Search Results - "BAHINSKI, A"

Human organs-on-chips by Bahinski, A.

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Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel by SHAOQING TANG, MIKALA, G, BAHINSKI, A, YATANI, A, VARADI, G, SCHWARTZ, A

“…A highly conserved position of negatively charged amino acids is present in the SS2 segments of the S5-S6 linker regions among calcium channels. We report here…”
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Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels by Yang, I C, Scherz, M W, Bahinski, A, Bennett, P B, Murray, K T

“…Selective inhibitors of the slow component of the cardiac delayed rectifier K(+) current, I(Ks), are of interest as novel class III antiarrhythmic agents and…”
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Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel by Malinowska, D H, Kupert, E Y, Bahinski, A, Sherry, A M, Cuppoletti, J

“…cDNA encoding a Cl- channel was isolated from a rabbit gastric library, sequenced, and expressed in Xenopus oocytes. The predicted protein (898 amino acids,…”
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Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade by Chaudhary, Khuram W, O'Neal, Janet M, Mo, Zun-Li, Fermini, Bernard, Gallavan, Robert H, Bahinski, Anthony

“…Inhibition of the delayed-rectifier potassium channel current, human ether-a-go-go (hERG), by pharmaceutical agents can lead to acquired long QT syndrome and…”
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Robotic fluidic coupling and interrogation of multiple vascularized organ chips by Novak, Richard, Ingram, Miles, Marquez, Susan, Das, Debarun, Delahanty, Aaron, Herland, Anna, Maoz, Ben M., Jeanty, Sauveur S. F., Somayaji, Mahadevabharath R., Burt, Morgan, Calamari, Elizabeth, Chalkiadaki, Angeliki, Cho, Alexander, Choe, Youngjae, Chou, David Benson, Cronce, Michael, Dauth, Stephanie, Divic, Toni, Fernandez-Alcon, Jose, Ferrante, Thomas, Ferrier, John, FitzGerald, Edward A., Fleming, Rachel, Jalili-Firoozinezhad, Sasan, Grevesse, Thomas, Goss, Josue A., Hamkins-Indik, Tiama, Henry, Olivier, Hinojosa, Chris, Huffstater, Tessa, Jang, Kyung-Jin, Kujala, Ville, Leng, Lian, Mannix, Robert, Milton, Yuka, Nawroth, Janna, Nestor, Bret A., Ng, Carlos F., O’Connor, Blakely, Park, Tae-Eun, Sanchez, Henry, Sliz, Josiah, Sontheimer-Phelps, Alexandra, Swenor, Ben, Thompson, Guy, Touloumes, George J., Tranchemontagne, Zachary, Wen, Norman, Yadid, Moran, Bahinski, Anthony, Hamilton, Geraldine A., Levner, Daniel, Levy, Oren, Przekwas, Andrzej, Prantil-Baun, Rachelle, Parker, Kevin K., Ingber, Donald E.

“…Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular…”
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Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing by Marx, Uwe, Andersson, Tommy B, Bahinski, Anthony, Beilmann, Mario, Beken, Sonja, Cassee, Flemming R, Cirit, Murat, Daneshian, Mardas, Fitzpatrick, Susan, Frey, Olivier, Gaertner, Claudia, Giese, Christoph, Griffith, Linda, Hartung, Thomas, Heringa, Minne B, Hoeng, Julia, de Jong, Wim H, Kojima, Hajime, Kuehnl, Jochen, Leist, Marcel, Luch, Andreas, Maschmeyer, Ilka, Sakharov, Dmitry, Sips, Adrienne J A M, Steger-Hartmann, Thomas, Tagle, Danilo A, Tonevitsky, Alexander, Tralau, Tewes, Tsyb, Sergej, van de Stolpe, Anja, Vandebriel, Rob, Vulto, Paul, Wang, Jufeng, Wiest, Joachim, Rodenburg, Marleen, Roth, Adrian

“…The recent advent of microphysiological systems - microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation…”
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Block of Transient Outward-Type Cloned Cardiac K+ Channel Currents by Quinidine by Yatani, Atsuko, Wakamori, Minoru, Mikala, Gabor, Bahinski, Anthony

“…The antiarrhythmic drug quinidine has been shown to block several types of K channel currents in cardiac preparations including the transient outward current…”
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Synchronous Occurrence of Spontaneous Localized Calcium Release From the Sarcoplasmic Reticulum Generates Action Potentials in Rat Cardiac Ventricular Myocytes at Normal Resting Membrane Potential by Capogrossi, Maurizio C, Houser, Steven R, Bahinski, Anthony, Lakatta, Edward G

“…Under certain conditions, spontaneous release of Ca from the sarcoplasmic reticulum occurs in resting mammalian myocardium. In single rat ventricular myocytes,…”
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Potassium Translocation by the Na+/K+ Pump is Voltage Insensitive by Bahinski, Anthony, Nakao, Masakazu, Gadsby, David C.

