Search Results - "BACK, D. J"

Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells by Martin, P, Riley, R, Back, D J, Owen, A

“…Background and purpose: Certain nuclear receptors (NRs) such as the constitutive androstane receptor (CAR), pregnane X receptor (PXR) and farnesoid X receptor…”
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The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC by Liptrott, NJ, Penny, M, Bray, PG, Sathish, J, Khoo, SH, Back, DJ, Owen, A

“…Mandarin translation of Background and purpose:  The function of transporters in peripheral blood mononuclear cells (PBMC) has been characterized, but less is…”
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The intracellular pharmacology of antiretroviral protease inhibitors by Ford, J., Khoo, S. H., Back, D. J.

“…Therapeutic drug monitoring (TDM) of antiretroviral protease inhibitors (PIs) has been suggested to have the potential to both reduce toxicity and optimize…”
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Improved Oral Bioavailability of Lopinavir in Melt-Extruded Tablet Formulation Reduces Impact of Third Trimester on Lopinavir Plasma Concentrations by ELSE, L. J, DOUGLAS, M, DICKINSON, L, BACK, D. J, KHOO, S. H, TAYLOR, G. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Effect of Gene Variants on Levonorgestrel Pharmacokinetics When Combined With Antiretroviral Therapy Containing Efavirenz or Nevirapine by Neary, M, Lamorde, M, Olagunju, A, Darin, KM, Merry, C, Byakika‐Kibwika, P, Back, DJ, Siccardi, M, Owen, A, Scarsi, KK

“…Reduced levonorgestrel concentrations from the levonorgestrel contraceptive implant was previously seen when given concomitantly with efavirenz. We sought to…”
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Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir by Janneh, O, Hartkoorn, R C, Jones, E, Owen, A, Ward, S A, Davey, R, Back, D J, Khoo, S H

“…Background and purpose: Drug efflux tranporters (P‐glycoprotein (P‐gp), multidrug resistance‐associated protein (MRP)) limit the cellular uptake of human…”
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A Call for a Consortium for Optimal Management of Drug–Drug Interactions in Patient Care by Burger, DM, Smolders, EJ, Schapiro, J, Drenth, JPH, Back, DJ

“…During clinical development of medicines, manufacturers are obliged to assess the risk of drug–drug interactions (DDIs) with their new drug. There is no doubt…”
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Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir by Eagling, V. A., Back, D. J., Barry, M. G.

“…Aims To compare the inhibitory potential of the HIV protease inhibitors saquinavir, ritonavir and indinavir against CYP1A2, CYP2C9, CYP2E1 and CYP3A4 catalysed…”
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P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals by Meaden, E. R., Hoggard, P. G., Newton, P., Tjia, J. F., Aldam, D., Cornforth, D., Lloyd, J., Williams, I., Back, D. J., Khoo, S. H.

“…Objectives: Efflux transporters may play a role in lowering intracellular drug concentrations. As the HIV protease inhibitors are substrates for the efflux…”
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A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy by Sephton, V, Farquharson, R.G, Topping, J, Quenby, S.M, Cowan, C, Back, D.J, Toh, C.H

“…To assess the maternal response to low molecular weight heparin during pregnancy, by estimation of plasma anti-Xa activity, at three specified gestation points…”
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Therapeutic drug monitoring of atazanavir/ritonavir in pregnancy by Else, LJ, Jackson, V, Brennan, M, Back, DJ, Khoo, SH, Coulter‐Smith, S, Lambert, JS

“…Objectives Pregnant women experience physiological changes during pregnancy that can have a significant impact on antiretroviral pharmacokinetics. Ensuring…”
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Inhibition of the CYP3A4-mediated metabolism and p-glycoprotein-mediated transport of the HIV-I protease inhibitor saquinavir by grapefruit juice components by EAGLING, V. A, PROFIT, L, BACK, D. J

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The impact of pharmacogenetics on HIV therapy by Mahungu, T W, Johnson, M A, Owen, A, Back, D J

“…The use of highly active antiretroviral therapy in the treatment of HIV infection has resulted in significant reductions in mortality and morbidity worldwide…”
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Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy by Lambert, JS, Else, LJ, Jackson, V, Breiden, J, Gibbons, S, Dickinson, L, Back, DJ, Brennan, M, Connor, EO, Boyle, N, Fleming, C, Coulter‐Smith, S, Khoo, SH

“…Objectives The aim of the study was to determine total and unbound lopinavir (LPV) plasma concentrations in HIV‐infected pregnant women receiving…”
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Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes by Eagling, Victoria A., Tjia, John F., Back, David J.

“…Aims  Chemical inhibitors of cytochrome P450 (CYP) are a useful tool in defining the role of individual CYPs involved in drug metabolism. The aim of the…”
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A Compartmental Pharmacokinetic Evaluation of Long-Acting Rilpivirine in HIV-Negative Volunteers for Pre-Exposure Prophylaxis by Jackson, A G A, Else, L J, Mesquita, P M M, Egan, D, Back, D J, Karolia, Z, Ringner-Nackter, L, Higgs, C J, Herold, B C, Gazzard, B G, Boffito, M

“…Rilpivirine long‐acting (RPV‐LA) is a parenteral formulation enabling prolonged plasma exposure. We explored its multiple‐compartment pharmacokinetics (PK)…”
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Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors by PROFIT, L, EAGLING, V. A, BACK, D. J

“…To determine the effect of the protease inhibitors ritonavir, nelfinavir and indinavir on the P-glycoprotein (P-gp)-mediated transport of saquinavir in Caco-2…”
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Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro by HOGGARD, P. G, KEWN, S, BARRY, M. G, KHOO, S. H, BACK, D. J

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometry by Liptrott, N.J., Khoo, S.H., Back, D.J., Owen, A.

“…ABCC2 has a wide tissue distribution and can mediate the efflux of a number of therapeutic compounds from cells and contribute to potential treatment failure…”
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The Relationships of ABCB1 3435C>T and CYP2B6 516G>T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz by Mahungu, TW, Nair, D, Smith, CJ, Egan, D, Youle, M, Johnson, MA, Khoo, SH, Back, DJ, Owen, A

“…Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) are associated with a favorable increase in high‐density lipoprotein cholesterol (HDL‐c) level…”
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