Search Results - "BAINBRIDGE, J. W. B"

Gene therapy progress and prospects: the eye by BAINBRIDGE, J. W. B, TAN, M. H, ALI, R. R

“…The eye has unique advantages as a target organ for gene therapy of both inherited and acquired ocular disorders and offers a valuable model system for gene…”
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In situ regeneration of retinal pigment epithelium by gene transfer of E2F2: a potential strategy for treatment of macular degenerations by Kampik, D, Basche, M, Luhmann, U F O, Nishiguchi, K M, Williams, J A E, Greenwood, J, Moss, S E, Han, H, Azam, S, Duran, Y, Robbie, S J, Bainbridge, J W B, Larkin, D F, Smith, A J, Ali, R R

“…The retinal pigment epithelium (RPE) interacts closely with photoreceptors to maintain visual function. In degenerative diseases such as Stargardt disease and…”
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Correction: Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65 by Georgiadis, A., Duran, Y., Ribeiro, J., Abelleira-Hervas, L., Robbie, S. J., Sünkel-Laing, B., Fourali, S., Gonzalez-Cordero, A., Cristante, E., Michaelides, M., Bainbridge, J. W. B., Smith, A. J., Ali, R. R.

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Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65 by Georgiadis, A, Duran, Y, Ribeiro, J, Abelleira-Hervas, L, Robbie, S J, Sünkel-Laing, B, Fourali, S, Gonzalez-Cordero, A, Cristante, E, Michaelides, M, Bainbridge, J W B, Smith, A J, Ali, R R

“…Leber congenital amaurosis is a group of inherited retinal dystrophies that cause severe sight impairment in childhood; RPE65-deficiency causes impaired rod…”
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Gene supplementation therapy for recessive forms of inherited retinal dystrophies by Smith, A J, Bainbridge, J W B, Ali, R R

“…Over the last decade, gene supplementation therapy for inherited retinal degeneration has come of age. Early proof-of-concept studies in animal models of…”
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RPE65 gene therapy slows cone loss in Rpe65-deficient dogs by Mowat, F M, Breuwer, A R, Bartoe, J T, Annear, M J, Zhang, Z, Smith, A J, Bainbridge, J W B, Petersen-Jones, S M, Ali, R R

“…Recent clinical trials of retinal pigment epithelium gene ( RPE65 ) supplementation therapy in Leber congenital amaurosis type 2 patients have demonstrated…”
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AAV-mediated knockdown of Peripherin-2 in vivo using miRNA-based hairpins by Georgiadis, A, Tschernutter, M, Bainbridge, J W B, Robbie, S J, McIntosh, J, Nathwani, A C, Smith, A J, Ali, R R

“…Gene therapy for inherited retinal degeneration in which expression of a mutant allele has a gain-of-function effect on photoreceptor cells is likely to depend…”
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Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy by TSCHERNUTTER, M, SCHLICHTENBREDE, F. C, HOWE, S, BALAGGAN, K. S, MUNRO, P. M, BAINBRIDGE, J. W. B, THRASHER, A. J, SMITH, A. J, ALI, R. R

“…The Royal College of Surgeons (RCS) rat is a well-characterized model of autosomal recessive retinitis pigmentosa (RP) due to a defect in the retinal pigment…”
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Absence of ocular malignant transformation after sub-retinal delivery of rAAV2/2 or integrating lentiviral vectors in p53-deficient mice by Balaggan, K S, Duran, Y, Georgiadis, A, Thaung, C, Barker, S E, Buch, P K, MacNeil, A, Robbie, S, Bainbridge, J W B, Smith, A J, Ali, R R

“…Insertional mutagenesis following gene therapy with gammaretroviral vectors can cause the development of lymphoproliferation in children with X-linked severe…”
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EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV by BALAGGAN, K. S, BINLEY, K, BAINBRIDGE, T. W. B, NAVLOR, S, ALI, R. R, ESAPA, M, MACLAREN, R. E, IQBALL, S, DURAN, Y, PEARSON, R. A, KAN, O, BARKER, S. E, SMITH, A. T

“…We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin…”
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Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis by Trittibach, P, Barker, S E, Broderick, C A, Natkunarajah, M, Duran, Y, Robbie, S J, Bainbridge, J W B, Smith, A J, Sarra, G-M, Dick, A D, Ali, R R

