ashley T, Kwong, Peter D, Rao, Srinivas S, Mascola, John R, Nabel, Gary J

“…Broadly neutralizing antibodies (bnAbs) can prevent lentiviral infection in nonhuman primates and may slow the spread of human immunodeficiency virus type 1…”
Get full text

Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge by Welles, Hugh C, Jennewein, Madeleine F, Mason, Rosemarie D, Narpala, Sandeep, Wang, Lingshu, Cheng, Cheng, Zhang, Yi, Todd, John-Paul, Lifson, Jeffrey D, Balazs, Alejandro B, Alter, Galit, McDermott, Adrian B, Mascola, John R, Roederer, Mario

“…Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such…”
Get full text

Neutralization and binding antibody response to second bivalent COVID‐19 vaccination in nursing home residents by Oyebanji, Oladayo A., Abul, Yasin, Wilson, Brigid M., Bosch, Jurgen, Didion, Elise M., Paxitzis, Alexandra N., Sundheimer, Nicholas, Ragavapuram, Vaishnavi, Wilk, Dennis, Keresztesy, Debbie, Aung, Htin, Cao, Yi, King, Christopher L., Balazs, Alejandro B., White, Elizabeth M., Gravenstein, Stefan, Canaday, David H.

Get full text

Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment by Vanuytsel, Kim, Villacorta-Martin, Carlos, Lindstrom-Vautrin, Jonathan, Wang, Zhe, Garcia-Beltran, Wilfredo F., Vrbanac, Vladimir, Parsons, Dylan, Lam, Evan C., Matte, Taylor M., Dowrey, Todd W., Kumar, Sara S., Li, Mengze, Wang, Feiya, Yeung, Anthony K., Mostoslavsky, Gustavo, Dries, Ruben, Campbell, Joshua D., Belkina, Anna C., Balazs, Alejandro B., Murphy, George J.

“…The human hematopoietic stem cell harbors remarkable regenerative potential that can be harnessed therapeutically. During early development, hematopoietic stem…”
Get full text

T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells by Schiff, Abigail E., Linder, Alice H., Luhembo, Shillah N., Banning, Stephanie, Deymier, Martin J., Diefenbach, Thomas J., Dickey, Amy K., Tsibris, Athe M., Balazs, Alejandro B., Cho, Josalyn L., Medoff, Benjamin D., Walzl, Gerhard, Wilkinson, Robert J., Burgers, Wendy A., Corleis, Björn, Kwon, Douglas S.

“…Alveolar macrophages (AMs) are critical for defense against airborne pathogens and AM dysfunction is thought to contribute to the increased burden of pulmonary…”
Get full text

Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting by Hauser, Blake M., Sangesland, Maya, St. Denis, Kerri J., Lam, Evan C., Case, James Brett, Windsor, Ian W., Feldman, Jared, Caradonna, Timothy M., Kannegieter, Ty, Diamond, Michael S., Balazs, Alejandro B., Lingwood, Daniel, Schmidt, Aaron G.

“…Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved…”
Get full text