Search Results - "BAGAVANT, Harini"

Pathogenesis of kidney disease in systemic lupus erythematosus by Bagavant, Harini, Fu, Shu Man

“…PURPOSE OF REVIEWA combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review,…”
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Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sjögren's Sicca Syndrome by Papinska, Joanna A, Durślewicz, Justyna, Bagavant, Harini, Deshmukh, Umesh S

“…Elevated oxidative stress can play a pivotal role in autoimmune diseases by exacerbating inflammatory responses and tissue damage. In Sjögren's disease (SjD),…”
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Dysregulated Ca2+ signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren’s disease by Huang, Kai-Ting, Wagner, Larry E, Takano, Takahiro, Lin, Xiao-Xuan, Bagavant, Harini, Deshmukh, Umesh, Yule, David I

“…The molecular mechanisms leading to saliva secretion are largely established, but factors that underlie secretory hypofunction, specifically related to the…”
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Pulmonary Involvement in a Mouse Model of Sjögren's Syndrome Induced by STING Activation by Papinska, Joanna, Bagavant, Harini, Gmyrek, Grzegorz B, Deshmukh, Umesh S

“…Sjögren's Syndrome (SS), a chronic autoimmune disorder affecting multiple organ systems, is characterized by an elevated type I interferon (IFN) response…”
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Mesangial pathology in glomerular disease: targets for therapeutic intervention by Scindia, Yogesh M., Deshmukh, Umesh S., Bagavant, Harini

“…The glomerulus is the filtration unit of the kidney. Disruption of glomerular function may be caused by primary glomerular pathology or secondary to systemic…”
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STING Agonist-Induced Skin Inflammation Is Exacerbated with Prior Systemic Innate Immune Activation by Pyclik, Marcelina, Durslewicz, Justyna, Papinska, Joanna A, Deshmukh, Umesh S, Bagavant, Harini

“…Activation of the Stimulator of Interferon Genes (STING) protein has paradoxical outcomes in skin disease. STING activation exacerbates psoriatic skin disease…”
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IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection by Ainsua-Enrich, Erola, Hatipoglu, Ibrahim, Kadel, Sapana, Turner, Sean, Paul, Jinny, Singh, Simar, Bagavant, Harini, Kovats, Susan

“…Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual vaccination to select strains. Development of vaccines that elicit…”
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Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging mice by Bagavant, Harini, Durslewicz, Justyna, Pyclik, Marcelina, Makuch, Magdalena, Papinska, Joanna A., Deshmukh, Umesh S.

“…Sjögren’s disease (SjD), characterized by circulating autoantibodies and exocrine gland inflammation, is typically diagnosed in women over 50 years of age…”
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Immune Response to  Enterococcus gallinarum in Lupus Patients Is Associated With a Subset of Lupus-Associated Autoantibodies by Bagavant, Harini, Araszkiewicz, Antonina M, Ingram, Jessica K, Cizio, Katarzyna, Merrill, Joan T, Arriens, Cristina, Guthridge, Joel M, James, Judith A, Deshmukh, Umesh S

“…Interactions between gut microbes and the immune system influence autoimmune disorders like systemic lupus erythematosus (SLE). Recently, , a gram-positive…”
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Immune Response Targeting Sjögren's Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice by Trzeciak, Marta, Bagavant, Harini, Papinska, Joanna, Deshmukh, Umesh S

“…Autoantibodies reactive against Ro52 are present in 70% of Sjögren's syndrome patients and are associated with higher disease severity. However, their role in…”
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Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis by Garman, Lori, Pelikan, Richard C, Rasmussen, Astrid, Lareau, Caleb A, Savoy, Kathryn A, Deshmukh, Umesh S, Bagavant, Harini, Levin, Albert M, Daouk, Salim, Drake, Wonder P, Montgomery, Courtney G

