Search Results - "BAFICA, André"

Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis by Dirkx, Laura, Hendrickx, Sarah, Merlot, Margot, Bulté, Dimitri, Starick, Marick, Elst, Jessy, Bafica, André, Ebo, Didier G., Maes, Louis, Van Weyenbergh, Johan, Caljon, Guy

“…Given the discontinuation of various first-line drugs for visceral leishmaniasis (VL), large-scale in vivo drug screening, establishment of a relapse model in…”
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Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis saliva by Sá-Nunes, Anderson, Bafica, André, Lucas, David A, Conrads, Thomas P, Veenstra, Timothy D, Andersen, John F, Mather, Thomas N, Ribeiro, José M C, Francischetti, Ivo M B

“…Tick saliva is thought to contain a number of molecules that prevent host immune and inflammatory responses. In this study, the effects of Ixodes scapularis…”
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Trypanosoma cruzi Infection Is Enhanced by Vector Saliva through Immunosuppressant Mechanisms Mediated by Lysophosphatidylcholine by Mesquita, Rafael D, Carneiro, Alan Brito, Bafica, André, Gazos-Lopes, Felipe, Takiya, Christina M, Souto-Padron, Thaís, Vieira, Danielle P, Ferreira-Pereira, Antônio, Almeida, Igor C, Figueiredo, Rodrigo T, Porto, Bárbara N, Bozza, Marcelo T, Graça-Souza, Aurélio V, Lopes, Angela H.C.S, Atella, Geórgia C, Silva-Neto, Mário A.C

“…Trypanosoma cruzi, the etiological agent of Chagas disease, is transmitted by bug feces deposited on human skin during a blood meal. However, parasite…”
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Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges by Silva, Hernandez Moura, Báfica, André, Rodrigues-Luiz, Gabriela Flavia, Chi, Jingyi, Santos, Patricia d'Emery Alves, Reis, Bernardo S, Hoytema van Konijnenburg, David P, Crane, Audrey, Arifa, Raquel Duque Nascimento, Martin, Patricia, Mendes, Daniel Augusto G B, Mansur, Daniel Santos, Torres, Victor J, Cadwell, Ken, Cohen, Paul, Mucida, Daniel, Lafaille, Juan J

“…Tissue-resident macrophages are the most abundant immune cell population in healthy adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic…”
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An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans by Delgobo, Murilo, Mendes, Daniel Agb, Kozlova, Edgar, Rocha, Edroaldo Lummertz, Rodrigues-Luiz, Gabriela F, Mascarin, Lucas, Dias, Greicy, Patrício, Daniel O, Dierckx, Tim, Bicca, Maíra A, Bretton, Gaëlle, Tenório de Menezes, Yonne Karoline, Starick, Márick R, Rovaris, Darcita, Del Moral, Joanita, Mansur, Daniel S, Van Weyenbergh, Johan, Báfica, André

“…Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether ( ) directly regulates myeloid commitment. We demonstrated…”
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Chitosan/genipin modified electrode for voltammetric determination of interleukin-6 as a biomarker of sepsis by de Matos Morawski, Franciele, Dias, Greicy Brisa Malaquias, Sousa, Kelline Alaide Pereira, Formiga, Rodrigo, Spiller, Fernando, Parize, Alexandre Luis, Báfica, André, Jost, Cristiane Luisa

“…Ultrasensitive electroanalytical monitoring of interleukin-6 levels in serum samples has emerged as a valuable tool for the early diagnosis of inflammatory…”
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Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection by Novais, Fernanda O, Santiago, Romulo C, Bafica, Andre, Khouri, Ricardo, Afonso, Lilian, Borges, Valeria M, Brodskyn, Claudia, Barral-Netto, Manoel, Barral, Aldina, de Oliveira, Camila I

“…Neutrophils play an active role in the control of infections caused by intracellular pathogens such as Leishmania. In the present study, we investigated the…”
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DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response by Patricio, Daniel de Oliveira, Dias, Greicy Brisa Malaquias, Granella, Lucilene Wildner, Trigg, Ben, Teague, Helena Claire, Bittencourt, Dina, Báfica, André, Zanotto-Filho, Alfeu, Ferguson, Brian, Mansur, Daniel Santos

“…Zika virus (ZIKV) is a single-strand RNA mosquito-borne flavivirus with significant public health impact. ZIKV infection induces double-strand DNA breaks…”
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COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice by Gonçalves, Rosângela Mayer, Delgobo, Marina, Agnes, Jonathan Paulo, das Neves, Raquel Nascimento, Falchetti, Marcelo, Casagrande, Tuany, Garcia, Ana Paula Vargas, Vieira, Thaynan Cunha, Somensi, Nauana, Bruxel, Maciel Alencar, Mendes, Daniel Augusto Gasparin Bueno, Rafacho, Alex, Báfica, André, Gelain, Daniel Pens, Moreira, José Cláudio Fonseca, Cassali, Geovanni Dantas, Bishop, Alexander James Roy, Zanotto-Filho, Alfeu

“…Obesity is a major risk factor for breast cancer, especially in post-menopausal women. In the breast tissue of obese women, cyclooxygenase-2 (COX-2)-dependent…”
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Asymptomatic cattle naturally infected with Mycobacterium bovis present exacerbated tissue pathology and bacterial dissemination by Menin, Álvaro, Fleith, Renata, Reck, Carolina, Marlow, Mariel, Fernandes, Paula, Pilati, Célso, Báfica, André

