Search Results - "BAKER, Nicola"

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story by Baker, Nicola, de Koning, Harry P, Mäser, Pascal, Horn, David

“…Melarsoprol and pentamidine represent the two main classes of drugs, the arsenicals and diamidines, historically used to treat the diseases caused by African…”
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High-throughput decoding of antitrypanosomal drug efficacy and resistance by Alsford, Sam, Eckert, Sabine, Baker, Nicola, Glover, Lucy, Sanchez-Flores, Alejandro, Leung, Ka Fai, Turner, Daniel J., Field, Mark C., Berriman, Matthew, Horn, David

“…Five current human African trypanosomiasis drugs are used for genome-scale RNA interference target sequencing screens in Trypanosoma brucei , and reveal the…”
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Insights into antitrypanosomal drug mode-of-action from cytology-based profiling by Thomas, James A, Baker, Nicola, Hutchinson, Sebastian, Dominicus, Caia, Trenaman, Anna, Glover, Lucy, Alsford, Sam, Horn, David

“…Chemotherapy continues to have a major impact on reducing the burden of disease caused by trypanosomatids. Unfortunately though, the mode-of-action (MoA) of…”
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Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity by Jeacock, Laura, Baker, Nicola, Wiedemar, Natalie, Mäser, Pascal, Horn, David

“…Aquaglyceroporins (AQPs) transport water and glycerol and play important roles in drug-uptake in pathogenic trypanosomatids. For example, AQP2 in the…”
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Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes by Baker, Nicola, Glover, Lucy, Munday, Jane C, Aguinaga Andrés, David, Barrett, Michael P, de Koning, Harry P, Horn, David

“…African trypanosomes cause sleeping sickness in humans, a disease that is typically fatal without chemotherapy. Unfortunately, drug resistance is common and…”
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Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2 by Song, Jie, Baker, Nicola, Rothert, Monja, Henke, Björn, Jeacock, Laura, Horn, David, Beitz, Eric

“…The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the…”
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Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes by Baker, Nicola, Graham Hamilton, Jonathan M. Wilkes, Sebastian Hutchinson, Michael P. Barrett, David Horn

“…Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA…”
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Downstream passage of silver European eel (Anguilla anguilla) at a pumping station with a gravity sluice by Baker, Nicola J., Wright, Rosalind M., Cowx, Ian G., Murphy, Leona A., Bolland, Jonathan D.

“…The European eel (Anguilla anguilla (L.)) is critically endangered after a multi-decadal decline. Anthropogenic disruption to downstream migration, including…”
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Evolutionary analysis of cellular reduction and anaerobicity in the hyper-prevalent gut microbe Blastocystis by Záhonová, Kristína, Low, Ross S., Warren, Christopher J., Cantoni, Diego, Herman, Emily K., Yiangou, Lyto, Ribeiro, Cláudia A., Phanprasert, Yasinee, Brown, Ian R., Rueckert, Sonja, Baker, Nicola L., Tachezy, Jan, Betts, Emma L., Gentekaki, Eleni, van der Giezen, Mark, Clark, C. Graham, Jackson, Andrew P., Dacks, Joel B., Tsaousis, Anastasios D.

“…Blastocystis is the most prevalent microbial eukaryote in the human and animal gut, yet its role as commensal or parasite is still under debate. Blastocystis…”
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An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy by STOKES, Neil R, BAKER, Nicola, MITCHELL, Jeffrey P, NAYAL, Narendra, YADAV, Anju, SRIVASTAVA, Anil, HAYDON, David J, BENNETT, James M, BERRY, Joanne, COLLINS, Ian, CZAPLEWSKI, Lloyd G, LOGAN, Alastair, MACDONALD, Rebecca, MACLEOD, Leanne, PEASLEY, Hilary

