Search Results - "BAL DE KIER JOFFE, Elisa"

The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin by Pontiggia, Osvaldo, Sampayo, Rocio, Raffo, Diego, Motter, Andrea, Xu, Ren, Bissell, Mina J., de Kier Joffé, Elisa Bal, Simian, Marina

“…Tamoxifen resistance has been largely attributed to genetic alterations in the epithelial tumor cells themselves, such as overexpression of HER-2/Neu. However,…”
Get full text

Progestin Effects on Breast Cancer Cell Proliferation, Proteases Activation, and in Vivo Development of Metastatic Phenotype All Depend on Progesterone Receptor Capacity to Activate Cytoplasmic Signaling Pathways by Carnevale, Romina P, Proietti, Cecilia J, Salatino, Mariana, Urtreger, Alejandro, Peluffo, Guillermo, Edwards, Dean P, Boonyaratanakornkit, Viroj, Charreau, Eduardo H, de Kier Joffé, Elisa Bal, Schillaci, Roxana, Elizalde, Patricia V

“…Accumulating evidence indicates that progestins are involved in controlling mammary gland tumorigenesis. Here, we assessed the molecular mechanisms of…”
Get full text

Pharmacological Strategies in Lung Cancer-Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness by Chacon-Cabrera, Alba, Fermoselle, Clara, Urtreger, Alejandro J., Mateu-Jimenez, Mercè, Diament, Miriam J., de Kier Joffé, Elisa D. Bal, Sandri, Marco, Barreiro, Esther

“…ABSTRACT Cachexia is a relevant comorbid condition of chronic diseases including cancer. Inflammation, oxidative stress, autophagy, ubiquitin–proteasome…”
Get full text

Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs by Díaz Bessone, María Ines, Berardi, Damian E., Campodónico, Paola B., Todaro, Laura B., Lothstein, Leonard, Bal de Kier Joffé, Elisa D., Urtreger, Alejandro J.

“…Doxorubicin is an anti-tumor antibiotic widely used in the management of cancer patients. Its main mechanism of action involves the generation of DNA damage…”
Get full text

Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice by Fermoselle, Clara, García‐Arumí, Elena, Puig‐Vilanova, Ester, Andreu, Antoni L., Urtreger, Alejandro J., de Kier Joffé, Elisa D. Bal, Tejedor, Alberto, Puente‐Maestu, Luís, Barreiro, Esther

“…New Findings •  What is the central question of this study? We explored whether experimental cancer‐induced cachexia may alter mitochondrial respiratory chain…”
Get full text

The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines by Cirigliano, Stéfano M, Díaz Bessone, María I, Berardi, Damián E, Flumian, Carolina, Bal de Kier Joffé, Elisa D, Perea, Silvio E, Farina, Hernán G, Todaro, Laura B, Urtreger, Alejandro J

“…Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide. Up to 80% of cancer patients are classified as…”
Get full text

Clinical relevance of galectin-1 expression in non-small cell lung cancer patients by Carlini, María José, Roitman, Pablo, Nuñez, Myriam, Pallotta, María Guadalupe, Boggio, Gastón, Smith, David, Salatino, Mariana, Joffé, Elisa D. Bal de Kier, Rabinovich, Gabriel A, Puricelli, Lydia I

“…Abstract Background Identification of biomarkers in lung cancer, a leading cause of cancer-related mortality, has a meaningful clinical relevance in the quest…”
Get full text

Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria by Galli, Soledad, Antico Arciuch, Valeria Gabriela, Poderoso, Cecilia, Converso, Daniela Paola, Zhou, Qiongqiong, Bal de Kier Joffé, Elisa, Cadenas, Enrique, Boczkowski, Jorge, Carreras, María Cecilia, Poderoso, Juan José

“…Mitochondria are major cellular sources of hydrogen peroxide (H(2)O(2)), the production of which is modulated by oxygen availability and the mitochondrial…”
Get full text

Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells by RAFFO, DIEGO, PONTIGGIA, OSVALDO, DE KIER JOFFÉ, ELISA BAL, SIMIAN, MARINA

“…Estrogens and tamoxifen do not only exert their effects at the genomic level, but also play a role at the cell membrane activating downstream signaling…”
Get full text

Is the epithelial-to-mesenchymal transition clinically relevant for the cancer patient? by Krasnapolski, Martin A, Todaro, Laura B, de Kier Joffé, Elisa Bal

“…Epithelial-to-mesenchymal transition (EMT) is a transdifferentiation process by which a fully differentiated epithelial cell acquires mesenchymal traits, and…”
Get more information

The Immune System As a New Possible Cell Target for AFP 464 in a Spontaneous Mammary Cancer Mouse Model by Callero, Mariana A., Rodriguez, Cristina E., Sólimo, Aldana, Bal de Kier Joffé, Elisa, Loaiza Perez, Andrea I.

