Search Results - "BAE, Seog"

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury by Davies, Alexander J., Kim, Hyoung Woo, Gonzalez-Cano, Rafael, Choi, Jahyang, Back, Seung Keun, Roh, Seung Eon, Johnson, Errin, Gabriac, Melanie, Kim, Mi-Sun, Lee, Jaehee, Lee, Jeong Eun, Kim, Yun Sook, Bae, Yong Chul, Kim, Sang Jeong, Lee, Kyung-Mi, Na, Heung Sik, Riva, Priscilla, Latremoliere, Alban, Rinaldi, Simon, Ugolini, Sophie, Costigan, Michael, Oh, Seog Bae

“…Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged axons preserved…”
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Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade by Xu, Zhen-Zhong, Kim, Yong Ho, Bang, Sangsu, Zhang, Yi, Berta, Temugin, Wang, Fan, Oh, Seog Bae, Ji, Ru-Rong

“…Toll-like receptor 5 (TLR5) expression is found to be enriched in mouse dorsal root ganglion (DRG) A-fiber neurons known to mediate mechanical allodynia, a…”
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Cytotoxic Immunity in Peripheral Nerve Injury and Pain by Davies, Alexander J, Rinaldi, Simon, Costigan, Michael, Oh, Seog Bae

“…Cytotoxicity and consequent cell death pathways are a critical component of the immune response to infection, disease or injury. While numerous examples of…”
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Clonidine, an alpha‐2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin‐induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension by Yeo, Ji‐Hee, Yoon, Seo‐Yeon, Kim, Sol‐Ji, Oh, Seog‐Bae, Lee, Jang‐Hern, Beitz, Alvin J., Roh, Dae‐Hyun

“…Cancer chemotherapy with platinum‐based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We…”
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TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord by Kim, Yong Ho, Back, Seung Keun, Davies, Alexander J., Jeong, Heejin, Jo, Hyun Jung, Chung, Geehoon, Na, Heung Sik, Bae, Yong Chul, Kim, Sang Jeong, Kim, Joong Soo, Jung, Sung Jun, Oh, Seog Bae

“…Neuropathic pain and allodynia may arise from sensitization of central circuits. We report a mechanism of disinhibition-based central sensitization resulting…”
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Alpha 2 adrenoceptor agonist guanabenz directly inhibits hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels in mesencephalic trigeminal nucleus neurons by Won, Jonghwa, Lee, Pa Reum, Oh, Seog Bae

“…Alpha 2 (α2-) adrenoceptor agonists, such as clonidine or dexmedetomidine, have been found to inhibit hyperpolarization-activated, cyclic nucleotide-modulated…”
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Molecular expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts by Won, Jonghwa, Kim, Ji Hyun, Oh, Seog Bae

“…•CNNM4 is mainly expressed in TRPM7-positive odontoblasts.•TRPM7 is ubiquitously expressed along the odontoblastic layer.•CNNM4 is preferentially expressed in…”
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A Critical Role of Toll-like Receptor 2 in Nerve Injury-induced Spinal Cord Glial Cell Activation and Pain Hypersensitivity by Kim, Donghoon, Kim, Myung Ah, Cho, Ik-Hyun, Kim, Mi Sun, Lee, Soojin, Jo, Eun-Kyeong, Choi, Se-Young, Park, Kyungpyo, Kim, Joong Soo, Akira, Shizuo, Na, Heung Sik, Oh, Seog Bae, Lee, Sung Joong

“…The activation of spinal cord glial cells has been implicated in the development of neuropathic pain upon peripheral nerve injury. The molecular mechanisms…”
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Reduced acute nociception and chronic pain in Shank2−/− mice by Ko, Hyoung-Gon, Oh, Seog-Bae, Zhuo, Min, Kaang, Bong-Kiun

“…Autism spectrum disorder is a debilitating mental illness and social issue. Autism spectrum disorder patients suffer from social isolation, cognitive deficits,…”
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Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents by BINSHTOK, Alexander M, GERNER, Peter, MITANI, Aya A, GING KUO WANG, BEAN, Bruce P, WOOLF, Clifford J, BAE, Seog, PUOPOLO, Michelino, SUZUKI, Suzuko, ROBERSON, David P, HERBERT, Teri, WANG, Chi-Fei, KIM, Donghoon, CHUNG, Gehoon

