Search Results - "BADELL, I. R"

Islet Xenotransplantation Using Gal‐Deficient Neonatal Donors Improves Engraftment and Function by Thompson, P., Badell, I. R., Lowe, M., Cano, J., Song, M., Leopardi, F., Avila, J., Ruhil, R., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Iwakoshi, N., Larsen, C. P., Kirk, A. D.

“…Significant deficiencies in understanding of xenospecific immunity have impeded the success of preclinical trials in xenoislet transplantation. Although…”
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CD40‐Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates by Thompson, P., Cardona, K., Russell, M., Badell, I. R., Shaffer, V., Korbutt, G., Rayat, G. R., Cano, J., Song, M., Jiang, W., Strobert, E., Rajotte, R., Pearson, T., Kirk, A. D., Larsen, C. P.

“…The widespread clinical implementation of alloislet transplantation as therapy for type 1 diabetes has been hindered by the lack of suitable islet donors…”
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Alternative Immunomodulatory Strategies for Xenotransplantation: CD40/154 Pathway‐Sparing Regimens Promote Xenograft Survival by Thompson, P., Badell, I. R., Lowe, M., Turner, A., Cano, J., Avila, J., Azimzadeh, A., Cheng, X., Pierson III, R. N., Johnson, B., Robertson, J., Song, M., Leopardi, F., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Larsen, C. P., Kirk, A. D.

“…Immunosuppressive therapies that block the CD40/CD154 costimulatory pathway have proven to be uniquely effective in preclinical xenotransplant models. Given…”
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Experience with a Novel Efalizumab‐Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation by Turgeon, N. A., Avila, J. G., Cano, J. A., Hutchinson, J. J., Badell, I. R., Page, A. J., Adams, A. B., Sears, M. H., Bowen, P. H., Kirk, A. D., Pearson, T. C., Larsen, C. P.

“…Islet transplantation is an experimental therapy for selected patients with type 1 diabetes (T1DM). It remains limited by immunosuppressive drug toxicity,…”
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Nondepleting Anti‐CD40‐Based Therapy Prolongs Allograft Survival in Nonhuman Primates by Badell, I. R., Thompson, P. W., Turner, A. P., Russell, M. C., Avila, J. G., Cano, J. A., Robertson, J. M., Leopardi, F. V., Strobert, E. A., Iwakoshi, N. N., Reimann, K. A., Ford, M. L., Kirk, A. D., Larsen, C. P.

“…Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has…”
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Belatacept and Sirolimus Prolong Nonhuman Primate Islet Allograft Survival: Adverse Consequences of Concomitant Alefacept Therapy by Lowe, M. C., Badell, I. R., Turner, A. P., Thompson, P. W., Leopardi, F. V., Strobert, E. A., Larsen, C. P., Kirk, A. D.

“…Calcineurin inhibitors (CNI) and steroids are known to promote insulin resistance, and their avoidance after islet transplantation is preferred from a…”
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A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival by Lowe, M., Badell, I. R., Thompson, P., Martin, B., Leopardi, F., Strobert, E., Price, A. A., Abdulkerim, H. S., Wang, R., Iwakoshi, N. N., Adams, A. B., Kirk, A. D., Larsen, C. P., Reimann, K. A.

“…The importance of CD40/CD154 costimulatory pathway blockade in immunosuppression strategies is well‐documented. Efforts are currently focused on monoclonal…”
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Pathogen Stimulation History Impacts Donor‐Specific CD8+ T Cell Susceptibility to Costimulation/Integrin Blockade–Based Therapy by Badell, I. R., Kitchens, W. H., Wagener, M. E., Lukacher, A. E., Larsen, C. P., Ford, M. L.

“…Recent studies have shown that the quantity of donor‐reactive memory T cells is an important factor in determining the relative heterologous immunity barrier…”
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CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40‐Specific Antibody 3A8 by Badell, I. R., Russell, M. C., Cardona, K., Shaffer, V. O., Turner, A. P., Avila, J. G., Cano, J. A., Leopardi, F. V., Song, M., Strobert, E. A., Ford, M. L., Pearson, T. C., Kirk, A. D., Larsen, C. P.

