Search Results - "BADGWELL, Donna"

Development of a Multimarker Assay for Early Detection of Ovarian Cancer by YURKOVETSKY, Zoya, SKATES, Steven, MENON, Usha, LU, Karen, BADGWELL, Donna, BAST, Robert C, LOKSHIN, Anna E, LOMAKIN, Aleksey, NOLEN, Brian, PULSIPHER, Trenton, MODUGNO, Francesmary, MARKS, Jeffrey, GODWIN, Andrew, GORELIK, Elieser, JACOBS, Ian

“…Early detection of ovarian cancer has great promise to improve clinical outcome. Ninety-six serum biomarkers were analyzed in sera from healthy women and from…”
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Early detection of ovarian cancer by Badgwell, Donna, Bast, Jr, Robert C

“…Despite advances in therapy, ovarian cancer remains the most deadly of the gynecological cancers. Less than 30% of women with advanced stage disease survive…”
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Validation of a Biomarker Panel and Longitudinal Biomarker Performance for Early Detection of Ovarian Cancer by Simmons, Archana R, Clarke, Charlotte H, Badgwell, Donna B, Lu, Zhen, Sokoll, Lori J, Lu, Karen H, Zhang, Zhen, Bast, Jr, Robert C, Skates, Steven J

“…Longitudinal multimarker combinations have the potential to improve sensitivity while maintaining the high specificity required for the early detection of…”
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Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer by Clarke, Charlotte H, Yip, Christine, Badgwell, Donna, Fung, Eric T, Coombes, Kevin R, Zhang, Zhen, Lu, Karen H, Bast, Robert C

“…Abstract Objective The low prevalence of ovarian cancer demands both high sensitivity (> 75%) and specificity (99.6%) to achieve a positive predictive value of…”
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IL-6 signaling via the STAT3/SOCS3 pathway: Functional Analysis of the Conserved STAT3 N-domain by Zhang, Ling, Badgwell, Donna B, Bevers, Jack J. III, Schlessinger, Karni, Murray, Peter J, Levy, David E, Watowich, Stephanie S

“…The conserved N-domain of the STAT proteins has been implicated in several activities crucial to cytokine signaling including receptor recruitment and STAT…”
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Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors by Badgwell, Donna B., Walker, Christopher M., Baker, Whitney T., Strickland, Faith M.

“…Mutations in the p53 tumor‐suppressor gene contribute to the development of skin cancer, and the spectrum of mutations in this gene correlates with specific…”
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Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus by Moore, Richard G, Brown, Amy K, Miller, M. Craig, Badgwell, Donna, Lu, Zhen, Allard, W. Jeffrey, Granai, C.O, Bast, Robert C, Lu, Karen

“…Abstract Objective Tumor markers with increased sensitivity and specificity for endometrial cancer are needed to help monitor response to therapy and to detect…”
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The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways by Badgwell, D B, Lu, Z, Le, K, Gao, F, Yang, M, Suh, G K, Bao, J-J, Das, P, Andreeff, M, Chen, W, Yu, Y, Ahmed, A A, S-L Liao, W, Bast, R C

“…Ovarian cancers migrate and metastasize over the surface of the peritoneal cavity. Consequently, dysregulation of mechanisms that limit cell migration may be…”
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Urinary mesothelin provides greater sensitivity for early stage ovarian cancer than serum mesothelin, urinary hCG free beta subunit and urinary hCG beta core fragment by Badgwell, Donna, Lu, Zhen, Cole, Laurence, Fritsche, Herbert, Atkinson, Edward N, Somers, Elizabeth, Allard, Jeffrey, Moore, Richard G, Lu, Karen H, Bast, Robert C

“…Abstract Objectives. Early detection of ovarian cancer should improve overall survival. Multiple serum markers have been evaluated as possible tests to detect…”
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Urinary levels of Bcl-2 are elevated in ovarian cancer patients by Anderson, Nicole S, Bermudez, Yira, Badgwell, Donna, Chen, Ren, Nicosia, Santo V, Bast, Robert C, Kruk, Patricia A

“…Abstract Objective(s) The poor prognosis associated with ovarian cancer is due to the lack of overt early symptoms and the absence of reliable diagnostic…”
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Prevention and early detection of ovarian cancer: mission impossible? by Bast, Jr, Robert C, Brewer, Molly, Zou, Changping, Hernandez, Mary A, Daley, Mary, Ozols, Robert, Lu, Karen, Lu, Zhen, Badgwell, Donna, Mills, Gordon B, Skates, Steven, Zhang, Zhen, Chan, Dan, Lokshin, Anna, Yu, Yinhua

“…Epithelial ovarian cancer is neither a common nor a rare disease. In the United States, the prevalence of ovarian cancer in postmenopausal women (1 in 2,500)…”
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Biochemistry and biology of ARHI (DIRAS3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers by Yu, Yinhua, Luo, Robert, Lu, Zhen, Wei Feng, Wei, Badgwell, Donna, Issa, Jean-Pierre, Rosen, Daniel G, Liu, Jinsong, Bast, Jr, Robert C

“…ARHI is a maternally imprinted tumor suppressor gene that is downregulated in 60% of ovarian and breast cancers. Loss of ARHI expression is associated with…”
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The role of the conserved N -terminal domain of STAT3 in STAT3 dephosphorylation and nuclear export by Badgwell, Donna Beard

“…Rapid redistribution of STAT subcellular localization is an essential feature of cytokine signaling. To elucidate the molecular basis of STAT3 function, which…”
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