Search Results - "BAGBY, Grover"

Recent advances in understanding hematopoiesis in Fanconi Anemia [version 1; peer review: 4 approved] by Bagby, Grover

“…Fanconi anemia is an inherited disease characterized by genomic instability, hypersensitivity to DNA cross-linking agents, bone marrow failure, short stature,…”
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Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia by Carey, Alyssa, Edwards, David K., Eide, Christopher A., Newell, Laura, Traer, Elie, Medeiros, Bruno C., Pollyea, Daniel A., Deininger, Michael W., Collins, Robert H., Tyner, Jeffrey W., Druker, Brian J., Bagby, Grover C., McWeeney, Shannon K., Agarwal, Anupriya

“…Secreted proteins in the bone marrow microenvironment play critical roles in acute myeloid leukemia (AML). Through an ex vivo functional screen of 94…”
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Graft‐versus‐host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations by Newell, Laura F., Dunlap, Jennifer, Gatter, Ken, Bagby, Grover C., Press, Richard D., Cook, Rachel J., Fletcher, Luke, Leonard, Jessica T., Leong, Kelli M., Bubalo, Joseph S., Olyaei, Ali, Deloughery, Thomas G., Maziarz, Richard T., Maynard, Erin, Orloff, Susan L., Enestvedt, C. Kristian

“…Graft‐versus‐host disease after liver transplantation (LT‐GVHD) is rare, frequently fatal, and associated with bone marrow failure (BMF), cytopenias, and…”
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Fanconi Anemia by Bagby, Grover C., Alter, Blanche P.

“…Fanconi anemia (FA) is a rare hereditary disease characterized by bone marrow failure and developmental anomalies; a high incidence of myelodysplasia (MDS),…”
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Multifunctional Fanconi proteins, inflammation and the Fanconi phenotype by Bagby, Grover C.

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Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages by Garbati, Michael R., Hays, Laura E., Rathbun, R. Keaney, Jillette, Nathaniel, Chin, Kathy, Al‐Dhalimy, Muhsen, Agarwal, Anupriya, Newell, Amy E. Hanlon, Olson, Susan B., Bagby, Grover C.

“…TLR‐activated FANCC‐deficient macrophages overproduce inflammatory cytokines and sustain DNA damage, where induced DNA damage is not required to sustain…”
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Genetic basis of Fanconi anemia by Bagby, Grover C

“…Fanconi anemia is a rare autosomal recessive disease characterized by bone marrow failure, developmental anomalies, a high incidence of myelodysplasia and…”
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Fancd2−/− mice have hematopoietic defects that can be partially corrected by resveratrol by Zhang, Qing-Shuo, Marquez-Loza, Laura, Eaton, Laura, Duncan, Andrew W., Goldman, Devorah C., Anur, Praveen, Watanabe-Smith, Kevin, Rathbun, R. Keaney, Fleming, William H., Bagby, Grover C., Grompe, Markus

“…Progressive bone marrow failure is a major cause of morbidity and mortality in human Fanconi Anemia patients. In an effort to develop a Fanconi Anemia murine…”
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PlGF enhances TLR‐dependent inflammatory responses in human mononuclear phagocytes by Newell, Laura F., Holtan, Shernan G., Yates, Jane E., Pereira, Leonardo, Tyner, Jeffrey W., Burd, Irina, Bagby, Grover C.

“…Problem Levels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus‐induced morbidity…”
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FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages by Garbati, Michael R., Hays, Laura E., Keeble, Winifred, Yates, Jane E., Rathbun, R. Keaney, Bagby, Grover C.

“…Hematopoietic stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersensitive to inflammatory cytokines. One of…”
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Mutant calreticulin‐expressing cells induce monocyte hyperreactivity through a paracrine mechanism by Garbati, Michael R., Welgan, Catherine A., Landefeld, Sally H., Newell, Laura F., Agarwal, Anupriya, Dunlap, Jennifer B., Chourasia, Tapan K., Lee, Hyunjung, Elferich, Johannes, Traer, Elie, Rattray, Rogan, Cascio, Michael J., Press, Richard D., Bagby, Grover C., Tyner, Jeffrey W., Druker, Brian J., Dao, Kim‐Hien T.