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ by Stokes, Neil R, Baker, Nicola, Bennett, James M, Chauhan, Pramod K, Collins, Ian, Davies, David T, Gavade, Maruti, Kumar, Dushyant, Lancett, Paul, Macdonald, Rebecca, Macleod, Leanne, Mahajan, Anu, Mitchell, Jeffrey P, Nayal, Narendra, Nayal, Yashodanand Nandan, Pitt, Gary R W, Singh, Mahipal, Yadav, Anju, Srivastava, Anil, Czaplewski, Lloyd G, Haydon, David J

“…The design, synthesis and structure-activity relationships of a series of oxazole-benzamide inhibitors of the essential bacterial cell division protein FtsZ…”
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Does cardiac rehabilitation for people with stroke in the sub-acute phase of recovery lead to physical behaviour change? Results from compositional analysis of accelerometry-derived data by Orme, Mark W., Clague-Baker, Nicola J., Richardson, Matthew, Drewry, Sophie, Robinson, Thompson G., Singh, Sally J.

“…Does adapted cardiac rehabilitation (CR) improve the physical behaviours of people with mild-to-moderate stroke in the sub-acute recovery phase using a…”
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Direct and indirect impacts of pumping station operation on downstream migration of critically endangered European eel by Bolland, Jonathan D., Murphy, Leona A., Stanford, Robert J., Angelopoulos, Natalie V., Baker, Nicola J., Wright, Rosalind M., Reeds, Jake D., Cowx, Ian G.

“…Downstream passage of European eel Anguilla anguilla (L.) in catchments with pump(s) for water level management is a major concern. Catchment‐wide acoustic…”
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Emerging Concepts in Pediatric Emergency Radiology by Baker, Nicola, MD, Woolridge, Dale, MD, PhD

“…Radiologic studies are a vital component in the workup and diagnosis of disease. An appropriate radiographic study will accurately rule in or rule out disease…”
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Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates by Graf, Fabrice E., Baker, Nicola, Munday, Jane C., de Koning, Harry P., Horn, David, Mäser, Pascal

“…•Expression of AQP2 restores drug susceptibility in a resistant Trypanosoma brucei gambiense isolate.•The AQP2/3 chimera from the resistant isolate does not…”
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Enhanced Photoresponse in Solid-State Excitonic Solar Cells via Resonant Energy Transfer and Cascaded Charge Transfer from a Secondary Absorber by Driscoll, Kristina, Fang, Junfeng, Humphry-Baker, Nicola, Torres, Tomás, Huck, Wilhelm T. S, Snaith, Henry J, Friend, Richard H

“…We present a spiro-linked molecule 2,2′,7,7′-tetrakis(3-hexyl-5-(7-(4-hexylthiophen-2-yl)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)-9,9′-spirobifluorene…”
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Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6 by Baker, Nicola, Alsford, Sam, Horn, David

“…Genome-scale RNA interference (RNAi) library screens in bloodstream-form Trypanosoma brucei, using nifurtimox and benznidazole, revealed type I nitroreductase,…”
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Attitudes of cardiac rehabilitation and stroke teams towards integration of stroke survivors into adapted cardiac rehabilitation: A focus group study by Clague-Baker, Nicola, Robinson, Thompson, Hagenberg, Annegret, Drewry, Sophie, Singh, Sally

“…Objective To explore the attitudes and beliefs of cardiac rehabilitation and stroke teams towards adapted cardiac rehabilitation, and the broader topics of…”
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Evaluating the impact of hydropower on downstream migrating anguillid eels: Catchment-wide and fine-scale approaches to identify cost-effective solutions by Baker, Nicola Joanne, Boubée, Jacques, Lokman, P. Mark, Bolland, Jonathan David

“…Hydropower is an increasingly popular source of renewable and ‘green’ (in terms of emissions) energy, but reduced longitudinal connectivity and diverting flow…”
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Comparison of attraction, entrance and passage of downstream migrant American eels (Anguilla rostrata) through airlift and siphon deep entrance bypass systems by Baker, Nicola, Haro, Alex, Watten, Barnaby, Noreika, John, Bolland, Jonathan D.

“…Downstream migrating anguillid eels face many barriers including turbines and pumps at impoundments for water abstraction, power generation and water level…”
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