Search Results - "BACHMANN, K. A."

Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise by Bachmann, K A

“…Strategies and standards for predicting the likelihood of pharmacokinetically significant inhibitory drug-drug interactions for drug development purposes which…”
Get more information

In situ ToF-SIMS monitoring of SOFC cathodes – A case study of La0.74Sr0.17Mn1.01O2.9 model electrodes by Rohnke, M., Schaepe, K., Bachmann, A.-K., Laenger, M., Janek, J.

“…[Display omitted] •Polarisation experiments of structurally well-defined SOFC thin film model electrodes.•Electrode surface composition changes reversibly with…”
Get full text

The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions by Bachmann, K A, Ghosh, R

“…With the dramatic change underway in the process of drug discovery and development it has become increasingly important to define, both qualitatively and…”
Get more information

Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans by Schwartz, Jules I., Chan, Chi‐Chung, Mukhopadhyay, Saurabh, McBride, Kathleen J., Jones, Terry M., Adcock, Sherilyn, Moritz, Carl, Hedges, Jerris, Grasing, Kenneth, Dobratz, David, Cohen, Robert A., Davidson, Michael H., Bachmann, Kenneth A., Gertz, Barry J.

“…Cyclooxygenase (COX) exists as constitutive (COX‐1) and inducible (COX‐2) isoforms. Nonsteroidal anti‐inflammatory drugs (NSAIDs) such as ibuprofen and…”
Get full text

Differential kinetics of phenytoin in elderly patients by BACHMANN, K. A, BELLOTO, R. J

“…The elderly have a relatively high risk of developing adverse drug reactions. Phenytoin continues to be a preferred drug for treating generalised tonic-clonic…”
Get full text

Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo by Bachmann, K A, Jauregui, L

“…1. Single sample clearance estimates (CL/F) of orally administered ethosuximide were obtained in four groups of healthy adult subjects. One group was treated…”
Get more information

Lack of Pharmacokinetic Interaction between Rofecoxib and Methotrexate in Rheumatoid Arthritis Patients by Schwartz, Jules I., Agrawal, Nancy G. B., Wong, Peggy H., Bachmann, Kenneth A., Porras, Arturo G., Miller, Jutta L., Ebel, David L., Sack, Marshall R., Holmes, Gregory B., Redfern, Jan S., Gertz, Barry J.

“…Rofecoxib is a highly selective and potent inhibitor of cyclooxgenase‐2 (COX‐2). Methotrexate is a disease‐modifying agent with a narrow therapeutic index…”
Get full text

Influence of Some Novel N-Substituted Azoles and Pyridines on Rat Hepatic CYP3A Activity by Slama, James T., Hancock, Julie L., Rho, Taikyun, Sambucetti, Lidia, Bachmann, Kenneth A.

“…A series of N-substituted heteroaromatic compounds structurally related to clotrimazole was synthesized, and the effects of these compounds on ethosuximide…”
Get full text

Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity by BACHMANN, K. A., SULLIVAN, T. J., JAUREGUI, L., REESE, J. H., MILLER, K., LEVINE, L.

“…The effects of omeprazole (40 mg orally per day) and nizatidine (300 mg orally per day) on the disposition of phenytoin (4.5 mg kg−1 p.o. single dose) were…”
Get full text

The influence of anesthetic agents on rat hepatic cytochromes P450 in vivo by Loch, J M, Potter, J, Bachmann, K A

“…The objective of this study was to identify which anesthetics when used acutely will affect cytochrome P450 (CYP) activity in male Sprague-Dawley rats in vivo…”
Get more information

Ethosuximide is Primarily Metabolized by CYP3A when Incubated with Isolated Rat Liver Microsomes by SARVER, J. G, BACHMANN, K. A, ZHU, D, KLIS, W. A

“…The cytochrome P450 (CYP) subfamily responsible for ethosuximide metabolism was investigated by HPLC assay of ethosuximide incubations with isolated rat liver…”
Get full text

The use of single-sample clearance estimates to probe hepatic drug metabolism in rats. IV. A model for possible application to phenotyping xenobiotic influences on human drug metabolism by Bachmann, K A

“…1. Conditions were examined under which estimates of drug clearance made from a single measurement of plasma concentration effectively represented multi-sample…”
Get more information

Predicting Inhibitory Drug-Drug Interactions and Evaluating Drug Interaction Reports Using Inhibition Constants by Bachmann, Kenneth A, Lewis, Jeffrey D

“…OBJECTIVE: To review the use of inhibitory constants (Ki) determined from in vitro experiments in the prediction of the significance of inhibitory drug—drug…”
Get full text

Multiple-dose pharmacokinetics of intravenously administered cefoperazone and sulbactam when given in combination to infected, seriously ill, elderly patients by SCHWARTZ, J. I, JAUREGUI, L. E, BACHMANN, K. A, MARTIN, M. E, REITBERG, D. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

The use of single sample clearance estimates to probe hepatic drug metabolism: handprinting the influence of phenobarbitone on human hepatic drug metabolism by Bachmann, K A, Nunlee, M, Martin, M, Jaregui, L

“…1. Single sample clearance estimates, CL, were calculated for seven drugs employed as probes of human hepatic drug-metabolizing enzymes. Clearance estimates…”
Get more information

The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances by Bachmann, K A, Madhira, M S, Rankin, G O

“…1. Four drugs--antipyrine, theophylline, quinidine, and ethosuximide--were used as probes of in vivo hepatic mixed function oxidase (MFO) activity. Functional…”
Get more information

Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats by Bachmann, K A, Sullivan, T J

“…A dose-response curve for the hypoprothrombinemic effect of brodifacoum 3-[-3(4'-bromobiphenyl-4-yl) 1,2,3,4-tetrahydronaphth-1-yl] -4-hydroxycoumarin, was…”
Get more information

Exercise training does not alter cytochrome P-450 content and microsomal metabolism by Michaud, T J, Bachmann, K A, Andres, F F, Flynn, M G, Sherman, G P, Rodriguez-Zayas, J

“…The purpose of this investigation was to determine whether increased endurance exercise capacity alters total hepatic cytochrome P-450 content and cytochrome…”
Get more information

Accuracy of two equations in determining normalized phenytoin concentrations by Mauro, L S, Mauro, V F, Bachmann, K A, Higgins, J T

“…The accuracy of two equations in normalizing total phenytoin concentrations in the presence of renal failure or hypoalbuminemia was evaluated in 11 renal…”
Get more information

An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats by Liu, D, Bachmann, K A

“…17 beta-Estradiol (E2) has long been known for protecting against coronary heart disease by lowering cholesterol levels in premenopausal women. A recent study…”
Get more information