“…Rational discovery of novel immunodiagnostic and vaccine candidate antigens to control bovine tuberculosis (bTB) requires knowledge of disease…”
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ISG15/USP18/STAT2 is a molecular hub regulating IFN I-mediated control of Dengue and Zika virus replication by Espada, Constanza Eleonora, da Rocha, Edroaldo Lummertz, Ricciardi-Jorge, Taissa, Dos Santos, Adara Aurea, Soares, Zamira Guerra, Malaquias, Greicy, Patrício, Daniel Oliveira, Gonzalez Kozlova, Edgar, Dos Santos, Paula Fernandes, Bordignon, Juliano, Sanford, Thomas J, Fajardo, Teodoro, Sweeney, Trevor R, Báfica, André, Mansur, Daniel Santos

“…The establishment of a virus infection is the result of the pathogen's ability to replicate in a hostile environment generated by the host's immune system…”
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Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population by Antonelli, Lis R V, Gigliotti Rothfuchs, Antonio, Gonçalves, Ricardo, Roffê, Ester, Cheever, Allen W, Bafica, Andre, Salazar, Andres M, Feng, Carl G, Sher, Alan

“…Type I IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type I…”
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IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis by Khouri, Ricardo, Bafica, André, Silva, Maria da Purificação Pereira, Noronha, Almerio, Kolb, Jean-Pierre, Wietzerbin, Juana, Barral, Aldina, Barral-Netto, Manoel, Van Weyenbergh, Johan

“…Type I IFNs (IFN-alpha/beta) have only recently gained considerable attention as immunomodulators in nonviral infectious diseases. IFN-beta has been shown to…”
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ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis by Dos Santos, Paula Fernandes, Van Weyenbergh, Johan, Delgobo, Murilo, Oliveira Patricio, Daniel de, Ferguson, Brian J, Guabiraba, Rodrigo, Dierckx, Tim, Menezes, Soraya Maria, Báfica, André, Mansur, Daniel Santos

“…IFN-stimulated gene 15 (ISG15) deficiency in humans leads to severe IFNopathies and mycobacterial disease, the latter being previously attributed to its…”
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Recombinant Bacillus Calmette-Guérin Expressing SARS-CoV-2 Chimeric Protein Protects K18-hACE2 Mice against Viral Challenge by Mambelli, Fábio, Marinho, Fábio V, Andrade, Juvana M, de Araujo, Ana C V S C, Abuna, Rodrigo P F, Fabri, Victor M R, Santos, Bruno P O, da Silva, João S, de Magalhães, Mariana T Q, Homan, E Jane, Leite, Luciana C C, Dias, Greicy B M, Heck, Nicoli, Mendes, Daniel A G B, Mansur, Daniel S, Báfica, André, Oliveira, Sergio C

“…COVID-19 has accounted for more than 6 million deaths worldwide. Bacillus Calmette-Guérin (BCG), the existing tuberculosis vaccine, is known to induce…”
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Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection by Bafica, Andre, Santiago, Helton Costa, Goldszmid, Romina, Ropert, Catherine, Gazzinelli, Ricardo T, Sher, Alan

“…Activation of innate immune cells by Trypanosoma cruzi-derived molecules such as GPI anchors and DNA induces proinflammatory cytokine production and host…”
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The Endogenous Retinoic Acid Receptor Pathway Is Exploited by Mycobacterium tuberculosis during Infection, Both In Vitro and In Vivo by Tenório de Menezes, Yonne Karoline, Eto, Carolina, de Oliveira, Joseana, Larson, Erica C, Mendes, Daniel A G B, Dias, Greicy Brisa Malaquias, Delgobo, Murilo, Gubernat, Abigail K, Gleim, Janelle L, Munari, Eduarda Laís, Starick, Marick, Ferreira, Fabienne, Mansur, Daniel Santos, Costa, Diego L, Scanga, Charles A, Báfica, André

“…Retinoic acid (RA) is a fundamental vitamin A metabolite involved in regulating immune responses through the nuclear RA receptor (RAR) and retinoid X receptor…”
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B 1 and B 2 kinin receptor blockade improves psoriasis-like disease by Soley, Bruna da Silva, Silva, Leonardo Martins, Mendes, Daniel Augusto Gasparin Bueno, Báfica, André, Pesquero, João Bosco, Bader, Michael, Witherden, Deborah A, Havran, Wendy L, Calixto, João B, Otuki, Michel Fleith, Cabrini, Daniela Almeida

“…The entire kallikrein-kinin system is present in the skin, and it is thought to exert a relevant role in cutaneous diseases, including psoriasis. The present…”
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Innate immune sensing of nucleic acids from mycobacteria by Yamashiro, Lívia Harumi, Oliveira, Sérgio Costa, Báfica, André

“…Endosomal and cytosolic receptors engage recognition of mycobacterial-derived nucleic acids (MyNAs). In contrast, virulent mycobacteria may utilize nucleic…”
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Isoniazid‐induced control of Mycobacterium tuberculosis by primary human cells requires interleukin‐1 receptor and tumor necrosis factor by Yamashiro, Lívia H., Eto, Carolina, Soncini, Marina, Horewicz, Verônica, Garcia, Magno, Schlindwein, Aline D., Grisard, Edmundo C., Rovaris, Darcita B., Báfica, André

“…Proinflammatory cytokines are critical mediators that control Mycobacterium tuberculosis (Mtb) growth during active tuberculosis (ATB). To further inhibit…”
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