“…Mutations in the calreticulin gene (CALR) were recently identified in approximately 70–80% of patients with JAK2‐V617F‐negative essential thrombocytosis and…”
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Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling by Zhang, Qing-Shuo, Benedetti, Eric, Deater, Matthew, Schubert, Kathryn, Major, Angela, Pelz, Carl, Impey, Soren, Marquez-Loza, Laura, Rathbun, R Keaney, Kato, Shigeaki, Bagby, Grover C, Grompe, Markus

“…Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely…”
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TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells by Li, June, Sejas, Daniel P, Zhang, Xiaoling, Qiu, Yuhui, Nattamai, Kalpana J, Rani, Reena, Rathbun, Keaney R, Geiger, Hartmut, Williams, David A, Bagby, Grover C, Pang, Qishen

“…The molecular pathogenesis of the myeloid leukemias that frequently occur in patients with Fanconi anemia (FA) is not well defined. Hematopoietic stem cells…”
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Hypoxia-induced Nucleophosmin Protects Cell Death through Inhibition of p53 by Li, June, Zhang, Xiaoling, Sejas, Daniel P, Bagby, Grover C, Pang, Qishen

“…Nucleophosmin (NPM) is a multifunctional protein that is overexpressed in actively proliferating cells and cancer cells. Here we report that this…”
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Discovering early molecular determinants of leukemogenesis by Bagby, Grover C

“…Truncating mutations of the G-CSF receptor are found during disease course in nearly half of all patients with severe congenital neutropenia. In this issue of…”
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Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia by Pulliam-Leath, Anna C., Ciccone, Samantha L., Nalepa, Grzegorz, Li, Xiaxin, Si, Yue, Miravalle, Leticia, Smith, Danielle, Yuan, Jin, Li, Jingling, Anur, Praveen, Orazi, Attilio, Vance, Gail H., Yang, Feng-Chun, Hanenberg, Helmut, Bagby, Grover C., Clapp, D. Wade

“…Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia…”
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Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer by PEJOVIC, Tanja, YATES, Jane E, AMEZIANE, Najim, ZWAAN, C. Michael, ERRAMI, Abdellatif, THUILLIER, Philippe, CAPPUCCINI, Fabio, OLSON, Susan B, CAIN, Joanna M, BAGBY, Grover C, LIU, Hong Y, HAYS, Laura E, AKKARI, Yassmine, TORIMARU, Yumi, KEEBLE, Winifred, RATHBUN, R. Keaney, RODGERS, William H, BALE, Alien E

“…Fanconi anemia is an inherited cancer predisposition disease characterized by cytogenetic and cellular hypersensitivity to cross-linking agents. Seeking…”
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TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice by Zhou, Yun, Du, Wei, Koretsky, Tara, Bagby, Grover C., Pang, Qishen

“…Nucleophosmin (NPM) is frequently overexpressed in leukemias and other tumors. NPM has been reported to suppress oncogene-induced senescence and apoptosis and…”
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p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes by Anur, Praveen, Yates, Jane, Garbati, Michael R., Vanderwerf, Scott, Keeble, Winifred, Rathbun, Keaney, Hays, Laura E., Tyner, Jeffrey W., Svahn, Johanna, Cappelli, Enrico, Dufour, Carlo, Bagby, Grover C.

“…Fanconi anemia, complementation group C (FANCC)–deficient hematopoietic stem and progenitor cells are hypersensitive to a variety of inhibitory cytokines, one…”
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The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers by Pitman, Janet L, McNeilly, Alan S, McNeilly, Judy R, Hays, Laura E, Bagby, Jr, Grover C, Sawyer, Heywood R, McNatty, Kenneth P

“…This review examines the importance of the epithelial origin of granulosa cells and their possible contribution to the development of ovarian cancers in three…”
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