Search Results - "BALAMURUGAN, A. N"

Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis by Sutherland, David E.R., MD, PhD, FACS, Radosevich, David M., RN, PhD, Bellin, Melena D., MD, Hering, Bernard J., MD, Beilman, Gregory J., MD, FACS, Dunn, Ty B., MD, FACS, Chinnakotla, Srinath, MD, Vickers, Selwyn M., MD, FACS, Bland, Barbara, RN, MS, Balamurugan, A.N., PhD, Freeman, Martin L., MD, Pruett, Timothy L., MD, FACS

“…Background Total pancreatectomy (TP) with intraportal islet autotransplantation (IAT) can relieve pain and preserve β-cell mass in patients with chronic…”
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Potent Induction Immunotherapy Promotes Long‐Term Insulin Independence After Islet Transplantation in Type 1 Diabetes by Bellin, M. D., Barton, F. B., Heitman, A., Harmon, J. V., Kandaswamy, R., Balamurugan, A. N., Sutherland, D. E. R., Alejandro, R., Hering, B. J.

“…The seemingly inexorable decline in insulin independence after islet transplant alone (ITA) has raised concern about its clinical utility. We hypothesized that…”
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Islet Autotransplant Outcomes After Total Pancreatectomy : A Contrast to Islet Allograft Outcomes by SUTHERLAND, David E. R, GRUESSNER, Angelika C, CARLSON, Annelisa M, BLONDET, Juan J, BALAMURUGAN, A. N, REIGSTAD, Katie F, BEILMAN, Gregory J, BERLIN, Melena D, HERING, Bernhard J

“…Islet allografts are currently associated with a high rate of early insulin independence, but after 1 year insulin-independence rates rapidly decline for…”
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Antiapoptotic Actions of Exendin-4 against Hypoxia and Cytokines Are Augmented by CREB by Velmurugan, Kalpana, Balamurugan, A. N, Loganathan, Gopalakrishnan, Ahmad, Aftab, Hering, Bernhard J, Pugazhenthi, Subbiah

“…Islets isolated from cadaveric donor pancreas are functionally viable and can be transplanted in diabetic patients to reduce insulin requirements. This…”
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Long-Term Outcomes of Total Pancreatectomy and Islet Auto Transplantation for Hereditary/Genetic Pancreatitis by Chinnakotla, Srinath, MD, Radosevich, David M., RN, PhD, Dunn, Ty B., MD, FACS, Bellin, Melena D., MD, Freeman, Martin L., MD, Schwarzenberg, Sarah J., MD, Balamurugan, A.N., PhD, Wilhelm, Josh, MS, Bland, Barbara, MS, RN, Vickers, Selwyn M., MD, FACS, Beilman, Gregory J., MD, FACS, Sutherland, David E.R., MD, PhD, Pruett, Timothy L., MD, FACS

“…Background Chronic pancreatitis is a debilitating disease resulting from many causes. The subset with hereditary/genetic pancreatitis (HGP) not only has…”
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A New Enzyme Mixture to Increase the Yield and Transplant Rate of Autologous and Allogeneic Human Islet Products by BALAMURUGAN, A. N, LOGANATHAN, Gopalakrishnan, PAPAS, Klearchos K, MCCARTHY, Robert, SUTHERLAND, David E. R, HERING, Bernhard J, BELLIN, Melena D, WILHELM, Joshua J, HARMON, James, ANAZAWA, Takayuki, SOLTANI, Sajjad M, RADOSEVICH, David M, YUASA, Takeshi, TIWARI, Mukesh

“…The optimal enzyme blend that maximizes human islet yield for transplantation remains to be determined. In this study, we evaluated eight different enzyme…”
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Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells by Srinivasan, Padmanabhan, Thrower, Edwin C, Loganathan, Gopalakrishnan, Balamurugan, A N, Subramanian, Veedamali S, Gorelick, Fred S, Said, Hamid M

“…Thiamin (vitamin B1), a member of the water-soluble family of vitamins, is essential for normal cellular functions; its deficiency results in oxidative stress…”
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Defective Glucagon Secretion During Hypoglycemia After Intrahepatic But Not Nonhepatic Islet Autotransplantation by Bellin, M. D., Parazzoli, S., Oseid, E., Bogachus, L. D., Schuetz, C., Patti, M. E., Dunn, T., Pruett, T., Balamurugan, A. N., Hering, B., Beilman, G., Sutherland, D. E. R., Robertson, R. P.

“…Defective glucagon secretion during hypoglycemia after islet transplantation has been reported in animals and humans with type 1 diabetes. To ascertain whether…”
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Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes by Bellin, M. D., Kandaswamy, R., Parkey, J., Zhang, H.‐J., Liu, B., Ihm, S. H., Ansite, J. D., Witson, J., Bansal‐Pakala, P., Balamurugan, A. N., Papas, K., Sutherland, D. E. R., Moran, A., Hering, B. J.

