Search Results - "BACHERT, Claus"

Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis by Bachert, Claus, MD, PhD, Zhang, Luo, MD, Gevaert, Phillippe, MD

“…Chronic rhinosinusitis (CRS) affects more than 10% of the population in the United States and Europe. Recent findings point to a considerable variation of…”
Get full text

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials by Gevaert, Philippe, Omachi, Theodore A., Corren, Jonathan, Mullol, Joaquim, Han, Joseph, Lee, Stella E., Kaufman, Derrick, Ligueros-Saylan, Monica, Howard, Monet, Zhu, Rui, Owen, Ryan, Wong, Kit, Islam, Lutaf, Bachert, Claus

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by IgE hyperproduction and eosinophilic inflammation. The anti-IgE antibody, omalizumab, has…”
Get full text

Pathogenesis of chronic rhinosinusitis: Inflammation by Van Crombruggen, Koen, PhD, Zhang, Nan, MD, Gevaert, Philippe, MD, Tomassen, Peter, MD, Bachert, Claus, MD, PhD

“…Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory diseases of the nasal and paranasal cavities either accompanied by polyp formation…”
Get full text

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology by Akdis, Cezmi A., MD, Bachert, Claus, MD, PhD, Cingi, Cemal, MD, Dykewicz, Mark S., MD, Hellings, Peter W., MD, Naclerio, Robert M., MD, Schleimer, Robert P., MD, Ledford, Dennis, MD

“…Chronic rhinosinusitis (CRS) is a complex disease consisting of several disease variants with different underlying pathophysiologies. Limited knowledge of the…”
Get full text

Real‐world benefits of allergen immunotherapy for birch pollen‐associated allergic rhinitis and asthma by Wahn, Ulrich, Bachert, Claus, Heinrich, Joachim, Richter, Hartmut, Zielen, Stefan

“…Background Real‐world evidence is sparse on the benefits of allergen immunotherapy [AIT; subcutaneous/sublingual immunotherapy (SCIT/SLIT)], the only…”
Get full text

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme by Krug, Norbert, Hohlfeld, Jens M, Kirsten, Anne-Marie, Kornmann, Oliver, Beeh, Kai M, Kappeler, Dominik, Korn, Stephanie, Ignatenko, Stanislav, Timmer, Wolfgang, Rogon, Cordelia, Zeitvogel, Jana, Zhang, Nan, Bille, Joachim, Homburg, Ursula, Turowska, Agnieszka, Bachert, Claus, Werfel, Thomas, Buhl, Roland, Renz, Jonas, Garn, Holger, Renz, Harald

“…GATA3 is thought to be a critical checkpoint in allergic diathesis. In this study, a synthetic DNAzyme that catalyzes the inactivation of GATA3 when…”
Get full text

Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania by Wang, Xiangdong, MD, PhD, Zhang, Nan, MD, PhD, Bo, MS, Mingyu, Holtappels, Gabriele, Zheng, Ming, MD, PhD, Lou, Hongfei, MD, PhD, Wang, Hong, BS, Zhang, Luo, MD, PhD, Bachert, Claus, MD, PhD

“…Background To date, no study has evaluated the diversity of TH cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different…”
Get full text

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus –derived serine protease–like protein D by Teufelberger, Andrea R., MSc, Nordengrün, Maria, MSc, Braun, Harald, PhD, Maes, Tania, PhD, De Grove, Katrien, MSc, Holtappels, Gabriele, BSc, O'Brien, Clara, BSc, Provoost, Sharen, PhD, Hammad, Hamida, PhD, Gonçalves, Amanda, MSc, Beyaert, Rudi, PhD, Declercq, Wim, PhD, Vandenabeele, Peter, PhD, Krysko, Dmitri V., PhD, Bröker, Barbara M., PhD, Bachert, Claus, PhD, Krysko, Olga, PhD

“…Background Chronic airway inflammatory diseases, such as chronic rhinosinusitis with nasal polyps and asthma, show increased nasal Staphylococcus aureus…”
Get full text

Type 2 inflammation in chronic rhinosinusitis without nasal polyps: Another relevant endotype by Delemarre, Tim, Holtappels, Gabriele, De Ruyck, Natalie, Zhang, Nan, Nauwynck, Hans, Bachert, Claus, Gevaert, Elien

“…Chronic rhinosinusitis without nasal polyps (CRSsNP) is mainly considered a type 1 mediated disease. The role and clinical significance of type 2 immune…”
Get full text

Endotypes of chronic rhinosinusitis: Impact on management by Cardell, Lars-Olaf, Stjärne, Pär, Jonstam, Karin, Bachert, Claus

“…Following the trend in asthma, endotypes for chronic rhinosinusitis with nasal polyps have been established, with type 2 immune reactions representing >80% of…”
Get full text

Evidence-based management of acute rhinosinusitis with herbal products by Bachert, Claus

“…Background The overuse of antibiotics for unjustified indications such as the management of acute uncomplicated rhinosinusitis has contributed to the emergence…”
Get full text