“…Islet transplantation to treat type 1 diabetes has been limited in part by toxicities of current immunosuppression and recipient humoral sensitization…”
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Selective CD28 Blockade Results in Superior Inhibition of Donor‐Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4‐Ig by Badell, I. R., La Muraglia, G. M., Liu, D., Wagener, M. E., Ding, G., Ford, M. L.

“…Donor‐specific antibodies (DSAs) are a barrier to improved long‐term outcomes after kidney transplantation. Costimulation blockade with CTLA4‐Ig has shown…”
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Single Donor-Derived Pseudomonas aeruginosa Pseudoaneurysms in Two Kidney Transplant Recipients: A Case Report of Dichotomous Allograft Outcomes by Berger, M.F., Badell, I.R.

“…Infectious pseudoaneurysm (IPA) is a rare but devastating complication following renal transplantation that typically leads to graft loss and occasionally…”
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Domino Liver Transplantation in Maple Syrup Urine Disease: A Case Report and Review of the Literature by Badell, I.R, Hanish, S.I, Hughes, C.B, Hewitt, W.R, Chung, R.T, Spivey, J.R, Knechtle, S.J

“…Abstract Background Improved outcomes have expanded the indications for liver transplantation, thus aggravating the already limited supply of donor organs…”
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A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival by LOWE, M, BADELL, I. R, ADAMS, A. B, KIRK, A. D, LARSEN, C. P, REIMANN, K. A, THOMPSON, P, MARTIN, B, LEOPARDI, F, STROBERT, E, PRICE, A. A, ABDULKERIM, H. S, WANG, R, IWAKOSHI, N. N

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Tumor necrosis factor prevents alendronate‐induced osteoclast apoptosis in vivo by stimulating Bcl‐xL expression through Ets‐2 by Zhang, Q., Badell, I. R., Schwarz, E. M., Boulukos, K. E., Yao, Z., Boyce, B. F., Xing, L.

“…Objective To investigate why bisphosphonates are less effective at preventing focal bone loss in rheumatoid arthritis (RA) patients than in those with…”
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CTLA41g Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40-Specific Antibody 3A8 by BADELL, I. R, RUSSELL, M. C, FORD, M. L, PEARSON, T. C, KIRK, A. D, LARSEN, C. P, CARDONA, K, SHAFFER, V. O, TURNER, A. P, AVILA, J. G, CANO, J. A, LEOPARDI, F. V, SONG, M, STROBERT, E. A

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IMMUNOGENICITY OF ISLETS ISOLATED FROM THREE AND SEVEN DAY-OLD NEWBORN PIGS: 2677 by Arefanian, H., Mok, D. C., Ramji, Q., Badell, I. R., Thompson, P. W., Larsen, C., Gill, R. G., Korbutt, G. S., Rajotte, R. V., Rayat, G. R.

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Selective CD28 blockade results in superior inhibition of donor-specific T follicular helper cell and antibody responses relative to CTLA-4-Ig by Badell, IR, La Muraglia, GM, Liu, D, Wagener, ME, Ding, G, Ford, ML

“…Donor-specific antibodies (DSA) are a barrier to improved long-term outcomes following kidney transplantation. Costimulation blockade with CTLA-4-Ig has shown…”
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Anti-CD40-based Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates by Thompson, P, Cardona, K, Russell, M, Badell, IR, Shaffer, V, Korbutt, G, Cano, J, Song, M, Jiang, W, Strobert, E, Rajotte, R, Pearson, T, Kirk, AD, Larsen, CP

“…The widespread clinical implementation of alloislet transplantation as therapy for type 1 diabetes has been hindered by the lack of suitable islet donors…”
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CD40aSpecific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates by Thompson, P, Cardona, K, Russell, M, Badell, IR, Shaffer, V, Korbutt, G, Rayat, G R, Cano, J, Song, M, Jiang, W, Strobert, E, Rajotte, R, Pearson, T, Kirk, AD, Larsen, C P

“…The widespread clinical implementation of alloislet transplantation as therapy for type 1 diabetes has been hindered by the lack of suitable islet donors…”
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Non-Depleting Anti-CD40-Based Therapy Prolongs Allograft Survival in Nonhuman Primates by Badell, IR, Thompson, PW, Turner, AP, Russell, MC, Avila, JG, Cano, JA, Robertson, JM, Leopardi, FV, Strobert, EA, Iwakoshi, NN, Reimann, KA, Ford, ML, Kirk, AD, Larsen, CP

“…Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has…”
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