“…Uveitis is a sight threatening inflammatory disorder that remains a significant cause of visual loss. We investigated lentiviral gene delivery of interleukin 1…”
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Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration by SCHLICHTENBREDE, F. C, MACNEIL, A, BAINBRIDGE, J. W. B, TSCHERNUTTER, M, THRASHER, A. J, SMITH, A. J, ALI, R. R

“…Intraocular delivery of a variety of neurotrophic factors has been widely investigated as a potential treatment for retinal dystrophy (RD). The most commonly…”
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Stable rAAV-mediated transduction of rod and cone photoreceptors in the canine retina by BAINBRIDGE, J. W. B, MISTRY, A, CHARTERIS, D, THRASHER, A. J, SARGAN, D, ALI, R. R, SCHLICHTENBREDE, F. C, SMITH, A, BRODERICK, C, DE ALWIS, M, GEORGIADIS, A, TAYLOR, P. M, SQUIRES, M, SETHI, C

“…Recombinant adeno-associated virus (rAAV) vectors are attractive candidates for the treatment of inherited and acquired retinal disease. Although rAAV vectors…”
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Hypoxia-regulated transgene expression in experimental retinal and choroidal neovascularization by BAINBRIDGE, J. W. B, MISTRY, A, BINLEY, K, DE ALWIS, M, THRASHER, A. J, NAYLOR, S, ALI, R. R

“…Recombinant AAV vectors mediate efficient and sustained transgene expression in retinal tissues and offer a powerful approach to the local, sustained delivery…”
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Correction: Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65 by Georgiadis, A., Duran, Y., Ribeiro, J., Abelleira-Hervas, L., Robbie, S. J., Sünkel-Laing, B., Fourali, S., Gonzalez-Cordero, A., Cristante, E., Michaelides, M., Bainbridge, J. W. B., Smith, A. J., Ali, R. R.

“…The authors originally published this article under the incorrect license type; this has now been corrected and is published under the CC-BY license…”
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Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1 by BAINBRIDGE, J. W. B, MISTRY, A, DE ALWIS, M, PALEOLOG, E, BAKER, A, THRASHER, A. J, ALI, R. R

“…Retinal angiogenesis is a central feature of the leading causes of blindness. Current treatments for these conditions are of limited efficacy and cause…”
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Stable and efficient intraocular gene transfer using pseudotyped EIAV lentiviral vectors by Balaggan, K. S., Binley, K., Esapa, M., Iqball, S., Askham, Z., Kan, O., Tschernutter, M., Bainbridge, J. W. B., Naylor, S., Ali, R. R.

“…Background We have developed minimal non‐primate lentiviral vectors based on the equine infectious anaemia virus (EIAV). We evaluated the in vivo expression…”
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Prospects for gene therapy of inherited retinal disease by Bainbridge, J W B

“…Gene-based therapies offer the means to address gene defects responsible for inherited retinal disorders. A number of studies in experimental and preclinical…”
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Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis by Bainbridge, James W.B, Mehat, Manjit S, Sundaram, Venki, Robbie, Scott J, Barker, Susie E, Ripamonti, Caterina, Georgiadis, Anastasios, Mowat, Freya M, Beattie, Stuart G, Gardner, Peter J, Feathers, Kecia L, Luong, Vy A, Yzer, Suzanne, Balaggan, Kamaljit, Viswanathan, Ananth, de Ravel, Thomy J.L, Casteels, Ingele, Holder, Graham E, Tyler, Nick, Fitzke, Fred W, Weleber, Richard G, Nardini, Marko, Moore, Anthony T, Thompson, Debra A, Petersen-Jones, Simon M, Michaelides, Michel, van den Born, L. Ingeborgh, Stockman, Andrew, Smith, Alexander J, Rubin, Gary, Ali, Robin R

“…Long-term follow-up of 12 persons with Leber's congenital amaurosis treated with gene therapy showed that about half of them had improvements in retinal…”
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Intraocular lens implants and risk of endophthalmitis by Bainbridge, J W B, Teimory, M, Tabandeh, H, Kirwan, J F, Dalton, R, Reid, F, Rostron, C K

“…AIM To investigate the possible association between the use of three piece foldable silicone polypropylene (SPP) intraocular lenses (IOLs) and an increased…”
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