“…Sarcoidosis is a systemic inflammatory disease characterized by infiltration of immune cells into granulomas. Previous gene expression studies using…”
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Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney by Song, Kai, Fu, Jianxin, Song, Jianhua, Herzog, Brett H., Bergstrom, Kirk, Kondo, Yuji, McDaniel, J. Michael, McGee, Samuel, Silasi-Mansat, Robert, Lupu, Florea, Chen, Hong, Bagavant, Harini, Xia, Lijun

“…The kidney's filtration activity is essential for removing toxins and waste products from the body. The vascular endothelial cells of the glomerulus are…”
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BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation by Wu, Ying-Yu, Kumar, Ramesh, Iida, Ryuji, Bagavant, Harini, Alarcón-Riquelme, Marta E

“…The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease…”
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Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice by Szczerba, Barbara M, Kaplonek, Paulina, Wolska, Nina, Podsiadlowska, Anna, Rybakowska, Paulina D, Dey, Paromita, Rasmussen, Astrid, Grundahl, Kiely, Hefner, Kimberly S, Stone, Donald U, Young, Stephen, Lewis, David M, Radfar, Lida, Scofield, R Hal, Sivils, Kathy L, Bagavant, Harini, Deshmukh, Umesh S

“…Autoantibodies reactive with Ro52 are often found in sera of patients with Sjögren's syndrome (SS). This study was undertaken to investigate the role of…”
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Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels by Wu, Ying-Yu, Georg, Ina, Díaz-Barreiro, Alejandro, Varela, Nieves, Lauwerys, Bernard, Kumar, Ramesh, Bagavant, Harini, Castillo-Martín, Mireia, El Salem, Fadi, Marañón, Concepción, Alarcón-Riquelme, Marta E

“…Polymorphisms in the B lymphoid tyrosine kinase (BLK) gene have been associated with autoimmune diseases, including systemic lupus erythematosus, with risk…”
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Systemic immune response to vimentin and granuloma formation in a model of pulmonary sarcoidosis by Bagavant, Harini, Cizio, Katarzyna, Araszkiewicz, Antonina M., Papinska, Joanna A., Garman, Lori, Li, Chuang, Pezant, Nathan, Drake, Wonder P., Montgomery, Courtney G., Deshmukh, Umesh S.

“…A characteristic feature of sarcoidosis is a dysregulated immune response to persistent stimuli, often leading to the formation of non-necrotizing granulomas…”
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1403 The EIF4 translational inhibitor pateamine a improves immunological and neurological functions in BXSB.yaa lupus mice by Gómez-Hernández, Gonzalo, Varela, Nieves, Bagavant, Harini, Barturen, Guillermo, Morell, María, Alarcón-Riquelme, Marta E

“…BackgroundSystemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance and activation of the immune response. Clinical…”
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Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function by Deshmukh, Umesh S., Nandula, Seshagiri Rao, Thimmalapura, Pushpa-Rekha, Scindia, Yogesh M, Bagavant, Harini

“…Background:  Recent studies have demonstrated the expression of Toll‐like receptor 3 (TLR3) in salivary glands and epithelial cell lines derived from Sjögren’s…”
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Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling by Nandula, Seshagiri-Rao, Dey, Paromita, Corbin, Kathryn L., Nunemaker, Craig S., Bagavant, Harini, Deshmukh, Umesh S.

“…Background:  Activation of innate immunity through polyinosinic:polycytidylic acid [poly(I:C)] causes acute salivary gland hypofunction. As a major consequence…”
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Novel Therapeutic Approaches to Lupus Glomerulonephritis: Translating Animal Models to Clinical Practice by Bagavant, Harini, MBBS, PhD, Kalantarinia, Kambiz, MD, MS, Scindia, Yogesh, PhD, Deshmukh, Umesh, PhD

“…Systemic lupus erythematosus is a chronic autoimmune disease frequently affecting the kidney. Renal involvement is characterized by glomerular immune complex…”
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