The nature of introns 4-6 suggests reduced lineage specificity in HLA-B alleles

The nature of introns 4-6 suggests reduced lineage specificity in HLA-B alleles

For most HLA-B alleles, coding sequences of the 3' part of the genes still need to be determined, and sequences of the 3' noncoding regions have yet to be studied systematically. In this study, we have determined the sequences of introns 4-6 in all HLA-B allelic groups, and computed nucleo...

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Bibliographic Details
Published in:Genes and immunity Vol. 4; no. 6; pp. 391 - 401
Main Authors: ELSNER, H-A, BAENGEROTH, K, BLASCZYK, R
Format: Journal Article
Language:English
Published: Basingstoke Nature Publishing Group 01-09-2003
Subjects:
Alleles
Base Sequence
Biological and medical sciences
Cell Lineage
Classical genetics, quantitative genetics, hybrids
DNA - genetics
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genes
Genetic Variation
Genetics of eukaryotes. Biological and molecular evolution
Haplotypes
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
HLA-B Antigens - genetics
HLA-B Antigens - immunology
Human
Humans
Introns
Introns - genetics
Major histocompatibility complex
Molecular Sequence Data
Phylogenetics
Phylogeny
Physiological aspects
Polymorphism
Polymorphism, Genetic
Recombination
Recombination, Genetic
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Serology
Germany
Human
Allele
Recombination
Specificity
Intron
Nucleotide sequence
Genetic diversity
Class I histocompatibility antigen
HLA-B-Locus
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Summary:For most HLA-B alleles, coding sequences of the 3' part of the genes still need to be determined, and sequences of the 3' noncoding regions have yet to be studied systematically. In this study, we have determined the sequences of introns 4-6 in all HLA-B allelic groups, and computed nucleotide substitution rates and phylogenetic relationships. These sequences demonstrated an inconsistent pattern of intralineage specificity, intralineage diversity, and interlineage diversity that is best characterized by a patchwork pattern. Apart from phylogenetic studies about HLA diversity and diversification, the sequence data obtained in our study may prove valuable for haplotype-specific sequencing of the 3' part of HLA-B and for the explanation of recombination events in newly described HLA-B alleles.
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ISSN:1466-4879
1476-5470
DOI:10.1038/sj.gene.6363981