“…ABSTRACT Aminoflavone (AFP 464, NSC 710464), an antitumor agent which recently entered phase II clinical trials, acts against estrogen‐positive breast cancer…”
Get full text

Pharmacological Approaches in an Experimental Model of Non-Small Cell Lung Cancer: Effects on Tumor Biology by Mateu-Jimenez, Mercè, Fermoselle, Clara, Rojo, Federico, Mateu, Javier, Peña, Raúl, Urtreger, Alejandro J, Diament, Miriam J, Joffé, Elisa D Bal de Kier, Pijuan, Lara, Herreros, Antonio García de, Barreiro, Esther

“…Lung cancer (LC) remains the leading cause of cancer mortality worldwide, and non-small cell LC (NSCLC) represents 80% of all LC. Oxidative stress and…”
Get more information

Contribution of individual PKC isoforms to breast cancer progression by Urtreger, Alejandro J., Kazanietz, Marcelo G., Bal de Kier Joffé, Elisa D.

“…The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied in cancer since their discovery as major receptors for the…”
Get full text

Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum by Gompel, Marie, Leost, Maryse, De Kier Joffe, Elisa Bal, Puricelli, Lydia, Franco, Laura Hernandez, Palermo, Jorge, Meijer, Laurent

“…Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia…”
Get full text

Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture by Rodríguez, Cristina E., Berardi, Damian E., Abrigo, Marianela, Todaro, Laura B., Bal de Kier Joffé, Elisa D., Fiszman, Gabriel L.

“…Breast cancer human cells culture as spheroids develop autophagy and apoptosis, which promotes Trastuzumab resistance in HER2 overexpressing cells. Our aim was…”
Get full text

PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy by Berardi, Damián E., Flumian, Carolina, Rodriguez, Cristina E., Díaz Bessone, María I., Cirigliano, Stefano M., Bal de Kier Joffé, Elisa D., Fiszman, Gabriel L., Urtreger, Alejandro J., Todaro, Laura B.

“…ABSTRACT Protein kinase C (PKC) is a family of serine/threonine kinases that regulate diverse cellular functions including cell death, proliferation, and…”
Get full text

Involvement of protein kinase C α and δ activities on the induction of the retinoic acid system in mammary cancer cells by Berardi, Damián E., Bessone, María I. Díaz, Motter, Andrea, Bal de Kier Joffé, Elisa D., Urtreger, Alejandro J., Todaro, Laura B.

“…It has been established that retinoids exert some of their effects on cell differentiation and malignant phenotype reversion through the interaction with…”
Get full text

Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation by Stigliano, Ivan, Puricelli, Lydia, Filmus, Jorge, Sogayar, Mari Cleide, Bal de Kier Joffé, Elisa, Peters, María Giselle

“…Glypican-3 (GPC3) is a proteoglycan involved in migration, proliferation and cell survival modulation in several tissues. There are many reports demonstrating…”
Get full text

Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments by Blidner, Ada G, Salatino, Mariana, Mascanfroni, Ivan D, Diament, Miriam J, Bal de Kier Joffé, Elisa, Jasnis, Maria A, Klein, Slobodanka M, Rabinovich, Gabriel A

“…Myeloid-derived suppressor cells (MDSCs) are key regulatory cells that control inflammation and promote tumor-immune escape. To date, no specific…”
Get full text

CD44 expression in human gliomas by Ranuncolo, Stella Maris, Ladeda, Virginia, Specterman, Sergio, Varela, Mirta, Lastiri, José, Morandi, Ana, Matos, Elena, De Kier Joffe, Elisa Bal, Puricelli, Lydia, Pallotta, María Guadalupe

“…Background and Objectives Glioma invasiveness involves the attachment of tumor cells to the brain extracellular matrix, rich in hyaluronic acid (HA). CD44, the…”
Get full text