“…The voltage dependence of steady and transient changes in Na+/K+ pump current, in response to step changes in membrane potential, was investigated in guinea…”
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Cardiovascular disease and arrhythmias: unique risks in women by Malloy, K J, Bahinski, A

“…Women have higher risks for symptomatic arrhythmias and sudden death than men. A significantly higher resting heart rate and longer QT interval on…”
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C31 EXPERIMENTAL ASTHMA THERAPIES: A Microfluidic Small Airway-On-Chip Enables Analysis Of Human Lung Inflammation And Therapeutic Responses In Vitro by Villenave, R, Benam, K, Lucchesi, C, Varone, A, Hubeau, C, Lee, H, Alves, S, Salmon, M, Ferrante, T, Weaver, J, Bahinski, A, Hamilton, G, Ingber, D E

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C21 OMICS IN LUNG DISEASE: Human Small Airway-On-A-Chip: A Novel Microphysiological System To Model Lung Inflammation, Accelerate Drug Development And Enable Inhalational Toxico-Analysis by Benam, K, Novak, R, Villenave, R, Lucchesi, C, Hubeau, C, Nawroth, J, Hirano-Kobayashi, M, Ferrante, T C, Choe, Y, Prantil-Baun, R, Weaver, J C, Hamilton, G A, Bahinski, A, Parker, K K, Ingber, D E

“…Importantly, by connecting the small airway chip to a custom-designed electromechanical instrument that 'breathes' whole cigarette smoke in and out of the chip…”
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Acidosis facilitates spontaneous sarcoplasmic reticulum Ca2+ release in rat myocardium by ORCHARD, C. H, HOUSER, S. R, KORT, A. A, BAHINSKI, A, CAPOGROSSI, M. C, LAKATTA, E. G

“…Previous studies have shown that acidosis increases myoplasmic [Ca2+] (Cai). We have investigated whether this facilitates spontaneous sarcoplasmic reticulum…”
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HL-1 Cells: A Cardiac Muscle Cell Line that Contracts and Retains Phenotypic Characteristics of the Adult Cardiomyocyte by Claycomb, William C., Lanson, Nicholas A., Stallworth, Beverly S., Egeland, Daniel B., Delcarpio, Joseph B., Bahinski, Anthony, Izzo, Nicholas J.

“…We have derived a cardiac muscle cell line, designated HL-1, from the AT-1 mouse atrial cardiomyocyte tumor lineage. HL-1 cells can be serially passaged, yet…”
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Passive membrane properties of isolated feline ventricular myocytes by Houser, S R, Bahinski, A, Silver, L H

“…Membrane properties of adult mammalian cardiac muscle are difficult to define mainly because of experimental complications arising from complex packing of…”
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Embryonic Stem Cells in Predictive Cardiotoxicity: Laser Capture Microscopy Enables Assay Development by Chaudhary, Khuram W., Barrezueta, Nestor X., Bauchmann, Mary B., Milici, Anthony J., Beckius, Gretchen, Stedman, Donald B., Hambor, John E., Blake, William L., McNeish, John D., Bahinski, Anthony, Cezar, Gabriela Gebrin

“…Embryonic stem (ES) cells offer unprecedented opportunities for in vitro drug discovery and safety assessment of compounds. Cardiomyocytes derived from ES…”
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Hypertrophy without contractile dysfunction after reversal of pressure overload in the cat by Wisenbaugh, T, Allen, P, Cooper, 4th, G, O'Connor, W N, Mezaros, L, Streter, F, Bahinski, A, Houser, S, Spann, J F

“…To determine whether a causal relationship exists between the myocardial hypertrophy and the deficits in myosin ATPase activity and contractile function that…”
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Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes by Bahinski, Anthony, Nairn, Angus C, Greengard, Paul, Gadsby, David C

“…In heart cells, cyclic AMP-dependent protein kinase (PKA) regulates calcium- and potassium-ion current by phosphorylating the ion channels or closely…”
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Molecular localization of regions in the L-type calcium channel critical for dihydropyridine action by Tang, S, Yatani, A, Bahinski, A, Mori, Y, Schwartz, A

“…Sensitivity to dihydropyridines (DHPs) is a distinct characteristic that differentiates L-type Ca2+ channels from T-, N-, and P-type Ca2+ channels. To identify…”
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