“…We sought to determine the long‐term outcomes in type 1 diabetic recipients of intraportal alloislet transplants on a modified immunosuppressive protocol. Six…”
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Proposed Thresholds for Pancreatic Tissue Volume for Safe Intraportal Islet Autotransplantation After Total Pancreatectomy by Wilhelm, J. J., Bellin, M. D., Dunn, T. B., Balamurugan, A. N., Pruett, T. L., Radosevich, D. M., Chinnakotla, S., Schwarzenberg, S. J., Freeman, M. L., Hering, B. J., Sutherland, D. E. R., Beilman, G. J.

“…The simple question of how much tissue volume (TV) is really safe to infuse in total pancreatectomy–islet autotransplantation (TP–IAT) for chronic pancreatitis…”
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Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment by BOTTINO, Rita, BALAMURUGAN, A. N, TSE, Hubert, THIRUNAVUKKARASU, C, XINHUI GE, PROFOZICH, Jennifer, MILTON, Martha, ZIEGENFUSS, Audra, TRUCCO, Massimo, PIGANELLI, Jon D

“…Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment Rita Bottino 1 2 , A.N. Balamurugan 3 , Hubert Tse 1 2 , C…”
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Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function by Zhang, Nan, Su, Dongming, Qu, Shen, Tse, Tonia, Bottino, Rita, Balamurugan, A N, Xu, Jing, Bromberg, Jonathan S, Dong, H Henry

“…Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function Nan Zhang 1 , Dongming Su 2 , Shen Qu 2 , Tonia Tse 2 , Rita Bottino 2 ,…”
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Successful human islet isolation and transplantation indicating the importance of class 1 collagenase and collagen degradation activity assay by Balamurugan, A N, Breite, Andrew G, Anazawa, Takayuki, Loganathan, Gopalakrishnan, Wilhelm, Joshua J, Papas, Klearchos K, Dwulet, Francis E, McCarthy, Robert C, Hering, Bernhard J

“…Purified tissue dissociation enzymes (TDEs) are critical to successful human islet isolation required for clinical transplantation, but little is known about…”
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Similar Islet Function in Islet Allotransplant and Autotransplant Recipients, Despite Lower Islet Mass in Autotransplants by BELLIN, Melena D, SUTHERLAND, David E. R, BEILMAN, Gregory J, HONG-MCATEE, Irene, BALAMURUGAN, A. N, HERING, Bernhard J, MORAN, Antoinette

“…Despite high initial rates of insulin independence after islet allotransplant for type 1 diabetes, long-term islet function is suboptimal. Possible…”
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Silicone rubber membrane devices permit islet culture at high density without adverse effects by Avgoustiniatos, Efstathios S, Mueller, Kate R, Scott Iii, William E, Kitzmann, Jennifer P, Suszynski, Thomas M, Perrault, Brian E, Falde, Eric J, Balamurugan, A N, Hering, Bernhard J, Putnam, Charles W, Papas, Klearchos K

“…Conventional culture conditions, such as in T-flasks, require that oxygen diffuse through the medium to reach the islets; in turn, islet surface area density…”
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No Islets Left Behind: Islet Autotransplantation for Surgery-Induced Diabetes by Bellin, Melena D., Balamurugan, A. N., Pruett, Timothy L., Sutherland, David E. R.

“…For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain…”
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Reduction of early graft loss after intraportal porcine islet transplantation in monkeys by ROOD, Pleunie P. M, BOTTINO, Rita, BALAMURUGAN, A. N, SMETANKA, Cindy, AYARES, David, GROTH, Carl-Gustav, MURASE, Noriko, COOPER, David K. C, TRUCCO, Massimo

“…Pig islets constitute a possible resolution to the shortage of human islets for transplantation. After intraportal infusion of porcine islets in primates, many…”
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Trying to Prevent the Clogged Drain: Optimizing the Yield and Function of Portal Vein-Infused Islets by Balamurugan, A. N., Pruett, Timothy L.

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Prediction of Pancreatic Tissue Densities by an Analytical Test Gradient System Before Purification Maximizes Human Islet Recovery for Islet Autotransplantation/Allotransplantation by ANAZAWA, Takayuki, MATSUMOTO, Shuichiro, YONEKAWA, Yukihide, LOGANATHAN, Gopalakrishnan, WILHELM, Joshua J, SOLTANI, Sajjad M, PAPAS, Klearchos K, SUTHERLAND, David E. R, HERING, Bernhard J, BALAMURUGAN, A. N

“…Using standard density gradient (SDG) ranges for human islet purification frequently results in islet loss and transplantation of lower islet mass. Measuring…”
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Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice by Casu, A, Bottino, R, Balamurugan, A. N, Hara, H, van der Windt, D. J, Campanile, N, Smetanka, C, Cooper, D. K. C, Trucco, M

“…Aims/hypothesis Attempts to use an alternative source of islets to restore glucose homeostasis in diabetic patients require preclinical islet…”
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