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis by Gevaert, Philippe, MD, PhD, Van Bruaene, Nicholas, MD, Cattaert, Tom, PhD, Van Steen, Kristel, PhD, Van Zele, Thibaut, MD, PhD, Acke, Frederic, MD, De Ruyck, Natalie, MSc, Blomme, Katrien, MSc, Sousa, Ana R., PhD, Marshall, Richard P., MD, PhD, Bachert, Claus, MD, PhD

“…Background Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic…”
Get full text

Phenotypes and Emerging Endotypes of Chronic Rhinosinusitis by Bachert, Claus, MD, PhD, Akdis, Cezmi A., MD

“…Chronic rhinosinusitis can be differentiated into several phenotypes based on clinical criteria; however, these phenotypes do not teach us much about the…”
Get full text

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers by Tomassen, Peter, MD, Vandeplas, Griet, MD, Van Zele, Thibaut, MD, PhD, Cardell, Lars-Olaf, MD, PhD, Arebro, Julia, MD, Olze, Heidi, MD, PhD, Förster-Ruhrmann, Ulrike, MD, Kowalski, Marek L., MD, PhD, Olszewska-Ziąber, Agnieszka, MD, Holtappels, Gabriele, De Ruyck, Natalie, Wang, Xiangdong, MD, PhD, Van Drunen, Cornelis, PhD, Mullol, Joaquim, MD, PhD, Hellings, Peter, MD, PhD, Hox, Valerie, MD, PhD, Toskala, Elina, MD, PhD, Scadding, Glenis, MD, Lund, Valerie, MD, Zhang, Luo, MD, PhD, Fokkens, Wytske, MD, PhD, Bachert, Claus, MD, PhD

“…Background Current phenotyping of chronic rhinosinusitis (CRS) into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal…”
Get full text

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment by Persson, Emma K, Verstraete, Kenneth, Heyndrickx, Ines, Gevaert, Elien, Aegerter, Helena, Percier, Jean-Michel, Deswarte, Kim, Verschueren, Koen H G, Dansercoer, Ann, Gras, Delphine, Chanez, Pascal, Bachert, Claus, Gonçalves, Amanda, Van Gorp, Hanne, De Haard, Hans, Blanchetot, Christophe, Saunders, Michael, Hammad, Hamida, Savvides, Savvas N, Lambrecht, Bart N

“…Although spontaneous protein crystallization is a rare event in vivo, Charcot-Leyden crystals (CLCs) consisting of galectin-10 (Gal10) protein are frequently…”
Get full text

Staphylococcal serine protease–like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus by Stentzel, Sebastian, PhD, Teufelberger, Andrea, Nordengrün, Maria, Kolata, Julia, PhD, Schmidt, Frank, PhD, van Crombruggen, Koen, PhD, Michalik, Stephan, PhD, Kumpfmüller, Jana, PhD, Tischer, Sebastian, Schweder, Thomas, PhD, Hecker, Michael, PhD, Engelmann, Susanne, PhD, Völker, Uwe, PhD, Krysko, Olga, PhD, Bachert, Claus, MD, PhD, Bröker, Barbara M., MD

“…Background A substantial subgroup of asthmatic patients have “nonallergic” or idiopathic asthma, which often takes a severe course and is difficult to treat…”
Get full text

Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China by Lou, Hongfei, Ma, Siyuan, Zhao, Yan, Cao, Feifei, He, Fei, Liu, Zhongyan, Bousquet, Jean, Wang, Chengshuo, Zhang, Luo, Bachert, Claus

“…Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is…”
Get full text

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation by Krysko, Dmitri V, Agostinis, Patrizia, Krysko, Olga, Garg, Abhishek D, Bachert, Claus, Lambrecht, Bart N, Vandenabeele, Peter

“…Cell death and injury often lead to release or exposure of intracellular molecules called damage-associated molecular patterns (DAMPs) or cell death-associated…”
Get full text

Novel porphyrazine-based photodynamic anti-cancer therapy induces immunogenic cell death by Turubanova, Victoria D., Mishchenko, Tatiana A., Balalaeva, Irina V., Efimova, Iuliia, Peskova, Nina N., Klapshina, Larisa G., Lermontova, Svetlana A., Bachert, Claus, Krysko, Olga, Vedunova, Maria V., Krysko, Dmitri V.

“…The immunogenicity of dying cancer cells determines the efficacy of anti-cancer therapy. Photodynamic therapy (PDT) can induce immunogenic cell death (ICD),…”
Get full text

Endoscopic Sinus Surgery for Type‐2 CRS wNP: An Endotype‐Based Retrospective Study by Alsharif, Saeed, Jonstam, Karin, van Zele, Thibaut, Gevaert, Philippe, Holtappels, Gabriele, Bachert, Claus

“…Objectives Nasal polyps are often characterized by type 2 inflammation and disease recurrence. We developed a new surgical technique, referred to as reboot…”
Get full text