“…Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with…”
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Peripheral GABAA receptor-mediated signaling facilitates persistent inflammatory hypersensitivity by Lee, Pa Reum, Yoon, Seo-Yeon, Kim, Hyoung Woo, Yeo, Ji-Hee, Kim, Yong Ho, Oh, Seog Bae

“…Unlike in the central nervous system (CNS), in the adult peripheral nervous system (PNS), activation of GABAA receptors (GABAAR) is excitatory because of the…”
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Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats by Davies, Alexander J., Kim, Doyun, Park, Jeongrak, Lee, Jeong-Yun, Vang, Hue, Pickering, Anthony E., Oh, Seog Bae

“…The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a…”
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High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury by Jeong, Heejin, Na, Young-Ji, Lee, Kihwan, Kim, Yong Ho, Lee, Yunsin, Kang, Minho, Jiang, Bao-Chun, Yeom, Young Il, Wu, Long-Jun, Gao, Yong-Jing, Kim, Junhyong, Oh, Seog Bae

“…Microglial cells, the resident immune cells of the spinal cord, become activated in response to peripheral nerve injury. Microglia activation contributes to…”
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TRANSCRIPTIONAL PROFILING OF DENTAL SENSORY AND PROPRIOCEPTIVE TRIGEMINAL NEURONS USING SINGLE-CELL RNA-SEQUENCING by Oh, Seog Bae, Lee, Pa Reum, Kim, Jihoon, Kim, Junhyong

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Recent advances in basic research on the trigeminal ganglion by Goto, Tetsuya, Oh, Seog Bae, Takeda, Mamoru, Shinoda, Masamichi, Sato, Tadasu, Gunjikake, Kaori K, Iwata, Koichi

“…Peripheral tissue inflammation can alter the properties of somatic sensory pathways, causing behavioral hypersensitivity and resulting in increased responses…”
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Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314 by Puopolo, Michelino, Binshtok, Alexander M, Yao, Gui-Lan, Oh, Seog Bae, Woolf, Clifford J, Bean, Bruce P

“…QX-314 (N-ethyl-lidocaine) is a cationic lidocaine derivative that blocks voltage-dependent sodium channels when applied internally to axons or neuronal cell…”
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The analgesic effect of refeeding on acute and chronic inflammatory pain by Lee, Jeong-Yun, Lee, Grace J., Lee, Pa Reum, Won, Chan Hee, Kim, Doyun, Kang, Youngnam, Oh, Seog Bae

“…Pain is susceptible to various cognitive factors. Suppression of pain by hunger is well known, but the effect of food intake after fasting (i.e. refeeding) on…”
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Spinal sigma-1 receptor activation increases the production of d-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain by Moon, Ji-Young, Choi, Sheu-Ran, Roh, Dae-Hyun, Yoon, Seo-Yeon, Kwon, Soon-Gu, Choi, Hoon-Seong, Kang, Suk-Yun, Han, Ho-Jae, Kim, Hyun-Woo, Beitz, Alvin J., Oh, Seog-Bae, Lee, Jang-Hern

“…[Display omitted] DAAO, d-amino acid oxidase; i.t., intrathecal; LSOS, l-serine O-sulfate potassium salt; NMDA R, N-methyl-d-aspartate receptor; Sig-1R,…”
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Microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat model of inflammatory pain by Choi, Hoon-Seong, Roh, Dae-Hyun, Yoon, Seo-Yeon, Moon, Ji-Young, Choi, Sheu-Ran, Kwon, Soon-Gu, Kang, Suk-Yun, Han, Ho-Jae, Kim, Hyun-Woo, Beitz, Alvin J., Oh, Seog-Bae, Lee, Jang-Hern

“…Damage on one side of the body can also result in pain on the contralateral unaffected side, called mirror-image pain (MIP). Currently, the mechanisms…”
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The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury by Peng, Jiyun, Yi, Min-Hee, Jeong, Heejin, McEwan, Przemyslaw Peter, Zheng, Jiaying, Wu, Gongxiong, Ganatra, Shashank, Ren, Yi, Richardson, Jason R, Oh, Seog Bae, Wu, Long-Jun

“…Activation of spinal cord microglia contributes to the development of peripheral nerve injury-induced neuropathic pain. However, the molecular mechanisms…”
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